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Full-Text Articles in Applied Mathematics
Hemodynamic Characteristics Of Stable And Unstable Vertebrobasilar Dolichoectatic And Fusiform Aneurysms, Waleed Brinjikji, Bong Jae Chung, Ding Yong-Hong, John T. Wald, Fernando Mut, Ramanathan Kadirvel, David F. Kallmes, Aymeric Rouchaud, Giuseppe Lanzino, Juan R. Cebral
Hemodynamic Characteristics Of Stable And Unstable Vertebrobasilar Dolichoectatic And Fusiform Aneurysms, Waleed Brinjikji, Bong Jae Chung, Ding Yong-Hong, John T. Wald, Fernando Mut, Ramanathan Kadirvel, David F. Kallmes, Aymeric Rouchaud, Giuseppe Lanzino, Juan R. Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. …
Regional Mapping Of Flow And Wall Characteristics Of Intracranial Aneurysms, Juan R. Cebral, Xinjie Duan, Piyusha S. Gade, Bong Jae Chung, Fernando Mut, Khaled Aziz, Anne M. Robertson
Regional Mapping Of Flow And Wall Characteristics Of Intracranial Aneurysms, Juan R. Cebral, Xinjie Duan, Piyusha S. Gade, Bong Jae Chung, Fernando Mut, Khaled Aziz, Anne M. Robertson
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
The evolution of intracranial aneurysms (IAs) is thought to be driven by progressive wall degradation in response to abnormal hemodynamics. Previous studies focused on the relationship between global hemodynamics and wall properties. However, hemodynamics, wall structure and mechanical properties of cerebral aneurysms can be non-uniform across the aneurysm wall. Therefore, the aim of this work is to introduce a methodology for mapping local hemodynamics to local wall structure in resected aneurysm specimens. This methodology combines image-based computational fluid dynamics, tissue resection, micro-CT imaging of resected specimens mounted on 3D-printed aneurysm models, alignment to 3D vascular models, multi-photon microscopy of the …