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Full-Text Articles in Applied Mathematics
Comparison Of Fecal Microbiota In Children With Autism Spectrum Disorders And Neurotypical Siblings In The Simons Simplex Collection, Joshua S. Son, Ling J. Zheng, Leahana M. Rowehl, Ellen Li, Xinyu Tian, Yuanhao Zhang, Wei Zhu, Leighann Litcher-Kelly, Kenneth D. Gadow, Grace Gathungu, Charles E. Robertson, Diana Ir, Daniel N. Frank
Comparison Of Fecal Microbiota In Children With Autism Spectrum Disorders And Neurotypical Siblings In The Simons Simplex Collection, Joshua S. Son, Ling J. Zheng, Leahana M. Rowehl, Ellen Li, Xinyu Tian, Yuanhao Zhang, Wei Zhu, Leighann Litcher-Kelly, Kenneth D. Gadow, Grace Gathungu, Charles E. Robertson, Diana Ir, Daniel N. Frank
Department of Applied Mathematics & Statistics Faculty Publications
In order to assess potential associations between autism spectrum disorder (ASD) phenotype, functional GI disorders and fecal microbiota, we recruited simplex families, which had only a single ASD proband and neurotypical (NT) siblings, through the Simons Simplex Community at the Interactive Autism Network (SSC@IAN). Fecal samples and metadata related to functional GI disorders and diet were collected from ASD probands and NT siblings of ASD probands (age 7–14). Functional gastrointestinal disorders (FGID) were assessed using the parent-completed ROME III questionnaire for pediatric FGIDs, and problem behaviors were assessed using the Child Behavior Check List (CBCL). Targeted quantitative polymerase chain reaction …