Chemistry Commons^™

Evaluation And In Vitro Studies Of Folate Peg Biotin And Other Peg Agents, Syed Zahid Hussain

All Capstone Projects

Folate is a member of vitamin B family and plays an essential role in cell survival by participating in the biosynthesis of nucleic and amino acids. Receptors folic acid are frequently over expressed on epithelial cancer cells. These receptors are believed to serve as a receptor-mediated transport system of folic acid into cancer cells and cells associated with inflammation. Interesting, most normal cells in the body have lower frequency of these receptors. Based on these attributes, folate based drug delivery, imaging systems, and diagnostic systems are in several stages of development worldwide.

In this current project, we have characterized the …

Method For Arsenic Detection In Mine Samples From The Upper Peninsula Of Michigan, Vinay Babu Yalamanchili

All Capstone Projects

Arsenic is the 20th abundant element in the earth crust. High concentrations of Arsenic is seen in mine operating countries which can affect public health and biological environment. This may reach to drinking water through ground or surface run-off water. Long term exposure to arsenic causes cancer of bladder, skin, and lungs. So detecting the amount of arsenic in soil and drinking has been an analytical challenge. Arsenic is found in variety of chemical forms in organic and inorganic compounds which results in chemical and physical interferences in the analysis. Graphite Furnace Atomic Absorption Spectroscopy (GFAAS) was used to measure …

Detection Of Folate Receptor From Fr+ Cells, Gopikrishna Pinnaka

All Capstone Projects

Targeted drug delivery is a newer and less explored arena that has potential scope in tumor targeting because the regular chemotherapy has lethal effects on the normal cells also. Our present Work was an attempt to specifically target receptors on cancerous cells, especially the Folate Receptor (FR). Folate is important for cells for DNA synthesis and the tissues that rapidly divide require folate, cancer cells are no exceptions for this. To cope with the increased demand for the folate the cancer cells express greater FR on the cell surface. This very fact was our basis for the construction of our …