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Applied Mathematics Commons

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Full-Text Articles in Applied Mathematics

Modeling Control Of Hiv Infection Through Structured Treatment Interruptions With Recommendations For Experimental Protocol, Shannon Kubiak, Heather Lehr, Rachel Levy, Todd Moeller, Albert Parker, Edward Swim Nov 2001

Modeling Control Of Hiv Infection Through Structured Treatment Interruptions With Recommendations For Experimental Protocol, Shannon Kubiak, Heather Lehr, Rachel Levy, Todd Moeller, Albert Parker, Edward Swim

All HMC Faculty Publications and Research

Highly Active Anti-Retroviral Therapy (HAART) of HIV infection has significantly reduced morbidity and mortality in developed countries. However, since these treatments can cause side effects and require strict adherence to treatment protocol, questions about whether or not treatment can be interrupted or discontinued with control of infection maintained by the host immune system remain to be answered. We present sensitivity analysis of a compartmental model for HIV infection that allows for treatment interruptions, including the sensitivity of the compartments themselves to our parameters as well as the sensitivity of the cost function used in parameter estimation. Recommendations are made about …


Methods For Volume Measurement In 3d Images, Kevin J. Black Jan 2001

Methods For Volume Measurement In 3d Images, Kevin J. Black

Kevin J. Black, MD

This letter attempted to politely direct readers of a later, remarkably similar publication to my original publication. The full text as submitted is attached as a PDF file.
The poster cited in the attached letter is available here.
ADDENDUM: Approximately the same work as the article discussed in this letter was also published as: Rajapakse JC: Random-grid stereologic volumetry of MR head scans. J Magn Reson Imaging 12:833-841, 2000. I wrote a similar, unpublished letter to the editor of JMRI in 12/2000.