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Full-Text Articles in Chemistry

Thermodynaimic Study Of Nucleic Acids Recognition By Aminoglycosides , Hongjuan Xi Dec 2007

Thermodynaimic Study Of Nucleic Acids Recognition By Aminoglycosides , Hongjuan Xi

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ABSTRACT


Since the origin of first aminoglycosides antibiotics, streptomycin, isolated by Selman Waksman about 60 years ago, a number of aminoglycosides antibiotics were discovered to treat different infections. Neomycin class aminoglycosides were found to originally target the A site 16S rRNA in the 30S subunit of the ribosome within the Gram-negative bacteria. In addition to its antibacterial effect, aminoglycosides were also found to binding to various other viral RNA structures such as TAR and RRE of HIV, Group I introns and hammerhead ribozyme, implying its potential to be used as antiviral reagent.

Furthermore, previous studies in our laboratory discovered a …


Development Of Fullerene Based Sturctures For Photovoltaic And Electronic Applications, Amit Palkar Dec 2007

Development Of Fullerene Based Sturctures For Photovoltaic And Electronic Applications, Amit Palkar

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Solar energy can be envisioned as a long term alternative to rapidly depleting fossil fuels. The energy from the sun can be harnessed by constructing donor-acceptor (D-A) type devices where the incident photon induces the transfer of an electron from the donor to the acceptor. If recombination is prevented, this electron can then be channeled through an external circuit, thus leading to the generation of photocurrent. Porphyrins, which are the naturally occurring pigments in photosynthesis, have been widely established as donors while fullerenes, such as C60 and C70 , due to their unique electron accepting properties, have been …


Lithium-Conducting Ionic Melt Electrolytes From Oligomeric Ethylene Glycols: Synthesis And Characterization, Boutros Hallac Dec 2007

Lithium-Conducting Ionic Melt Electrolytes From Oligomeric Ethylene Glycols: Synthesis And Characterization, Boutros Hallac

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Commercial lithium ion cells consist of electrolytes that undergo salt concentration polarization which is acute upon high discharge currents. This type of polarization occurs as a result of the mobility of more than one ionic species in the presence of an electric field. One way to overcome it is by employing a material that would allow the mobility of one ionic species. This thesis will describe the synthesis and characterization of several fluorosulfonimide and fluorosulfonate based ionic liquids/melts as electrolytes having lithium as the only mobile ion. These materials were prepared by the nucleophilic addition reaction of a deprotonated polyether …


The Glow Discharge - A Multifaceted Optical Emission Source: From Solids Analysis To Metalloproteins, Timothy Brewer May 2007

The Glow Discharge - A Multifaceted Optical Emission Source: From Solids Analysis To Metalloproteins, Timothy Brewer

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Glow discharges (GD) are well known for their application to direct solids elemental analysis of metals and alloys by optical emission spectroscopy (GD-OES). The most successful application of GD-OES has been the analysis of solid materials since the GD provides rapid, direct bulk and depth profiling analysis of solids, metals, powders, polymers, glasses and ceramics. However, solids analysis has typically suffered from the lack of true analytical blanks and the inability to study particulate solids in their native state. An approach for the analysis of solid powdered material entrapped in a sol-gel matrix by radio frequency glow discharge optical emission …


Analysis Of Nutraceuticals For Toxic Metals: Development And Validation Of Sample Preparation Method, Julia Cooper May 2007

Analysis Of Nutraceuticals For Toxic Metals: Development And Validation Of Sample Preparation Method, Julia Cooper

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With increasing numbers of health-conscious consumers purchasing nutraceutical supplements, total sales in the nutrition industry have soared to over $200 billion in 2006. It is important to assess the safety of these nutraceutical products, with specific regards to toxic metals, including arsenic, cadmium, lead, and mercury. Because species of these metals may be more toxic than others, they can have hazardous health effects if ingested in excess quantities. The work described in this thesis focuses on the development of a sample preparation method for nutraceutical products, specifically ethanolic tinctures and glycerin-based matrices, and analysis of these products by inductively coupled …