Physical Sciences and Mathematics Commons^™

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

Geometric Photoisomer Investigation Of Bilirubin (Z,Z)-Ixα, Robert Howe Walker Iii

Chemistry & Biochemistry Theses & Dissertations

Numerous investigations of bilirubin have been reported in the literature. Correlation among these investigations can not be made because of multiple behavioral changes characteristic of the solubilized pigment. This research was initiated to evaluate bilirubin and its associated isomers in identical chemical environments.

Two different solvent systems were experimentally selected to study chemical behavior of bilirubin and occurring photoisomers. A ternary solution consisting of 1:3:1 chloroform:methanol:water was used exclusively in visible spectrophotometric analyses. Also, a pH 10.00 buffer was utilized. This latter system has successfully been used in spectrophotometric and voltammetric work.

Four different photochemical processes have been detected spectrophotometrically, …

Nonadiabatic Theory Of Fine-Structure Branching Cross Sections For Na-He, Na-Ne, And Na-Ar Optical Collisions, Linda L. Vahala, P. S. Julienne, Mark D. Havey

Electrical & Computer Engineering Faculty Publications

The nonadiabatic close-coupled theory of atomic collisions in a radiation field is generalized to include electron spin and is used to consider the weak-field Na–rare-gas (RG) optical collision Na(²S_1/2)+RG+nhν μNa(²P_j)+RG+(n-1)hν. The effects of detuning and incident energy on the branching into the atomic Na 3p²P_3/2 and 3p²P_1/2 states are examined. The cross sections σ(j) are found to have a strong asymmetry between red and blue detuning as well as a complex threshold and resonance structure dependence on energy. A partial cross-section analysis …