Physical Sciences and Mathematics Commons^™

Distributed Load Testing By Modeling And Simulating User Behavior, Chester Ira Parrott

LSU Doctoral Dissertations

Modern human-machine systems such as microservices rely upon agile engineering practices which require changes to be tested and released more frequently than classically engineered systems. A critical step in the testing of such systems is the generation of realistic workloads or load testing. Generated workload emulates the expected behaviors of users and machines within a system under test in order to find potentially unknown failure states. Typical testing tools rely on static testing artifacts to generate realistic workload conditions. Such artifacts can be cumbersome and costly to maintain; however, even model-based alternatives can prevent adaptation to changes in a system …

Synthesis Of Structurally Diverse Molecular Scaffolds Enabled By Protected Oxyallyl Cations, Joshua Andrew Malone

LSU Doctoral Dissertations

This dissertation focuses on the synthesis of diverse molecular scaffolds through the use of protected oxyallyl cation intermediates. Chapter One provides background on the generation and applications of oxyallyl and silyloxyallyl cations, while focusing on the direct nucleophilic capture of theses intermediates to generate functionalized ketones and silylenolates. Chapter Two depicts our approach to generate six-membered silyloxyallyl cations through the use of mild Brønsted acid activation. Regioselective nucleophilic capture of these intermediates successfully produced diverse a,a’-substituted silylenol ethers enabled by polar solvent and residual water.

Chapter three details strategies to generate 1,4-dicarbonyl compounds, focusing on the capture of cationic intermediates …

Measurements And Mitigation Of Scattered Light Noise In Ligo, Corey Daniel Austin

LSU Doctoral Dissertations

The Advanced LIGO (aLIGO) detectors use 1064 nm lasers to measure the tiny fluctuations in spacetime that occur when gravitational waves pass through the earth. LIGO makes use of advanced coating methods and materials to limit the amount of light that scatters from the main beam, but some amount of light does scatter. This stray light can interact with surfaces inside the interferometer that are not seismically isolated and then recombine with the main beam, introducing excess noise into the gravitational wave channel. This thesis reviews the methods for modeling scattered light with ray tracing software and analytical models, for …

Deep-Ultraviolet Laser Ablation For Biomolecular Analysis, Oluwaremilekun Omowunmi Lawal

LSU Doctoral Dissertations

New sampling and ionization techniques were developed using a deep-ultraviolet (DUV) laser at 193 nm wavelength for analysis of large biomolecules. A micrometer spatial resolution DUV laser ablation and capture system was constructed to sample tissue biomolecules. The spot size measurements of the focused beam showed that subcellular spots with ca. 2 μm diameter can be readily achieved with this wavelength. To demonstrate the extraction of tissue biomolecules with the DUV laser, regions of tissue sections were ablated and captured for offline proteomic and genomic analysis. The proteomic studies revealed that the tissue proteins were ejected without fragmentation and that …

Structure And Dynamics Of Phospholipid Vesicles And The Dependence On Nanoscale Interactions With Molecules Of Varying Complexity, Lakshapathy Widanelage Judith Upeka De Mel

LSU Doctoral Dissertations

In this dissertation, molecular interactions and changes imposed by nano-scale structures on phospholipid vesicles were investigated. 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) large unilamellar vesicles (LUVs) were used as the model system. Understanding changes of the bilayer structure, interfacial properties, lipid dynamics, and self-assembly, allows bridging relationships between biological cell membrane structure and dynamics to cellular functionalities. For example, membrane curvature changes are linked to membrane protein functions, although the exact mechanisms of control are not yet understood. Moreover, the knowledge gained from vesicle models allows exploring novel strategies for drug delivery applications. To achieve this, DOPC LUVs were synthesized and characterized by a …

Computational Investigations Of Battery Electrolytes, Ke Li

LSU Doctoral Dissertations

In this dissertation, the structure and dynamics of battery electrolytes were investigated using atomistic molecular dynamics (MD) simulations. Battery electrolytes play a key role in transporting ions between the cathode and anode. The chemical stability and ionic conductivity of electrolytes influence battery performance. In order to design better electrolytes, one needs an understanding of the relationship between electrolyte structure, dynamics, and bulk properties. To bridge the gap between the macroscopic phenomenon and the hidden molecular physics, in the first project we focused on probing an ether-based electrolyte, chosen for its relevance in sodium-based batteries. Through studying the impact of concentration …

Development Of Reduced Order Models Using Reservoir Simulation And Physics Informed Machine Learning Techniques, Mark V. Behl Jr

LSU Master's Theses

Reservoir simulation is the industry standard for prediction and characterization of processes in the subsurface. However, simulation is computationally expensive and time consuming. This study explores reduced order models (ROMs) as an appropriate alternative. ROMs that use neural networks effectively capture nonlinear dependencies, and only require available operational data as inputs. Neural networks are a black box and difficult to interpret, however. Physics informed neural networks (PINNs) provide a potential solution to these shortcomings, but have not yet been applied extensively in petroleum engineering.

A mature black-oil simulation model from Volve public data release was used to generate training data …

Detrital Zircon (U-Th)/He Thermochronology In The Greater Caucasus: Implications For Thermal And Tectonic History Along-Strike, Kate Gutterman

LSU Master's Theses

Located along the northernmost boundary of the Arabia-Eurasia collision zone, the Greater Caucasus are a young, actively deforming mountain range striking WNW-ESE between the Black and Caspian Seas. Previous thermochronometric studies predominantly focused on the western portion of the range partially constrain the thermal and tectonic history of the Greater Caucasus. However, due to the complex nature of the tectonics in the region, multiple competing tectonic models have been suggested to explain the exact timing of collision and onset of rapid uplift. Furthermore, the Greater Caucasus exhibit competing along-strike gradients in modern shortening rates, mean annual precipitation, structural architecture and …

U/Pb Zircon Ages Of Felsic Veins In The Sawtooth Metamorphic Complex, Idaho, U.S.A: Implications For Magmatism And Vein Source, Kyle Tollefson

LSU Master's Theses

Veins associated with igneous activity provide numerous insights into the geologic history of an area. The Sawtooth Metamorphic Complex (SMC) in Idaho is a roof pendent of highgrade rocks cross-cut by numerous felsic veins of unknown age and source. Obtaining U/Pb zircon geochronology of these veins can facilitate understanding the ages of magmatism in the region, their source, when nearby batholiths were juxtaposed to the SMC, and provide additional insights into the geologic evolution of the area. Each potential source of these veins has a distinct age: the Sawtooth batholith (ca. 47 Ma), the Idaho batholith (98-53 Ma), an anatectic …

Adsorption And Reconfiguration Of Amphiphiles At Silica-Water Interfaces: Role Of Electrostatic Interactions, Van Der Waals Forces And Hydrogen Bonds, Yao Wu

LSU Doctoral Dissertations

The ability to explore and predict metastable structures of hybrid self-assemblies is of central importance for the next generation of advanced materials with novel properties. As compared to their thermodynamically stable forms, the kinetically stabilized materials show improved functionality potentially over their stable counterparts. The self-assembly processes usually originate from weak intermolecular interactions, involving a dynamic competition between attractive and repulsive interactions. These weak forces, including van der Waals (vdW), electrostatic interaction and the hydrogen bonding (H-bonding), can be tuned by external stimuli, e.g., confinement, temperature and ionization, and consequently driving hybrid materials into different configurations. It is challenging to …

Methods For 1,2-Cis-Selective O-Glycosylation And Synthesis Of An A. Baumannii Lipooligosaccharide Core Disaccharide, Ashley Fulton

LSU Doctoral Dissertations

This dissertation focuses on the formation of organic thin films on gold surfaces and synthesis of oligosaccharides. Chapter one, is a brief introduction on the utility of thin films, as well as ways to characterize thin films, as well as, a report on the attempt to form organic thin films on Au(111) surfaces using photoredox catalysis.

Glycoconjugates on cell surfaces serve as important mediators of intercellular recognition, adhesion, and viral infection. Due to the significant role that glycoconjugates play on the surface of cells, oligosaccharide synthesis is of great interest. Chapter two, is an extensive review of oligosaccharide synthesis, its …

Synthesis And Investigation Of Amphiphilic Polypeptoids For Environmental And Biological Applications, Tianyi Yu

LSU Doctoral Dissertations

Polypeptoids are an emerging class of peptidomimetic polymers featuring N-substituted polyglycine backbones. Polypeptoids are cyto-compatible and backbone degradable, making them appealing to many biological applications. When the highly polar polyamide backbone is coupled with non-polar aliphatic side chains, polypeptoids can be considered as facial amphiphiles. Without extensive hydrogen bonding along the backbone, the conformation of polypeptoid is largely controlled by the N-substituent structures. The hydrophobicity-lipophilicity balance of polypeptoids can be readily tuned with the N-substituent structures as well as the molar ratio between the hydrophilic and hydrophobic segments in their copolymers. In view of these combined attributes, …

A Study Of 26al(P, Γ)27si With The Silicon Array For Branching Ratio Experiments (Sabre), Erin Courtney Good

LSU Doctoral Dissertations

The observation of the radioisotope ²⁶Al is an indicator of ongoing nucleosynthesis in the Galaxy due to its short lifetime (t_1/2 = 7.2 × 10⁵ yr) on Galactic timescales. It is thought to be synthesized in several different environments in our Galaxy, one of which is in classical novae. Classical novae are stellar explosions that occur on the surface of a white dwarf in a binary system with a main sequence star. The isotopic production resulting from the nucleosynthesis that drives these explosions can be modeled with the input of nuclear reaction rates. In recent years, many …

A Modelling Study For Smart Pigging Technique For Pipeline Leak Detection, Caitlyn Judith Thiberville

LSU Master's Theses

Although leak incidents continue, a pipeline remains the most reliable mode of transportation within the oil and gas industry. It becomes even more important today because the projection for new pipelines is expected to increase by 1 billion BOE through 2035. In addition, increasing number and length of subsea tiebacks face new challenges in term of data acquisition, monitoring, analysis, and remedial actions. Passive leak-detection methods commonly used in the industry have been successful with some limitations in that they often cannot detect small leaks and seeps. In addition to a thorough review of related topics, this study investigates how …

Demographic Impacts Of Climate-Induced Migration And Environmental Shocks And Stressors In Cameron Parish, Louisiana, John Green Iii

Honors Theses

No abstract provided.

Increasing The Bioavailability Of Poorly Soluble Anti-Cancer Prodrugs Through Encapsulation In Platinum Based Nanocages, Salim Cesar Lutfallah

Honors Theses

No abstract provided.

Correlation Analysis Of Precipitation And River Flow With The Injection And Discharge Of The Three Gorges Dam And Reservoir, Lirong Yin

LSU Master's Theses

The Yangtze River has been the primary support of the resources and transportation of China. Its basin covers an area of 1.8 million square kilometers. The Three Gorges Dam and Reservoir on the Yangtze River is one of the world's largest dams. After the dam construction in 1997, the reservoir started injecting the reservoir to a size of over 600 km². The influence caused by the dam and reservoir on the river system has been overwhelming and destructive. The possible influence of this vast water body and the operation to maintain this waterbody's size and water level on …

A Phase-Field Approach To Diffusion-Driven Fracture, Friedrich Wilhelm Alexander Dunkel

LSU Doctoral Dissertations

In recent years applied mathematicians have used modern analysis to develop variational phase-field models of fracture based on Griffith's theory. These variational phase-field models of fracture have gained popularity due to their ability to predict the crack path and handle crack nucleation and branching.

In this work, we are interested in coupled problems where a diffusion process drives the crack propagation. We extend the variational phase-field model of fracture to account for diffusion-driving fracture and study the convergence of minimizers using gamma-convergence. We will introduce Newton's method for the constrained optimization problem and present an algorithm to solve the diffusion-driven …

Adaptive Data Migration In Load-Imbalanced Hpc Applications, Parsa Amini

LSU Doctoral Dissertations

Distributed parallel applications need to maximize and maintain computer resource utilization and be portable across different machines. Balanced execution of some applications requires more effort than others because their data distribution changes over time. Data re-distribution at runtime requires elaborate schemes that are expensive and may benefit particular applications.

This dissertation discusses a solution for HPX applications to monitor application execution with APEX and use AGAS migration to adaptively redistribute data and load balance applications at runtime to improve application performance and scaling behavior. This dissertation provides evidence for the practicality of using the Active Global Address Space as is …

Using Spatial Analysis And Machine Learning Techniques To Develop A Comprehensive Highway-Rail Grade Crossing Consolidation Model, Samira Soleimani

LSU Doctoral Dissertations

The safety of highway-railroad grade crossings (HRGC) is still an issue in the United States of America (USA). The grade crossing is where a railroad crosses a road at the same level without any over or underpass. To improve the safety of crossings, the crossings’ condition should be explored from several aspects such as engineering design (speed limit, warning signs, etc.), road condition (number of lanes, surface markings, etc.), rail design (the type of track, ballast, etc.), temporal variables (weather, visibility, time of day, lightning, etc.), social variables (population, race, etc.), and last but not least, spatial variables (the type …

The Life History And Population Dynamics Of Southern Flounder, Kenneth A. Erickson

LSU Master's Theses

Southern Flounder, Paralichthys lethostigma, are a coastal, estuarine-dependent flatfish species that inhabits the Southeastern US Atlantic Ocean and Gulf of Mexico. Throughout their range, Southern Flounder are exploited by both commercial and recreational fisheries. Recently, numerous sources have expressed concerns about Southern Flounder populations, with stock assessments indicating declines in spawning stock biomass and recruitment. To estimate life history traits needed for informed management, such as age, growth, and maturity, I collected 327 Southern Flounder from Louisiana and obtained 14,184 historical records from the Louisiana Department of Wildlife and Fisheries. Using a von Bertalanffy growth equation in a Bayesian …

Seasonal Infilling And Sedimentary Characteristics In Sandy Versus Muddy Coastal Borrow Areas On The Louisiana Continental Shelf, Usa, Matthew Barley

LSU Master's Theses

Offshore sand deposits on the Louisiana Continental Shelf, such as inner shelf shoals and buried paleo-river channels, can be excavated to restore beaches and barrier islands that are rapidly deteriorating due to subsidence, sea-level rise and deficits in coastal sediment supply. Presented here is grain size, x-radiograph, and Beryllium-7 (⁷Be) derived sedimentation rates from multicores (~ 50 cm depth) retrieved from borrow areas (BAs) in contrasting depositional settings, all of which have implications for management of water quality, seafloor sedimentology, and biogeochemistry in proximal areas. Multicores were retrieved in fall 2018 at Caminada BA — a sandy energetic …

Hydrodynamics, Sediment Transport, And Water Quality Of Two Contrasting Dredge Pits On The Louisiana Shelf, Robert Bales

LSU Master's Theses

Sediment is needed for coastal restoration in Louisiana and is often excavated offshore from both mud-capped and sandy dredge pits. The mined sand from mud-capped pits, like Sandy Point which is west of modern Mississippi Delta of Louisiana, was originally from a paleo river channel and later covered by mud from modern coastal processes. Sandy pits, like Caminada pit in eastern Ship Shoal on Louisiana shelf, generally experience higher energy conditions. To better understand the post-dredging effects on hydrodynamics, sediment transport, and water quality, two tripods were deployed at Caminada and Sandy Point pits in summer 2018 and 2019, respectively, …

Modeling Anatomic Changes For Adaptive Radiotherapy In Locally Advanced Lung Cancer Patient Population, James Alexander Kavanaugh

LSU Doctoral Dissertations

Anatomic changes occurring mid-treatment for patients undergoing radiation therapy for locally advanced lung cancer can degrade the quality of the intended treatment plan. These changes include tumor regression, geometric misalignment, and lung density changes (atelectasis and pleural effusion), and are visible on the daily 3D cone beam CT (CBCT). To maintain the intended treatment quality, adaptive radiotherapy (ART) can be employed to modify the treatment plan to account for these anatomic changes. However, the evaluation on when to adapt is currently completed manually by the treating clinicians, resulting in a subjective and inconsistent application. To address these limitations, a series …

Transition Metal Complexes Of Pyridyltriazole And Bipyridine Ligands, Sen Gao

LSU Doctoral Dissertations

Four Ni(II) complexes have been obtained with the pyridyltriazole ligand, bpt, or the bis(pyridyltriazole) ligand, m-xpt, in chapter 2. This work was carried out as a comparison with the previously established coordination chemistry of copper(II) with bpt and m-xpt. Initially, the reaction between Ni(II) and bpt only produced one mononuclear compound, [Ni(bpt)₂(H₂O)₂](NO₃)₂ (1). In order to study the formation of Ni-bpt and Ni-m-xpt complexes in solution, mixtures of Ni(NO₃)₂ and ligand (m-xpt or bpt) were prepared in different ratios and …

Second Harmonic Generation Spectroscopy And Microscopy Of Liposomes, Nanoparticles, And Cells, Prakash Hamal

LSU Doctoral Dissertations

Second harmonic generation (SHG) is used to investigate the factors that impact nanoparticle-based drug-delivery applications. In the first study, molecular adsorption and transport kinetics of a positively-charged dye, malachite green isothiocyanate (MGITC), is characterized at the surface of different colloidal liposomes in water using SHG spectroscopy. The molecular interactions of MGITC is compared to our previous investigations with malachite green (MG). In comparison to MG, MGITC demonstrates stronger adsorption and faster transport through lipid membranes. Correspondingly, the SHG experimental results are in excellent agreement with the molecular dynamics (MD) simulations results. A key finding illustrates the importance of functional groups, …

Solvation Structures And Dynamics Of Small Molecules: Experimental And Computational Studies Using Carbonyl Vibrational Modes As Probe, Xiaoliu Zhang

LSU Doctoral Dissertations

Solutions are ubiquitous in both the global environment and the human body, and play a significant role in scientific research and industrial production. The structures and dynamics of solutions have been studied for centuries. However, conventional experimental methods, whose intrinsic measuring time is on the order of nanoseconds to microseconds, could not detect the fast dynamics taking place in the solution on the timescale of femto- and pico-second. In this dissertation, the ultrafast two-dimensional infrared (2DIR) spectroscopy was applied to characterize the structure and dynamics in three different types of solutions on the sub-picosecond timescale. Linear Fourier transform infrared spectroscopy …

Plant And Soil Responses To Sediment Deposition And Nutrient Enrichment In Healthy, Deteriorating, And Newly Created Coastal Marshes In Barataria Basin, Louisiana: Implications For Mississippi River Sediment Diversions, Gina N. Groseclose

LSU Master's Theses

To offset wetland loss in the Mississippi River Delta, sediment diversions that will re-introduce river water and sediment into wetlands are being planned for the lower Mississippi River. River diversions will also deliver high nutrient loads, which may reduce belowground plant productivity, reducing inputs of organic matter important for marsh accretion to keep pace with sea-level rise. However, belowground productivity responses to the combinatory effects of sediment and nutrients are unknown. To test the hypotheses that nutrient enrichment and sediment deposition interact to influence vegetation structure, belowground plant productivity and decomposition, and surface accretion, a field experiment was implemented in …

Some Results On Seymour’S Second-Neighborhood Conjecture And On Decompositions Of Graphs, Farid Bouya

LSU Doctoral Dissertations

This dissertation consists of two parts. In the first part, I examine Seymour’s Second-Neighborhood Conjecture, which states that every orientation of every simple graph has at least one vertex v such that the number of vertices of out-distance 2 from v is at least as large as the number of vertices of out-distance 1 from it. I present alternative statements of this conjecture using the language of linear algebra, the last one being completely in terms of the inverse of some matrix. In the second part of this dissertation, comprising of Chapters 2 and 3, I examine two conjectures on …

Phosphorus Variability In The Area Of Influence Of The Mid-Barataria Sediment Diversion, Peter Mates

LSU Master's Theses

Man-made levees along the lower Mississippi River prevent delivery of sediment from building and maintaining Louisiana’s coastal wetlands. The Mid-Barataria sediment diversions is designed to reintroduce Mississippi River water, sediment, and nutrients into the sediment-starved Barataria Basin. Phosphorus (P) is an important macronutrient for regulating primary production in coastal marine ecosystems. Wetlands can serve as a sink or source for phosphorus to the overlying water column through various retention and release processes, dependent on concentration. Louisiana coastal systems can be phosphorus limited due to much higher concentrations of bioavailable Nitrogen in river water. The high soluble molar N:P ( >50:1) …