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2019

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Articles 961 - 965 of 965

Full-Text Articles in Physical Sciences and Mathematics

Topovar90m: Global High-Resolution Topographic Variables For Environmental Modeling, Giuseppe Amatulli Dr. Jan 2019

Topovar90m: Global High-Resolution Topographic Variables For Environmental Modeling, Giuseppe Amatulli Dr.

Yale Day of Data

Topographical relief involves the vertical and horizontal variation of the Earth's terrain and it drives processes in hydrology, climatology, geography and ecology. Its assessment and characterization is fundamental for various types of modeling and simulation analysis. In this regard, the Multi-Error-Removed Improved Terrain (MERIT) Digital Elevation Model (DEM) currently provides the best high-resolution DEM globally available, at a 3 arc-second resolution (90m), due to the removal of multiple error components from the underlying SRTM3 and AW3D30 DEMs. To depict topographical variations worldwide, we developed a new dataset comprising different terrain features derived from the MERIT-DEM. The fully standardized topographical variables …

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Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan Jan 2019

Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan

Yale Day of Data

Whole transcriptome wide gene expression profiles in the sputum and circulation from 100 asthma patients were measured using the Affymetrix HuGene 1.0ST arrays. Unsupervised clustering analysis based on pathways from KEGG were used to identify TEA clusters of patients from the sputum gene expression profiles. The identified TEA clusters have significantly different pre-bronchodilator FEV1, bronchodilator responsiveness, exhaled nitric oxide levels, history of hospitalization for asthma and history of intubation. Evaluation of TEA clusters in children from Asthma BRIDGE cohort confirmed the identified differences in intubation and hospitalization. Furthermore, evaluation of the TH2 gene signatures suggested a much lower prevalence of …

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A Novel Pathway-Based Distance Score Enhances Assessment Of Disease Heterogeneity In Gene Expression, Yunqing Liu, Xiting Yan Jan 2019

A Novel Pathway-Based Distance Score Enhances Assessment Of Disease Heterogeneity In Gene Expression, Yunqing Liu, Xiting Yan

Yale Day of Data

Distance-based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and the relatively high correlation between genes are often encountered, so traditional distances such as Euclidean distance may not be effective at discriminating the biological differences between samples. In this study, we developed a novel computational method to assess the biological differences based on pathways by assuming that ontologically defined biological pathways in biologically similar samples have similar behavior. Application of this distance score results in more accurate, robust, and biologically meaningful clustering results in both …

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Analyzing Neuronal Dendritic Trees With Convolutional Neural Networks, Olivier Trottier, Jonathon Howard Jan 2019

Analyzing Neuronal Dendritic Trees With Convolutional Neural Networks, Olivier Trottier, Jonathon Howard

Yale Day of Data

In the biological sciences, image analysis software are used to detect, segment or classify a variety of features encountered in living matter. However, the algorithms that accomplish these tasks are often designed for a specific dataset, making them hardly portable to accomplish the same tasks on images of different biological structures. Recently, convolutional neural networks have been used to perform complex image analysis on a multitude of datasets. While applications of these networks abound in the technology industry and computer science, use cases are not as common in the academic sciences. Motivated by the generalizability of neural networks, we aim …

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Health Risk Tolerance As A Key Determinant Of (Un)Willingness To Behavior Change: Conceptualization And Scale Development, Hyoyeun Jun, Yan Jin Jan 2019

Health Risk Tolerance As A Key Determinant Of (Un)Willingness To Behavior Change: Conceptualization And Scale Development, Hyoyeun Jun, Yan Jin

International Crisis and Risk Communication Conference

After the study of testing determinants of risk tolerance affecting information sharing, this study was conducted as a second step to actually develop the scale for risk tolerance. Firstly, this study followed qualitative steps, such as in-depth interview and focus group, to capture how public describes the situation when they are tolerating the risk, when they knew what the recommended behavior is to relieve the risk. Secondly, this study collected 1000 U.S. public sample for the survey questionnaire that are the items generated from the qualitative steps.

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