Astrophysics and Astronomy Commons^™

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Journal of the South Carolina Academy of Science

No abstract provided.

Using Dna Flow-Stretching Assay As A Tool To Validate The Tagging Of Dna-Binding Proteins For Single-Molecule Experiments, Miranda Molina, Lindsey E. Way, Zhongqing Ren, Qin Liao, Bianca Guerra, Brandon Shields, Xindan Wang, Hyeongjun Kim

Physics and Astronomy Faculty Publications and Presentations

Highlights

• KCK tag can alter protein properties both quantitatively and qualitatively

• Electrostatic interactions between the KCK tag and DNA contribute to the artifacts

• Adding a short peptide tag to ParB protein does not lead to its in vivo changes

• Single-molecule DNA flow-stretching assay can detect protein property changes

Motivation

Single-molecule fluorescence microscopy has been extensively used in modern biology to define the molecular action of proteins. Appending short peptide tags is a common strategy to enhance fluorescence labeling. Here, we evaluate the impact of a commonly used tag, the lysine-cysteine-lysine (KCK) tag, on protein behavior in single-molecule DNA flow-stretching assay, …

Du Undergraduate Showcase: Research, Scholarship, And Creative Works, Caitlyn Aldersea, Justin Bravo, Sam Allen, Anna Block, Connor Block, Emma Buechler, Maria De Los Angeles Bustillos, Arianna Carlson, William Christensen, Olivia Kachulis, Noah Craver, Kate Dillon, Muskan Fatima, Angel Fernandes, Emma Finch, Colleen Cassidy, Amy Fishman, Andrea Francis, Stacia Fritz, Simran Gill, Emma Gries, Rylie Hansen, Shannon Powers, Jacqueline Martinez, Zachary Harker, Ashley Hasty, Mykaela Tanino-Springsteen, Kathleen Hopps, Adelaide Kerenick, Colin Kleckner, Ci Koehring, Elijah Kruger, Braden Krumholz, Maddie Leake, Lyneé Alves, Seraphina Loukas, Yatzari Lozano Vazquez, Haley Maki, Emily Martinez, Sierra Mckinney, Mykaela Tanino-Springsteen, Audrey Mitchell, Kipling Newman, Audrey Ng, Megan Lucyshyn, Andrew Nguyen, Stevie Ostman, Casandra Pearson, Alexandra Penney, Julia Gielczynski, Tyler Ball, Anna Rini, Christina Rorres, Simon Ruland, Helayna Schafer, Emma Sellers, Sarah Schuller, Claire Shaver, Kevin Summers, Isabella Shaw, Madison Sinar, Claudia Pena, Apshara Siwakoti, Carter Sorensen, Madi Sousa, Anna Sparling, Alexandra Revier, Brandon Thierry, Dylan Tyree, Maggie Williams, Lauren Wols

DU Undergraduate Research Journal Archive

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Optimizing Course Offerings In A Science Department, Yu Kay Law

Academic Chairpersons Conference Proceedings

We will discuss how enrollment data and faculty/advisor input can be used to maximize schedule efficiency in course offerings and providing for student success. We will also discuss how best to monitor and rearrange course schedules in light of actual enrollment.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

2022 Scas Annual Meeting Program And Bulletin

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

The Next Small Step, Samiya Henry

Undergraduate Research and Scholarship Symposium

As of right now, NASA and other space programs are estimating that by 2026, there will be people living in Space. Whether it be the Moon or Mars, one cannot have a functional society without a proper source of laws, especially since no one country has ownership over space. "One Small Step" will produce this source of laws, called the “Space Bill of Rights,” that will outline important matters like the trade of resources, medical care, government officials, and will ensure the preservation of our physical and figurative footsteps in space. This Space Bill of Rights is made up of …

Intramolecular Friedel-Crafts Addition Of Indoles To Tertiary Allylic Alcohols, Bryan H. Wakefield, Romie Barnes, Traeannah Brown, Ashley M. Jones, Victoria A. Knotts, Christina Martinetti

Journal of the South Carolina Academy of Science

An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles.

Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang

Physics and Astronomy Faculty Publications and Presentations

The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected bisbenzimide compound RO-90-7501 for further study. We generated analogues of RO-90-7501 and found that one compound, MRT00210423, had increased anti-HCMV activity compared to RO-90-7501. Using a combination of compound analogues, microscopy and biochemical assays we found RO-90-7501 and MRT00210423 interacted with DNA. In single molecule microscopy experiments we found RO-90-7501, but not MRT00210423, was able to compact DNA, …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

2021 Scas Annual Meeting Program And Bulletin

Journal of the South Carolina Academy of Science

No abstract provided.

Grappling With Covid-19 By Imposing And Lifting Nonpharmaceutical Interventions In Sri Lanka: A Modeling Perspective, Mahesh Jayaweera, Chamath Dannongoda, Dilum Dilshan, Janith Dissanayake, Hasini Perera, Jagath Manatunge, Buddhika Gunawardana

Physics and Astronomy Faculty Publications and Presentations

The imposition and lifting of non-pharmaceutical interventions (NPIs) to avert the COVID19 pandemic have gained popularity worldwide and will continue to be enforced until herd immunity is achieved. We developed a linear regression model to ascertain the nexus between the time-varying reproduction number averaged over a time window of six days (Rts) and seven NPIs: contact tracing, quarantine efforts, social distancing and health checks, hand hygiene, wearing of facemasks, lockdown and isolation, and health-related supports. Our analysis suggests that the second wave that emerged in Sri Lanka in early October 2020 continued despite numerous NPIs. The model indicates that the …

Active Magnetic Radiation Shielding For Long-Duration Human Spaceflight, Kristine Ferrone

Dissertations & Theses (Open Access)

Exploration of interplanetary space presents dramatic hazards to human survival.

Space radiation hazards outside the protection of the Earth’s magnetosphere can

produce both acute and chronic health risks and thus become limiting factors for

NASA’s planned mission to Mars by the 2030s. Radiation exposure on a Mars mission

is delivered primarily by high energy ions from galactic cosmic rays and moderate

energy protons from solar particle events. The chronic radiation dose due to galactic

cosmic rays on a typical Mars mission is on the order of 1 Sv, and additional acute

radiation dose from solar flares can reach over 4 …

Covid-19_Umaine News_Emera Astronomy Center Supports Covid-19 Research Efforts, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of Maine News release regarding the Emera Astronomy Center at the University of Maine contributing to global scientific research efforts to fight COVID-19.

Elaia 2019, Stephen Case

ELAIA

DIRECTOR'S NOTE in Volume 2

Each fall, the Honors Program at Olivet Nazarene University admits a small number of academically gifted students into its freshman class. From the moment they set foot on our campus, these women and men join a community of scholars, and together they read, reflect upon, and discuss the most important ideas of the past and present—all within a Christian fellowship. The first two years of the program involve a series of Honors courses, taught by a team of faculty and modeled on the historic “old-time college,” where small class relationships, interdisciplinary discussion, and debate prevailed. …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Identified Flying Objects: A Multidisciplinary Scientific Approach To The Ufo Phenomenon, Dr. Michael P. Masters

Interdisciplinary Arts and Sciences Books

Identified Flying Objects cautiously examines the premise that ‘UFOs’ & ‘Aliens’ are simply our distant human descendants, returning from the future to study their own hominin evolutionary past. This text challenges readers to consider new possibilities while cultivating conversations about our ever-evolving understanding of time & time travel.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Non-Locality, Precognition & Spirit From The Physics Point Of View, Florentin Smarandache, Victor Christianto

Branch Mathematics and Statistics Faculty and Staff Publications

There are various supernatural phenomena which can hardly be explained by the existing mainstream science, for instance non-local interactions (e.g. ESP) and also precognitive interdictions. And there are other problems such as how to include the Spirit in the framework of physics. For example, it has been known for long time that intuition plays significant role in many professions and human life, including entrepreneurship, government, and also in detective or law enforcement activities. Despite these examples, such a precognitive interdiction is hardly accepted in mainstream science. In this paper, we discuss non-local interactions and advanced solutions of Maxwell equations, and …

Astromimetics: The Dawn Of A New Era For (Bio)Materials Science?, Vuk Uskoković, Victoria M. Wu

Pharmacy Faculty Articles and Research

Composite, multifunctional fine particles are likely to be at the frontier of materials science in the foreseeable future. Here we present a submicron composite particle that mimics the stratified structure of the Earth by having a zero-valent iron core, a silicate/silicide mantle, and a thin carbonaceous crust resembling the biosphere and its biotic deposits. Particles were formulated in a stable colloidal form and made to interact with various types of healthy and cancer cells in vitro. A selective anticancer activity was observed, promising from the point of view of the intended use of the particles for tumor targeting across the …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Proposed Method For Measuring The Let Of Radiotherapeutic Particle Beams, Stephen D. Bello

Physics & Astronomy ETDs

The Bragg peak geometry of the depth dose distributions for hadrons allows for precise and effective dose delivery to tumors while sparing neighboring healthy tissue. Further, compared against other forms of radiotherapeutic treatments, such as electron beam therapy (EBT) or photons (x and \(\gamma\)-rays), hadrons create denser ionization events along the particle track, which induces irreparable damage to DNA, and thus are more effective at inactivating cancerous cells. The measurement of radiation's ability to inactivate cellular reproduction is the relative biological effectiveness (RBE). A quality related to the RBE that is a measurable physical property is the linear energy transfer …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Better Together

DePaul Magazine

Faculty have taken full advantage of the university's innovative intercollegiate grant program, and the resulting research is as interesting and diverse as the collaborators themselves. What is resulting is research on "Patient and Primary Care Provider Perspectives on Recreational and Therapeutic Cannabis Use Within a Changing Socioculltural and Political Context;" a new minor in climate change science and policy; a new class, Communication, Coding and Entrepreneurship; brain inflammation research; and the project "Cosmology Meets Continental Philosophy: Natural Laws and Why There Is Something Rather Than Nothing"

Hpcnmf: A High-Performance Toolbox For Non-Negative Matrix Factorization, Karthik Devarajan, Guoli Wang

COBRA Preprint Series

Non-negative matrix factorization (NMF) is a widely used machine learning algorithm for dimension reduction of large-scale data. It has found successful applications in a variety of fields such as computational biology, neuroscience, natural language processing, information retrieval, image processing and speech recognition. In bioinformatics, for example, it has been used to extract patterns and profiles from genomic and text-mining data as well as in protein sequence and structure analysis. While the scientific performance of NMF is very promising in dealing with high dimensional data sets and complex data structures, its computational cost is high and sometimes could be critical for …

Depth-Resolved Multispectral Sub-Surface Imaging Using Multifunctional Upconversion Phosphors With Paramagnetic Properties, Zaven Ovanesyan, L. Christopher Mimun, Gangadharan Ajith Kumar, Brian G. Yust, Chamath Dannongoda, Karen S. Martirosyan, Dhiraj K. Sardar

Physics and Astronomy Faculty Publications and Presentations

Molecular imaging is very promising technique used for surgical guidance, which requires advancements related to properties of imaging agents and subsequent data retrieval methods from measured multispectral images. In this article, an upconversion material is introduced for subsurface near-infrared imaging and for the depth recovery of the material embedded below the biological tissue. The results confirm significant correlation between the analytical depth estimate of the material under the tissue and the measured ratio of emitted light from the material at two different wavelengths. Experiments with biological tissue samples demonstrate depth resolved imaging using the rare earth doped multifunctional phosphors. In …