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Full-Text Articles in Astrophysics and Astronomy
Molecular Regulation Of Trophoblast Survival During Placentation And Pathologies Of Placental Insufficiency, Chandni V. Jain
Molecular Regulation Of Trophoblast Survival During Placentation And Pathologies Of Placental Insufficiency, Chandni V. Jain
Wayne State University Dissertations
HBEGF, is present in the uterus at the time of embryo implantation and protects first
trimester TB cells from apoptosis and promotes their invasion. The hypertensive disease, PE, in
which TB invasion of the uterine arteries is reduced and TB apoptosis is elevated, is
characterized by a reduction in HBEGF expression. In this study using a first trimester cell line
and villous explant culture key components involved in HBEGF survival signaling pathway were
identified. Specific MMP inhibitors established the requirement for MMP2 in HBEGF shedding
and upregulation. NGS identified a HIF regulated gene, HSPA6 (HSP70B’) and using specific
inhibitors it …