Physical Sciences and Mathematics Commons^™

Rfx2 Is A Candidate Downstream Amplifier Of A-Myb Regulation In Mouse Spermatogenesis, Gary C. Horvath, Malathi K. Kistler, Wilson Stephen Kistler

Faculty Publications

Background: Mammalian spermatogenesis involves formation of haploid cells from the male germline and then a complex morphological transformation to generate motile sperm. Focusing on meiotic prophase, some tissue-specific transcription factors are known (A-MYB) or suspected (RFX2) to play important roles in modulating gene expression in pachytene spermatocytes. The current work was initiated to identify both downstream and upstream regulatory connections for Rfx2.

Results: Searches of pachytene up-regulated genes identified high affinity RFX binding sites (X boxes) in promoter regions of several new genes: Adam5, Pdcl2, and Spag6. We confirmed a strong promoter-region X-box for Alf, a germ cell-specific variant of …

Empirical Mode Decomposition Operator For Dewowing Gpr Data, Bradley M. Battista, Adrian Addison, Camelia C. Knapp

Faculty Publications

Signal processing tools available to ground penetrating radar data used for shallow subsurface imaging and hydrogeophysical parameter estimation are significantly handled using the same tools available to seismic reflection data. Overall, the same tools produce interpretable images from both data types, but particular noise (wow noise) in electromagnetic data must be removed before stable and accurate quantitative results can be produced. Wow noise is an inherent, nonlinear electromagnetic interference and a significant component of GPR data. Further, the nonlinear and non-stationary nature of wow noise provides a strong argument for preprocessing radar traces with time-domain operators. Time-domain operators designed for …

Improved Hydrogeophysical Parameter Estimation From Empirical Mode Decomposition Processed Ground Penetrating Radar Data, Adrian Addison, Bradley M. Battista, Camelia C. Knapp

Faculty Publications

Various techniques have been designed to maximize the use of ground penetrating radar (GPR) as an exploration tool. Improvements in signal processing are expected to further facilitate the accuracy of parameters derived from using GPR in certain geologic environments. Common-offset GPR data were collected at the Marine Corps Air Station (MCAS) in Beaufort, South Carolina, and dielectric constants were calculated following the application of the empirical mode decomposition (EMD) for dewowing GPR traces. Conventional signal processing is applied to the GPR traces to provide hydrogeophysical parameter estimates such as volumetric water content, porosity, and hydraulic conductivity. The results are validated …

A Measurement Of Coherent Neutral Pion Production In Neutrino Neutral Current Interactions In The Nomad Experiment, C. T. Kullenberg, S. R. Mishra, M. B. Seaton, J. J. Kim, X. C. Tian, A. M. Scott, M. Kirsanov, Roberto Petti, S. Alekhin, P. Astier, D. Autiero, A. Baldisseri, M. Baldo-Ceolin, M. Banner, G. Bassompierre, K. Benslama, N. Besson, I. Bird, B. Blumenfeld, F. Bobisut, Et. Al.

Faculty Publications

We present a study of exclusive neutral pion production in neutrino–nucleus Neutral Current interactions using data from the NOMAD experiment at the CERN SPS. The data correspond to 1.44 X 10⁶ muon-neutrino Charged Current interactions in the energy range 2.5 ≤ E _v & ≤ 300GeV. Neutrino events with only one visible π⁰ in the final state are expected to result from two Neutral Current processes: coherent π⁰ production, v + A

Wavepacket Approach To The Cumulative Reaction Probability Within The Flux Operator Formalism, Sophya Garashchuk, Tijo Vazhappilly

Faculty Publications

Expressions for the singular flux operator eigenfunctions and eigenvalues are given in terms of the Dirac δ-function representable as a localized Gaussian wavepacket. This functional form enables computation of the cumulative reaction probability N(E) from the wavepacket time-correlation functions. The Gaussian based form of the flux eigenfunctions, which is not tied to a finite basis of a quantum-mechanical calculation, is particularly useful for approximate calculation of N(E) with the trajectory based wavepacket propagation techniques. Numerical illustration is given for the Eckart barrier using the conventional quantum-mechanical propagation and the quantum trajectory dynamics with the approximate quantum potential. N(E) converges with …

Radiatively Induced Lorentz And Gauge Symmetry Violation In Electrodynamics With Varying Alph A, Alejandro Ferrero, Brett David Altschul

Faculty Publications

A time-varying fine structure constant α(t) could give rise to Lorentz- and CPT-violating changes to the vacuum polarization, which would affect photon propagation. Such changes to the effective action can violate gauge invariance, but they are otherwise permitted. However, in the minimal theory of varying α, no such terms are generated at lowest order. At second order, vacuum polarization can generate an instability—a Lorentz-violating analogue of a negative photon mass squared −m²γ∝α(˙α2α)²log(Λ²), where Λ is the cutoff for the low-energy effective theory.

Succination Of Thiol Groups In Adipose Tissue Proteins In Diabetes: Succination Inhibits Polymerization And Secretion Of Adiponectin, Norma Frizzell, Mathur Rajesh, Matthew J. Jepson, Ryoji Nagai, James A. Carson, Suzanne R. Thorpe, John W. Baynes

Faculty Publications

S-(2-Succinyl)cysteine (2SC) is formed by reaction of the Krebs cycle intermediate fumarate with cysteine residues in protein, a process termed succination of protein. Both fumarate and succination of proteins are increased in adipocytes cultured in high glucose medium (Nagai, R., Brock, J. W., Blatnik, M., Baatz, J. E., Bethard, J., Walla, M. D., Thorpe, S. R., Baynes, J. W., and Frizzell, N. (2007) J. Biol. Chem. 282, 34219-34228). We show here that succination of protein is also increased in epididymal, mesenteric, and subcutaneous adipose tissue of diabetic (db/db) mice and that adiponectin is a major target for succination in both …

Memristive Model Of Amoeba Learning, Yuriy V. Pershin Dr, Steven La Fontaine, Massimiliano Di Ventra

Faculty Publications

Recently, it was shown that the amoebalike cell Physarum polycephalum when exposed to a pattern of periodic environmental changes learns and adapts its behavior in anticipation of the next stimulus to come. Here we show that such behavior can be mapped into the response of a simple electronic circuit consisting of a LC contour and a memory-resistor (a memristor) to a train of voltage pulses that mimic environment changes. We also identify a possible biological origin of the memristive behavior in the cell. These biological memory features are likely to occur in other unicellular as well as mutlicellular organisms, albeit …

Cardiac And Renal Function Are Progressively Impaired With Aging In Zucker Diabetic Fatty Type Ii Diabetic Rats, John W. Baynes, David B. Murray

Faculty Publications

This study investigated the temporal relationship between cardiomyopathy and renal pathology in the type II diabetic Zucker diabetic fatty (ZDF) rat. We hypothesized that changes in renal function will precede the development of cardiac dysfunction in the ZDF rat. Animals (10 weeks old) were divided into four experimental groups: Lean Control (fa/?) LC(n = 7), untreated ZDF rats (n = 7) sacrificed at 16 weeks of age, and LC (n = 7) untreated ZDF rats (n = 9) sacrificed at 36 weeks of age. LV structural/functional parameters were assessed via Millar conductance catheter. Renal function was evaluated via markers of …

Revised Crustal Architecture Of The Southeastern Carpathian Foreland From Active And Passive Seismic Data, Dana M. Enciu, Camelia C. Knapp, James H. Knapp

Faculty Publications

Integration of active and passive source seismic data is employed in order to study the nature of the relationships between crustal seismicity and geologic structures in the southeastern (SE) Carpathian foreland of Romania and the possible connection with the Vrancea Seismogenic Zone (VSZ) of intermediatedepth seismicity, one of the most active earthquakeprone areas in Europe. Crustal epicenters and focal mechanisms are correlated with four deep industry seismic profiles, the reprocessed Danube and Carpathian Integrated Action on Process in the Lithosphere and Neotectonics (DACIA PLAN) profile and the Deep Reflection Acquisition Constraining Unusual Lithospheric Activity II and III (DRACULA) profiles in …

Cyclic Shifts Of The Van Der Corput Set, Dmitriy Bilyk

Faculty Publications

In 1980, K. Roth showed that the expected value of the L2 discrepancy of the cyclic shifts of the N-point van der Corput set is bounded by a constant multiple of √logN, thus guaranteeing the existence of a shift with asymptotically minimal L2 discrepancy. In the present paper, we construct a specific example of such a shift.

Spin Polarization Control By Electric Stirring: Proposal For A Spintronic Device, Yuriy V. Pershin Dr, N. A. Sinitsyn, A. Kogan, A. Saxena, D. L. Smith

Faculty Publications

We propose a spintronic device to generate spin polarization in a mesoscopic region by purely electric means. We show that the spin Hall effect in combination with the stirring effect are sufficient to induce measurable spin polarization in a closed geometry. Our device structure does not require the application of magnetic fields, external radiation or ferromagnetic leads, and can be implemented in standard semiconducting materials.

A Space Topologized By Functions From Omega To Omega, Akira Iwasa

Faculty Publications

No abstract provided.

Probability Density Functions For Snir In Ds-Cdma, David W. Matolak

Faculty Publications

Analytical expressions for the probability density function of block-wise signal-to-noise-plus-interference ratio for both synchronous and asynchronous direct-sequence spread spectrum code-division multiple access systems are developed, for equal average energy signals on the Gaussian and Rayleigh flat fading channels. Using the standard Gaussian approximation for multi-user interference, accurate density approximations are obtained, which agree very well with computer simulation results.

Bounding Isotropic Lorentz Violation Using Synchrotron Losses At Lep, Brett David Altschul

Faculty Publications

Some deviations from special relativity—especially isotropic effects—are most efficiently constrained using particles with velocities very close to 1. While there are extremely tight bounds on some of the relevant parameters coming from astrophysical observations, many of these rely on our having an accurate understanding of the dynamics of these high-energy sources. It is desirable to have reliable laboratory constraints on these same parameters. The fastest-moving particles in a laboratory were electrons and positrons at LEP. The energetics of the LEP beams were extremely well understood, and measurements of the synchrotron emission rate indicate that the isotropic Lorentz violation coefficient |˜κ …

Frequency Doubling And Memory Effects In The Spin Hall Effect, Yuriy V. Pershin Dr, Massimiliano Di Ventra

Faculty Publications

We predict that when an alternating voltage is applied to a semiconducting system with inhomogeneous electron density in the direction perpendicular to main current flow, the spin Hall effect results in a transverse voltage containing a double-frequency component. We also demonstrate that there is a phase shift between applied and transverse-voltage oscillations, related to the general memristive behavior of semiconductor spintronic systems. A different method to achieve frequency doubling based on the inverse spin Hall effect is also discussed.

Controlled Assembly Of Rodlike Viruses With Polymers, Tao Li, Laying Wu, Nisaraporn Suthiwangcharoen, Michael A. Bruckman, Dayton Cash, Joan S. Hudson, Soumitra Ghoshroy, Qian Wang

Faculty Publications

A practical method to assemble rodlike tobacco mosaic virus and bacteriophage M13 with polymers was developed, which afforded a 3D core–shell composite with morphological control.

Mammaglobin As A Potential Molecular Target For Breast Cancer Drug Delivery, Lian Zuo, Ly Li, Qian Wang, Timothy P. Fleming, Shaojin You

Faculty Publications

Background Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associated with the surface of breast cancer cells, which strongly disputes the therapeutic strategies. Results We conducted a computer-based predictive analysis and identified a small fragment at the N-end of MAM as a potential transmembrane domain. We provided several evidences to demonstrate the presence of the membrane-associated MAM. We isolated the membrane protein components from …

Tobacco Mosaic Virus Templated Synthesis Of One Dimensional Inorganic–Polymer Hybrid Fibres, Jianhua Rong, Fiona Oberbeck, Xinnan Wang, Xiaodong Li, Jerry Oxsher, Zhongwei Niu, Qian Wang

Faculty Publications

Inorganic–polymer hybrid nanofibres were prepared by using a rod-like tobacco mosaic virus (TMV) as a template. With tetraethylorthosilicate (TEOS) as a precursor, long silica-coated TMVfibres were formed via a head-to-tail assembly, which showed a substantial increase of the elastic modulus. Furthermore, homogenous titania–TMV hybrid fibres could be prepared using polyaniline-coated TMV fibres as a template, which were used to form a composite film that was able to sense liquefied petroleum gases.

Macrospin Model To Explain The Absence Of Preswitching Oscillations In Magnetic Tunnel Junctions: Fieldlike Spin-Transfer Torque, Samir Garzon, Yaroslaw Bazaliy, Richard A. Webb, Mark Covington, Shehzaad Kaka, Thomas M. Crawford

Faculty Publications

We show that the absence of preswitching oscillations (“incubation delay”) in magnetic tunnel junctions can be explained within the macrospin model by a sizable fieldlike component of the spin-transfer torque. It is further suggested that measurements of the voltage dependence of tunnel junction switching time in the presence of external easy axis magnetic fields can be used to determine the magnitude and voltage dependence of the fieldlike torque.

Tetraquabis(5-Fluorosaccharinato)Nickel(Ii), Larnelle Peterson, Jennifer Kelley, Leroy Peterson Jr., Mark D. Smith, Hans-Conrad Zur Loye

Faculty Publications

In the centrosymmetric title complex, [Ni(C₇H₃FNO₃S)₂(H₂O)₄], the Ni^II atom exhibits a slightly distorted trans-NiN₂O₄ octahedral coordination. The nitrogen donors are provided by two 5-fluorosaccharinate ligands and the oxygen donors are provided by four water molecules. The crystal structure features O-HO and bifurcated O-H(F,O) hydrogen bonds, the latter involving the F atom of the 5-fluorosaccharinate ligand.

Developing A Robust Geologic Conceptual Model Using Pseudo 3-D P-Wave Seismic Reflection Data, Adrian Addison, Michael G. Waddell, Camelia C. Knapp, Duke T. Brantley, John M. Shafer

Faculty Publications

As part of a multiscale hydrogeophysical and modeling study, a pseudo three-dimensional (3-D) seismic surveywas conducted over a contaminant plume at P area, Savannah River site (South Carolina), to enhance the existing geologicmodel by resolving uncertainties in the lithostratigraphic sequence. The geometry of the dissolved phase trichloroethylene plume, based on initial site characterization, appears to be confined to a narrow corridor within the Eocene sand overlying a clay unit approximately 25m(82 ft) below land surface. Processing the seismic data as a 3-D data volume instead of a series of closely spaced two-dimensional lines allowed for better interpretation of the target …

Diaquabis(5-Fluoro-2-Hydroxybenzoato-Κo1)Zinc(Ii), Diana Rishmawi, Jennifer Kelley, Mark D. Smith, Leroy Peterson, Hans-Conrad Zur Loye

Faculty Publications

The title compound, [Zn(C₇H₄FO₃)₂(H₂O)₂], is a monomeric Zn^II complex. The Zn^II atom, which lies on a twofold rotation axis, is situated in a distorted tetrahedral environment composed of two monodentate carboxlyate O atoms and two water O atoms. O-HO hydrogen bonds link these units, forming sheets that are stacked along the c axis.

Disentangling Forms Of Lorentz Violation With Complementary Clock Comparison Experiments, Brett David Altschul

Faculty Publications

Atomic clock comparisons provide some of the most precise tests of Lorentz and CPT symmetries in the laboratory. With data from multiple such experiments using different nuclei, it is possible to constrain new regions of the parameter space for Lorentz violation. Relativistic effects in the nuclei allow us to disentangle forms of Lorentz violation which could not be separately measured in purely nonrelativistic experiments. The disentangled bounds in the neutron sectors are at the 10⁻²⁸ GeV level, far better than could be obtained with any other current technique.

Downregulation Of Hiv-1 Vif By A Hammerhead Ribozyme Expressed From A Retroviral Vector, Audrey M. Hendley, William Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

Synthesis Of Fatty Acid Binding Protein Inhibitors: A New Approach For Diabetes Treatment, Shekelia Baccus, M. Perry Davis Jr, David R. Magnin

Journal of the South Carolina Academy of Science

No abstract provided.

Effect Of Thaw Temperature On Murine Blastocyst Development, Heather M. Barton, H. Lee Higdon Iii, Ph.D., Jennifer E. Graves-Herring M.S., William R. Boone, Ph.D.

Journal of the South Carolina Academy of Science

No abstract provided.

Generation Of A Retroviral Vector That Expresses An Anti-Hiv-1 Tat Hammerhead Ribozyme, Lindsey E. Padgett, William H. Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

Where Do Mouse Embryos Thrive Best? Comparison Of Mammalian Embryo Development Under Varying Laboratory Environments, Yvonne K. Kao, H. Lee Higdon Iii, Ph.D, Jennifer E. Graves-Herring , M.S., William R. Boone Ph.D

Journal of the South Carolina Academy of Science

No abstract provided.

Temperature Changes Resulting From A Gaalas Laser In The Decontamination Of A Failing Dental Implant, Adam B. Oppenheimer

Journal of the South Carolina Academy of Science

No abstract provided.