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Full-Text Articles in Chemistry
Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material For 29si Magnetic Resonance Imaging, Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy S. Luu, Shivanand Pudakalakatti, Caitlin Mccowan, Yaewon Kim, Niki Zacharias Millward, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material For 29si Magnetic Resonance Imaging, Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy S. Luu, Shivanand Pudakalakatti, Caitlin Mccowan, Yaewon Kim, Niki Zacharias Millward, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Nicholas Whiting
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (~25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous …
Sure Poster 2018, Stephanie Armas, Cody Autrey, Enrique J. Blanco Martinez, Jared Church, Swadeshmukul Santra, Woo Hyoung Lee, Karin Y. Chumbimuni-Torres
Sure Poster 2018, Stephanie Armas, Cody Autrey, Enrique J. Blanco Martinez, Jared Church, Swadeshmukul Santra, Woo Hyoung Lee, Karin Y. Chumbimuni-Torres
Cody Autrey
Huanglongbing (HLB), more commonly known as citrus greening disease (CGD), is an insect-borne bacterial disease affecting citrus crops worldwide. CGD symptoms can be visually seen throughout the plant, displaying yellowing veins, asymmetrical chlorosis and blotchy leaves, leading to underdeveloped fruit with green colored and stained seeds. The mottling discoloration has been linked to zinc deficiency in the plant, thus monitoring varying zinc levels is our main concern. Well established tools for plant analysis such as Atomic Absorption Spectroscopy (AAS), X-Ray Fluorescence, among other methods are costly, non-portable and destructive. Here, we have developed and characterized two solid contact micro-ion-selective …