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Applied Mathematics Commons

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Full-Text Articles in Applied Mathematics

Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost Dec 2023

Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost

All Dissertations

In confocal single-molecule FRET experiments, the joint distribution of FRET efficiency and donor lifetime distribution can reveal underlying molecular conformational dynamics via deviation from their theoretical Forster relationship. This shift is referred to as a dynamic shift. In this study, we investigate the influence of the free energy landscape in protein conformational dynamics on the dynamic shift by simulation of the associated continuum reaction coordinate Langevin dynamics, yielding a deeper understanding of the dynamic and structural information in the joint FRET efficiency and donor lifetime distribution. We develop novel Langevin models for the dye linker dynamics, including rotational dynamics, based …


An Exposition Of The Curvature Of Warped Product Manifolds, Angelina Bisson Dec 2023

An Exposition Of The Curvature Of Warped Product Manifolds, Angelina Bisson

Electronic Theses, Projects, and Dissertations

The field of differential geometry is brimming with compelling objects, among which are warped products. These objects hold a prominent place in differential geometry and have been widely studied, as is evident in the literature. Warped products are topologically the same as the Cartesian product of two manifolds, but with distances in one of the factors in skewed. Our goal is to introduce warped product manifolds and to compute their curvature at any point. We follow recent literature and present a previously known result that classifies all flat warped products to find that there are flat examples of warped products …


Stability Of Cauchy's Equation On Δ+., Holden Wells Aug 2023

Stability Of Cauchy's Equation On Δ+., Holden Wells

Electronic Theses and Dissertations

The most famous functional equation f(x+y)=f(x)+f(y) known as Cauchy's equation due to its appearance in the seminal analysis text Cours d'Analyse (Cauchy 1821), was used to understand fundamental aspects of the real numbers and the importance of regularity assumptions in mathematical analysis. Since then, the equation has been abstracted and examined in many contexts. One such examination, introduced by Stanislaw Ulam and furthered by Donald Hyers, was that of stability. Hyers demonstrated that Cauchy's equation exhibited stability over Banach Spaces in the following sense: functions that approximately satisfy Cauchy's equation are approximated with the same level of error by functions …


Topological Data Analysis Of Weight Spaces In Convolutional Neural Networks, Adam Wagenknecht Apr 2023

Topological Data Analysis Of Weight Spaces In Convolutional Neural Networks, Adam Wagenknecht

Dissertations

Convolutional Neural Networks (CNNs) have become one of the most commonly used tools for performing image classification. Unfortunately, as with most machine learning algorithms, CNNs suffer from a lack of interpretability. CNNs are trained by using a training data set and a loss function to tune a set of parameters known as the layer weights. This tuning process is based on the classical method of gradient descent, but it relies on a strong stochastic component, which makes the weight behavior during training difficult to understand. However, since CNNs are governed largely by the weights that make up each of the …