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- Chemiluminescence (2)
- Organic compounds -- Synthesis (2)
- Solution (Chemistry) (1)
- 2-hydroxy-2-methylpropylidene (1)
- 6-thioguanosine (1)
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- Aromatic compounds -- Synthesis (1)
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Articles 1 - 16 of 16
Full-Text Articles in Physical Sciences and Mathematics
Structural And Functional Analysis Of Mutant Matal Homeodomains By Multidimensional Nmr Spectroscopy, David F. Ott
Structural And Functional Analysis Of Mutant Matal Homeodomains By Multidimensional Nmr Spectroscopy, David F. Ott
Honors Theses
Homeodomain proteins are transcription factors that contain a conserved 60- residue sequence, beginning with an N-terminal unstructured arm, followed by an alpha helix, a loop, and a helix-tum-helix. The yeast protein MATa1 is unusual among homeodomains in that, as a monomer, it binds very poorly to its DNA operator. However, the a1- α2 heterodimer binds to the hsg operator with 3000 times the affinity it has for nonspecific DNA. Studies have shown that most of the heterodimer's binding specificity is due to a1 rather than α2 (1,2). To identify the structural changes that transform al into a strong, sequence-specific DNA …
Self-Assembled Aggregates Of Neutral Nonlinear Optical Dyes In Smectite Clay Films, Mark Kostuk
Self-Assembled Aggregates Of Neutral Nonlinear Optical Dyes In Smectite Clay Films, Mark Kostuk
Honors Theses
The field of photonics relies on nonlinear optical (NLO) materials and their unique light interacting properties to guide and manipulate light for such uses as optical switches and optical data storage. Hybrid organic-inorganic composites offer excellent routes to such materials synthesis. We report herein the first study of neutral organic NLO chromophores adsorbed onto hectorite and laponite clay films. Seven different dyes (disperse red 1; disperse red 13; disperse red 19; disperse orange 3; disperse orange 13; disperse orange 25, and DANS, [4-dimethylamino-4' -nitrostilbene]), and two exchangeable cations (sodium and zinc), are used to create the hybrid films. The nature …
Separation Of Chiral Controlled Substances Using Capillary Electrophoresis, Tania Magoon
Separation Of Chiral Controlled Substances Using Capillary Electrophoresis, Tania Magoon
Honors Theses
The separation of the chiral narcotic propoxyphene by capillary electrophoresis (CE) is the goal of this work. A three-way collaboration between our research group, Professor lsiah Warner (LSU) and the New York State Forensic Investigation Center is underway to separate propoxyphene enantiomers and to develop a protocol for the Forensic Center. We are investigating the application of both polymer surfactants and cyclodextrins as CE additives for the separation of enantiomeric propoxyphene. We have synthesized or obtained several polymerized N-undecylenyl-L-amino acid and N-undecylenyl-L-dipeptide derivatives as a pseudo-stationary phase in capillary zone electrophoresis for the separation of chiral compounds. Though no separation …
Interactions Between Oxazine Dyes And Sodium Dodecyl Sulfate Studied By Molecular Spectroscopy, Michael R. Webb
Interactions Between Oxazine Dyes And Sodium Dodecyl Sulfate Studied By Molecular Spectroscopy, Michael R. Webb
Honors Theses
We present the results of a fundamental investigation of how the presence of surfactant affects the self-interaction of cationic laser dyes in aqueous solution. Oxazine 1 and oxazine 170 are known to form non-fluorescent H-aggregates (n-stacked dimers). The interactions of each of these laser dyes with sodium dodecyl sulfate (SDS), a micelle forming, anionic surfactant, have been examined using UV-visible absorption and fluorescence spectroscopy, fluorescence anisotropy, and Rayleigh scattering. The colors of oxazine 170 solutions are visually distinguishable into three stages: solutions with no SDS, solutions with SDS below the erne (8mM), and solutions with SDS concentrations above the erne. …
Quantification Of Nanomolar Superoxide In Aqueous Solution : Flow Injection Analysis Using The Chemiluminescent Reagent Mcla., Nathan Boland
Quantification Of Nanomolar Superoxide In Aqueous Solution : Flow Injection Analysis Using The Chemiluminescent Reagent Mcla., Nathan Boland
Honors Theses
A flow injection system using the chemiluminescent reagent 2-methyl-6-(4methoxyphenyl)- 3,7-dihydroimidazo[1,2-a]pyrazin-3-one (MCLA) was used to quantify aqueous concentrations of superoxide. Stock solutions of superoxide were produced by photolysis of a solution of 2-propanol and benzophenone. The concentration of superoxide was quantified in the stock solutions by direct measurement of the absorbance at 240 nm. Quantified additions of superoxide to the flow injection analysis system reacted with MCLA at pH 5.1 demonstrated a detection limit of 0.074 nM superoxide. Selective superoxide detection was confirmed by pH-dependent decay of superoxide, which was in excellent agreement with published rates.
Metal Ion Stabilization Of G-Tetrads Containing 6-Thioguanosine, Julia Drees
Metal Ion Stabilization Of G-Tetrads Containing 6-Thioguanosine, Julia Drees
Honors Theses
As alternative structures to the double helix, G-tetrads are thought to occur in DNA with many repeating deoxyguanosines (dG). These tetrads have one dG on each corner of a plane and can stack into tetraplexes that can be aptamers and may be found in telomeres. G-tetrads are destabilized by incorporation of 6-thiodeoxyguanosine (?sdG). Addition of metal ions that bind sulfur may stabilize these ?sdG-tetrads. We have carried out a survey of metal ion titrations into ?sG. Stable ?sG:MD? complexes were found for Hg2? (2:1), Cd2? (4:1), Ag2? (0.7:1) and Pt2? (thought to be 2:1). UV/Visible spectrophotometry indicates that G-tetrads containing …
Photochemical Generation And Intramolecular Chemistry Of 2-Hydroxy-2-Methylpropylidene, Robin Farlow
Photochemical Generation And Intramolecular Chemistry Of 2-Hydroxy-2-Methylpropylidene, Robin Farlow
Honors Theses
2-(1a,9b-Dihydro-lH-cyclopropa[l]phenanthren-1-yl)-propan-2-ol was synthesized by two different but related synthetic routes and characterized by melting point, IR GC/MS, CHN, and NMR spectroscopy. Photolysis of the alcohol in benzene d-6 led to the formation of 2-butanone, 1-methylcyclopropanol, and 2,2-dimethyloxirane in a 26:10:1 ratio via 2-hydroxy-2methylpropylidene, a novel ?-hydroxycarbene. These products are a consequence of intramolecular insertions of the carbene into C-C, C-H, and O-H bonds. Molecular orbital calculations performed at the Becke-3LYP/6-31G(d) level indicate that the singlet form of this carbene is more thermodynamically stable than the triplet. Furthermore, the transition states to the three products from the singlet species were modeled …
Study Of The Effects Of Co2(G) On The Fe(Ii)-Luminol Chemiluminescence System: Application To Ultra-Trace Analysis Of Fe(Ii), Sara Beth Lovitz
Study Of The Effects Of Co2(G) On The Fe(Ii)-Luminol Chemiluminescence System: Application To Ultra-Trace Analysis Of Fe(Ii), Sara Beth Lovitz
Honors Theses
The Fe(II)-catalyzed oxidation of luminol has been a well-accepted chemiluminescence method for the trace and ultra-trace analysis of Fe(II) and Fe(III) in natural waters. Investigation into this chemiluminescence system has shown that COlg) is essential to Fe-catalyzed luminol chemiluminescence. In absence of CO2(g) there is no chemiluminescent signal. These reactions worked well in the past because CO2 is present in most laboratory H20 supplies. Intentional saturation of CO2 results in a 5-fold increase for this conventional system. We propose a mechanism for CO 2(g) enhancement that includes formation of a CO2-superoxide intermediate, which serves as the oxidant of luminol to …
A Study On The Effect Of Storage Time On Specific Gravity And Eggshell Quality, Brock Kendall Laborde
A Study On The Effect Of Storage Time On Specific Gravity And Eggshell Quality, Brock Kendall Laborde
Honors Theses
No abstract provided.
Constructing Regular Ramanujan Graphs Via Graph Extension, Sage Michelle Accardo
Constructing Regular Ramanujan Graphs Via Graph Extension, Sage Michelle Accardo
Honors Theses
No abstract provided.
Performance Of Genetic Algorithms For Data Classification, Matthew E. Stine
Performance Of Genetic Algorithms For Data Classification, Matthew E. Stine
Honors Theses
In today's world, the amount of raw data archived across multiple distinct domains is growing at an exponential rate. "Data Mining" is a continuously evolving family of processes by which individuals extract useful information from these data. Classification is one of these processes, and is the construction of varying types of descriptive models from labeled data objects, for the purpose of predicting the label of those objects with unknown labels. The construction of these modules is often adversely affected by the presence of incorrect values or outlier values within the data, a phenomenon known as noise. The original motivation of …
Isolation And Characterization Of Chromium- And Cobalt-Binding Peptides, Michael J. Jose
Isolation And Characterization Of Chromium- And Cobalt-Binding Peptides, Michael J. Jose
Honors Theses
Metal substitution has been proposed as an aid in the characterization of the structure of Low-Molecular-Weight Chromium-binding substance (LMWCr), which appears to be the biologically active chromium species. Preparations of bovine liver were diced and suspended in an isolation solution containing either a cobalt or a chromium salt. Peptide samples from these preparations were isolated by precipitation and centrifugation and purified by liquid chromatography. Several methods were used to analyze these samples, which may contain LMWCr or the cobalt-substituted form (LMWCo), in order to determine their purity, molecular weight (MW), and metal-to-peptide ratio. Methods used to determine MW included sodium …
Probing The Capabilities Of Copper Complexes With Nitrogen And Sulfur Containing Macrocyclic Ligands As Aziridination Catalysts, Jonathan Natkin
Probing The Capabilities Of Copper Complexes With Nitrogen And Sulfur Containing Macrocyclic Ligands As Aziridination Catalysts, Jonathan Natkin
Honors Theses
Aziridines are three-membered rings containing one nitrogen atom. They are useful as synthetic intermediates in many organic reactions. Much work has been devoted to synthesizing their analogs, cyclopropanes and epoxides, but little work has been done on the aziridination reaction. This study endeavored to probe the efficiencies of novel copper aziridination catalysts with N3 and S3 macrocyclic ligands compared to an NS2 analog for the reaction with the nitrene precursor (N-(paratosylsulfonyl) imino)phenyliodinane, PhINTs, and the olefin styrene. The nitrogen containing catalyst complex gave higher yields than the sulfur containing catalyst complex. Both ligands were found to decrease the yield of …
Synthetic Approach To Hexaoxa[6]Peristylanes. A Novel Ddq-Induced Oxidative Rearrangement, Douglas Arthur Otte
Synthetic Approach To Hexaoxa[6]Peristylanes. A Novel Ddq-Induced Oxidative Rearrangement, Douglas Arthur Otte
Honors Theses
The structural beauty and interesting bonding properties of polycyclic cage compounds have been a source of fascination to many chemists. In this work, progress toward the synthesis of large oxabowl systems, such as hexaoxa[6]peristylane and its derivative dipbenylhexaoxa[6)peristylane, is described. Thus, the adduct obtained from the cycloaddition of maleic anhydride and cyc!ooctatetraene is converted into key dicarbonyl intermediates. Subsequently, the ozonolysis of these intermediates is carried out in order to generate hexaoxa(6)peristylane as well as diphenylhexaoxa[6]peristylane. Molecular modeling studies, performed at the semi-empirical level, are also described.
Exploratory Chemistry In Route To Aromatic Natural Products, Nicholas P. Bizier
Exploratory Chemistry In Route To Aromatic Natural Products, Nicholas P. Bizier
Honors Theses
The focus of this research was the synthesis of two natural products, 1-methyl-s-(1,2,2-trimethy1cyclopentyl)-benzene (formally cuparene), and 3-(1,2dimethylcyclopenty1)-5-methylbenzene-l,2-diol (formally herbertene diol). Cuparene possesses anti-fungal and anti-arthritic properties. This molecule has been the target of a number of syntheses. Herbertene diol, a natural product itself, represents one retrosynthetic step back from mastigophorane; a compound isolated form the liverwort Mastigophora diaclolades. Mastigophorane has been shown to have neural network forming capabilities and has warranted complete synthetic efforts. Through the same chemistry involve in the formation of cuparene, we sought a route to herbertene diol in two steps. We report a successful route to …
Photochemical Degradation Of 2,4-D And Atrazine In Well-Defined Media, Asher D. Ghertner
Photochemical Degradation Of 2,4-D And Atrazine In Well-Defined Media, Asher D. Ghertner
Honors Theses
Atrazine and 2,4-D are common herbicides used for crop, lawn, and rangeland management. Photochemical degradation has been proposed as one safe and efficient remediation strategy for both 2,4-D and Atrazine. In the presence of iron(llI) and hydrogen peroxide these herbicides decay by both thermal and light induced oxidation. Past studies have focused primarily on sun light as an energy source. This work provides a mechanistic description of herbicide degradation incorporating intermediate degradation products produced in the dark and under well-defined light conditions.