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Full-Text Articles in Applied Mathematics
Hepatitis B And D: A Forecast On Actions Needed To Reduce Incidence And Achieve Elimination, Scott Greenhalgh, Andrew Klug
Hepatitis B And D: A Forecast On Actions Needed To Reduce Incidence And Achieve Elimination, Scott Greenhalgh, Andrew Klug
Spora: A Journal of Biomathematics
Viral hepatitis negatively affects the health of millions, with the worst health outcomes associated with the hepatitis D virus (HDV). Fortunately, HDV is rare and requires prior infection with the hepatitis B virus (HBV) before it can establish infection and transmit. Here, we develop a mathematical model of HBV and HDV transmission in Sub-Saharan Africa to investigate the effects of hepatitis B vaccination on both HBV and HDV. Our findings illustrate a hepatitis B vaccination rate above 0.006 year-1 reduces hepatitis D by over 90%, and a vaccination rate above 0.0221 year-1 reduces hepatitis B by over 90%, …
Spontaneous Calcium Release In Cardiac Myocytes: Store Overload And Electrical Dynamics, Amanda M. Alexander, Erin K. Denardo, Eric Frazier Iii, Michael Mccauley, Nicholas Rojina, Zana Coulibaly, Bradford E. Peercy, Leighton T. Izu
Spontaneous Calcium Release In Cardiac Myocytes: Store Overload And Electrical Dynamics, Amanda M. Alexander, Erin K. Denardo, Eric Frazier Iii, Michael Mccauley, Nicholas Rojina, Zana Coulibaly, Bradford E. Peercy, Leighton T. Izu
Spora: A Journal of Biomathematics
Heart disease is the leading cause of mortality in the United States. One cause of heart arrhythmia is calcium (Ca2+) mishandling in cardiac muscle cells. We adapt Izu's et al. mathematical reaction-diffusion model of calcium in cardiac muscle cells, or cardiomyocytes implemented by Gobbert, and analyzed in Coulibaly et al. to include calcium being released from the sarcoplasmic reticulum (SR), the effects of buffers in the SR, particularly calsequestrin, and the effects of Ca2+ influx due to voltage across the cell membrane. Based on simulations of the model implemented in parallel using MPI, our findings aligned with …