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Vitamin D Status Is Not Associated With Risk Of Early Menopause, Alexandra C. Purdue-Smith, Brian W. Whitcomb, Joann E. Manson, Susan E. Hankinson, Lisa M. Troy, Bernard A. Rosner, Elizabeth R. Bertone-Johnson
Vitamin D Status Is Not Associated With Risk Of Early Menopause, Alexandra C. Purdue-Smith, Brian W. Whitcomb, Joann E. Manson, Susan E. Hankinson, Lisa M. Troy, Bernard A. Rosner, Elizabeth R. Bertone-Johnson
Biostatistics and Epidemiology Faculty Publications Series
Background: Early natural menopause, the cessation of ovarian function before age 45 y, is positively associated with cardiovascular disease and other conditions. Dietary vitamin D intake has been inversely associated with early menopause; however, no previous studies have evaluated risk with regard to plasma 25-hydroxyvitamin D [25(OH)D] concentrations.
Objective: We prospectively evaluated associations of total and free 25(OH)D and vitamin D–binding protein (VDBP) concentrations and the risk of early menopause in a case-control study nested within the Nurses’ Health Study II (NHS2). We also considered associations of 25(OH)D and VDBP with anti-Müllerian hormone (AMH) concentrations.
Methods: The NHS2 is a …