Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Applied Mathematics
A Physiologically-Based Pharmacokinetic Model For The Antibiotic Levofloxacin, Paezha M. Mccartt
A Physiologically-Based Pharmacokinetic Model For The Antibiotic Levofloxacin, Paezha M. Mccartt
Undergraduate Honors Theses
Levofloxacin is in a class of antibiotics known as fluoroquinolones, which treat infections by killing the bacteria that cause them. A physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake, distribution, and elimination of Levofloxacin after a single dose. PBPK modeling uses parameters such as body weight, blood flow rates, partition coefficients, organ volumes, and several other parameters in order to model the distribution of a particular drug throughout the body. Levofloxacin is only moderately bound in human blood plasma, and, thus, for the purposes of this paper, linear bonding is incorporated into the model because the free or …