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Full-Text Articles in Other Applied Mathematics
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …
Construction Algorithms For Expander Graphs, Vlad S. Burca
Construction Algorithms For Expander Graphs, Vlad S. Burca
Senior Theses and Projects
Graphs are mathematical objects that are comprised of nodes and edges that connect them. In computer science they are used to model concepts that exhibit network behaviors, such as social networks, communication paths or computer networks. In practice, it is desired that these graphs retain two main properties: sparseness and high connectivity. This is equivalent to having relatively short distances between two nodes but with an overall small number of edges. These graphs are called expander graphs and the main motivation behind studying them is the efficient network structure that they can produce due to their properties. We are specifically …