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Full-Text Articles in Chemistry
Investigating Small Molecule Behavior In Living Bacterial Membranes With Second Harmonic Scattering, Marea J. Blake
Investigating Small Molecule Behavior In Living Bacterial Membranes With Second Harmonic Scattering, Marea J. Blake
Doctoral Dissertations
A molecule's entry into a cell is impeded primarily at the surface of Gram-positive bacteria. This interface serves as the boundary separating cellular contents from the external environment and is composed of a thick layer of peptidoglycan and a lipid bilayer equipped with protein and lipid species with various roles including that of small-molecule transport. As such, understanding these molecule-membrane interactions is imperative to examine in order to design novel drugs or adjuvants to combat the global antibiotic resistance predicament. Knowledge regarding passive diffusion and overall organization of small molecules in the lipid bilayer of living Gram-positive cells is limited …
High Resolution Mass Spectrometry As A Platform For The Analysis Of Polyoxometalates, Their Solution Phase Dynamics, And Their Biological Interactions., Daniel T. Favre
High Resolution Mass Spectrometry As A Platform For The Analysis Of Polyoxometalates, Their Solution Phase Dynamics, And Their Biological Interactions., Daniel T. Favre
Doctoral Dissertations
Polyoxometalates (POMs) are a class of inorganic molecule of increasing interest to the inorganic, bioinorganic and catalytic communities among many others. While their prevalence in research has increased, tools and methodologies for the analysis of their fundamental characteristics still need further development. Decavanadate (V10) specifically has been postulated to have several unique properties that have not been confirmed independently. Mass spectrometry (MS) and its ability to determine the composition of solution phase species by both mass and charge is uniquely well suited to the analysis of POMs. In this work we utilized high-resolution mass spectrometry to characterize V10 in aqueous …