Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Simulation (2)
- Asthma (1)
- Cancer (1)
- Clonal evolution (1)
- Computational biology (1)
-
- Copy number aberrations (1)
- Desensitisation (1)
- Drug partial agonism (1)
- FLASH therapy (1)
- Finite element analysis (1)
- GPCRs (1)
- Image variability (1)
- Information theory (1)
- Mathematical modelling (1)
- Microradiotherapy (1)
- Monte Carlo particle transport (1)
- Multinomial distribution (1)
- Mutual information (1)
- Optimization (1)
- Orthovoltage (1)
- Pharmacology (1)
- Ploidy (1)
- Preclinical research (1)
- Quantitative MRI (1)
- Quantum estimation (1)
- Quantum model (1)
- Salmeterol (1)
- Single-cell sequencing (1)
- Small animal radiotherapy (1)
- Species capture problem (1)
Articles 1 - 4 of 4
Full-Text Articles in Applied Mathematics
Proof-Of-Concept For Converging Beam Small Animal Irradiator, Benjamin Insley
Proof-Of-Concept For Converging Beam Small Animal Irradiator, Benjamin Insley
Dissertations & Theses (Open Access)
The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL., and
several analytical radiation transport methods were employed to perform an in-depth proof-ofconcept
for a high dose rate, high precision converging beam small animal irradiation platform.
In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for
high output and high directionality was designed and characterized. In the second aim, an
optimization algorithm was developed to customize a collimator geometry for this unique Xray
source to simultaneously maximize the irradiator’s intensity and precision. Then, a full
converging beam irradiator apparatus was fit with a multitude …
Statistical Methods For Resolving Intratumor Heterogeneity With Single-Cell Dna Sequencing, Alexander Davis
Statistical Methods For Resolving Intratumor Heterogeneity With Single-Cell Dna Sequencing, Alexander Davis
Dissertations & Theses (Open Access)
Tumor cells have heterogeneous genotypes, which drives progression and treatment resistance. Such genetic intratumor heterogeneity plays a role in the process of clonal evolution that underlies tumor progression and treatment resistance. Single-cell DNA sequencing is a promising experimental method for studying intratumor heterogeneity, but brings unique statistical challenges in interpreting the resulting data. Researchers lack methods to determine whether sufficiently many cells have been sampled from a tumor. In addition, there are no proven computational methods for determining the ploidy of a cell, a necessary step in the determination of copy number. In this work, software for calculating probabilities from …
An Information Theory Model For Optimizing Quantitative Magnetic Resonance Imaging Acquisitions, Drew Mitchell
An Information Theory Model For Optimizing Quantitative Magnetic Resonance Imaging Acquisitions, Drew Mitchell
Dissertations & Theses (Open Access)
Quantitative magnetic resonance imaging (qMRI) is a powerful group of imaging techniques with a growing number of clinical applications, including synthetic image generation in post-processing, automatic segmentation, and diagnosis of disease from quantitative parameter values. Currently, acquisition parameter selection is performed empirically for quantitative MRI. Tuning parameters for different scan times, tissues, and resolutions requires some measure of trial and error. There is an opportunity to quantitatively optimize these acquisition parameters in order to maximize image quality and the reliability of the previously mentioned methods which follow image acquisition.
The objective of this work is to introduce and evaluate a …
Modelling Β2ar Regulation, Sharat J. Vayttaden
Modelling Β2ar Regulation, Sharat J. Vayttaden
Dissertations & Theses (Open Access)
The β2 adrenergic receptor (β2AR) regulates smooth muscle relaxation in the vasculature and airways. Long- and Short-acting β-agonists (LABAs/SABAs) are widely used in treatment of chronic obstructive pulmonary disorder (COPD) and asthma. Despite their widespread clinical use we do not understand well the dominant β2AR regulatory pathways that are stimulated during therapy and bring about tachyphylaxis, which is the loss of drug effects. Thus, an understanding of how the β2AR responds to various β-agonists is crucial to their rational use. Towards that end we have developed deterministic models that explore the mechanism of drug- induced β2AR regulation. These mathematical models …