Applied Mathematics Commons^™

Meta-Analysis Of Mesenchymal Stem Cell Gene Expression Data From Obese And Non-Obese Patients, Dakota William Shields

Masters Theses

"The prevalence of gene expression microarray datasets in public repositories gives opportunity to analyze biologically interesting datasets without running the laboratory aspect in house. Such experimentation is expensive in terms of finances, time, and expertise, which often results in low numbers of replicates. Meta-analysis techniques attempt to overcome issues due to few biological or technical replicates by combining separate experiments together to increase statistical power. Proper statistical considerations help to offset issues like simultaneous testing of thousands of genes, unintended hybridization, and other noises.

Microarrays contain light intensities from tens of thousands of hybridized probes giving a measure of gene …

Continuous And Discrete Models For Optimal Harvesting In Fisheries, Nagham Abbas Al Qubbanchee

Masters Theses

"This work focuses on the logistic growth model, where the Gordon-Schaefer model is considered in continuous time. We view the Gordon-Schaefer model as a bioeconomic equation involved in the fishing business, considering biological rates, carrying capacity, and total marginal costs and revenues. In [25], the authors illustrate the analytical solution of the Schaefer model using the integration by parts method and two theorems. The theorems have many assumptions with many different strategies. Due to the nature of the problem, the optimal control system involves many equations and functions, such as the second root of the equation. We concentrate on Theorem …

The Application Of Machine Learning Models In The Concussion Diagnosis Process, Sujit Subhash

Masters Theses

“Concussions represent a growing health concern and are challenging to diagnose and manage. Roughly four million concussions are diagnosed every year in the United States. Although research into the application of advanced metrics such as neuroimages and blood biomarkers has shown promise, they are yet to be implemented at a clinical level due to cost and reliability concerns. Therefore, concussion diagnosis is still reliant on clinical evaluations of symptoms, balance, and neurocognitive status and function. The lack of a universal threshold on these assessments makes the diagnosis process entirely reliant on a physician’s interpretation of these assessment scores. This study …

Family-Based Association Studies Of Autism In Boys Via Facial-Feature Clusters, Luke Andrew Settles

Masters Theses

"Autism spectrum disorder (ASD) refers to a set of developmental disorders with varied attributes. Due to its substantial heterogeneity in terms of behavioral and clinical phenotypes, it is challenging to discern the genetic biomarkers behind ASD, even though the disease is known to be genetic in nature. This serves as a motivation to detect relationships between single nucleotide polymorphisms (SNPs) and a causal autism disease susceptibility locus (DSL) within more homogeneous subgroups. Recently, clinically meaningful subclassifications of ASD have been discovered utilizing facial features of prepubescent boys. Therefore, through the employment of data from 44 prepubertal Caucasian boys with ASD …

Application Of Loglinear Models To Claims Triangle Runoff Data, Netanya Lee Martin

Masters Theses

"In this thesis, we presented in detail different aspects of Verrall's chain ladder method and their advantages and disadvantages. Insurance companies must ensure there are enough reserves to cover future claims. To that end, it is useful to estimate mean expected losses. The chain ladder technique under a general linear model is the most widely used method for such estimation in property and casualty insurance. Verrall's chain ladder technique develops estimators for loss development ratios, mean expected ultimate claims, Bayesian premiums, and Bühlmann credibility premiums. The chain ladder technique can be used to estimate loss development in cases where data …

Statistical Mechanics And Schramm-Loewner Evolution With Applications To Crack Propagation Processes, Christopher Borut Mesic

Masters Theses

Schramm-Loewner Evolution (SLE) has both mathematical and physical roots that extend as far back as the early 20th century. We present the progression of these humble roots from the Ideal Gas Law, all the way to the renormalization group and conformal field theory, to better understand the impact SLE has had on modern statistical mechanics. We then explore the potential application of the percolation exploration process to crack propagation processes, illustrating the interplay between mathematics and physics.