Other Applied Mathematics Commons^™

Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost

All Dissertations

In confocal single-molecule FRET experiments, the joint distribution of FRET efficiency and donor lifetime distribution can reveal underlying molecular conformational dynamics via deviation from their theoretical Forster relationship. This shift is referred to as a dynamic shift. In this study, we investigate the influence of the free energy landscape in protein conformational dynamics on the dynamic shift by simulation of the associated continuum reaction coordinate Langevin dynamics, yielding a deeper understanding of the dynamic and structural information in the joint FRET efficiency and donor lifetime distribution. We develop novel Langevin models for the dye linker dynamics, including rotational dynamics, based …

Rigid Body Constrained Motion Optimization And Control On Lie Groups And Their Tangent Bundles, Brennan S. Mccann

Doctoral Dissertations and Master's Theses

Rigid body motion requires formulations where rotational and translational motion are accounted for appropriately. Two Lie groups, the special orthogonal group SO(3) and the space of quaternions H, are commonly used to represent attitude. When considering rigid body pose, that is spacecraft position and attitude, the special Euclidean group SE(3) and the space of dual quaternions DH are frequently utilized. All these groups are Lie groups and Riemannian manifolds, and these identifications have profound implications for dynamics and controls. The trajectory optimization and optimal control problem on Riemannian manifolds presents significant opportunities for theoretical development. Riemannian optimization is an attractive …

Stability Of Cauchy's Equation On Δ+., Holden Wells

Electronic Theses and Dissertations

The most famous functional equation f(x+y)=f(x)+f(y) known as Cauchy's equation due to its appearance in the seminal analysis text Cours d'Analyse (Cauchy 1821), was used to understand fundamental aspects of the real numbers and the importance of regularity assumptions in mathematical analysis. Since then, the equation has been abstracted and examined in many contexts. One such examination, introduced by Stanislaw Ulam and furthered by Donald Hyers, was that of stability. Hyers demonstrated that Cauchy's equation exhibited stability over Banach Spaces in the following sense: functions that approximately satisfy Cauchy's equation are approximated with the same level of error by functions …

Data And Algorithmic Modeling Approaches To Count Data, Andraya Hack

Honors College Theses

Various techniques are used to create predictions based on count data. This type of data takes the form of a non-negative integers such as the number of claims an insurance policy holder may make. These predictions can allow people to prepare for likely outcomes. Thus, it is important to know how accurate the predictions are. Traditional statistical approaches for predicting count data include Poisson regression as well as negative binomial regression. Both methods also have a zero-inflated version that can be used when the data has an overabundance of zeros. Another procedure is to use computer algorithms, also known as …

Vertical Take-Off And Landing Control Via Dual-Quaternions And Sliding Mode, Joshua Sonderegger

Doctoral Dissertations and Master's Theses

The landing and reusability of space vehicles is one of the driving forces into renewed interest in space utilization. For missions to planetary surfaces, this soft landing has been most commonly accomplished with parachutes. However, in spite of their simplicity, they are susceptible to parachute drift. This parachute drift makes it very difficult to predict where the vehicle will land, especially in a dense and windy atmosphere such as Earth. Instead, recent focus has been put into developing a powered landing through gimbaled thrust. This gimbaled thrust output is dependent on robust path planning and controls algorithms. Being able to …

Applications With Discrete And Continuous Models: Harvesting And Contact Tracing, Danielle L. Burton

Doctoral Dissertations

Harvest plays an important role in management decisions, from fisheries to pest control. Discrete models enable us to explore the importance of timing of management decisions including the order of events of particular actions. We derive novel mechanistic models featuring explicit within season harvest timing and level. Our models feature explicit discrete density independent birth pulses, continuous density dependent mortality, and density independent harvest level at a within season harvest time. We explore optimization of within-season harvest level and timing through optimal control of these population models. With a fixed harvest level, harvest timing is taken as the control. Then …

Numerical Simulations For Optimal Control Of A Cancer Cell Model With Delay, Jessica S. Lugo

Murray State Theses and Dissertations

Mathematical models are often created to analyze the complicated behavior of many physical systems. One such system is that of the interaction between cancer cells, the immune system, and various treatments such as chemotherapy, radiation, and immunotherapy. Using models that depict these relationships gives researchers insight on the dynamics of this complicated system and possibly ideas for improved treatment schedules.

The model presented here gives the relationship of cancer cells in development phases with immune cells and cycle-specific chemotherapy treatment. This model includes a constant delay term in the mitotic phase. Optimal control theory is used to minimize the cost …

Progenitors Involving Simple Groups, Nicholas R. Andujo

Electronic Theses, Projects, and Dissertations

I will be going over writing representations of both permutation and monomial progenitors, which include 2^{*4} : D_4, 2^(*7) :L_2 (7) as permutation progenitors, and monomial progenitors 7^(*2) :_m S_3 \times 2, 11^{*2} :_m (5:2)^{*}5, 11^{*3} :_m (25:3), 11^{*4} :_m (4 : 5)^{*}5. Also, the images of these different progenitors at both lower and higher fields and orders. \\ We will also do the double coset enumeration of S5 over D6, S6 over 5 : 4, A_5 x A_5 over (5:2)^{*}5, and go on to also do the double coset enumeration over maximal subgroups for larger constructions. We will also …

Population Modeling For Resource Allocation And Antimicrobial Stewardship, Jason Bintz

Doctoral Dissertations

This dissertation contains two types of population models with applications in conservation biology and epidemiology. In particular, it considers models for resource allocation and antimicrobial stewardship.

In a population model with a parabolic differential equation and density dependent growth, we study the problem of allocating resources to maximize the net benefit in the conservation of a single species while the cost of the resource allocation is minimized. The net benefit is measured in terms of maximizing population abundance and the goal of maximizing abundance is divided between the goal of maximizing the overall abundance across space and time and the …

Analysis Of Solvability And Applications Of Stochastic Optimal Control Problems Through Systems Of Forward-Backward Stochastic Differential Equations., Kirill Yevgenyevich Yakovlev

Doctoral Dissertations

A stochastic metapopulation model is investigated. The model is motivated by a deterministic model previously presented to model the black bear population of the Great Smoky Mountains in east Tennessee. The new model involves randomness and the associated methods and results differ greatly from the deterministic analogue. A stochastic differential equation is studied and the associated results are stated and proved. Connections between a parabolic partial differential equation and a system of forward-backward stochastic differential equations is analyzed.

A "four-step" numerical scheme and a Markovian type iterative numerical scheme are implemented. Algorithms and programs in the programming languages C and …