Physical Sciences and Mathematics Commons^™

Pharmaceutical And Personal Care Products Concentrations In The Belgrade Lakes: A Possible Threat To Aquatic Ecosystems And Human Health, Serena Haver

Honors Theses

Pharmaceuticals and active ingredients from personal care products (PPCPs) include prescription and over-the-counter drugs, sunscreen, fragrances, and soaps. Recently researchers have detected PPCPs in surface waters, posing a threat to aquatic biota and human health. These compounds can enter the environment through dumping, direct excretion, or sewage effluent streams. We tested 14 water samples from East Pond, Great Pond, and Long Pond in Maine for the presence of 23 different PPCPs. Of those, we only detected significant levels of caffeine, 1,7-dimethylxanthine, and amphetamine all below 1µg/L. There were no significant differences between any of the three lakes for any of …

Phenanthrene...With A Twist!, Nicholas S. Kim

Honors Theses

The twisted and sterically hindered 4,5-dibromophenanthrene, was synthesized from 2,6-dibromoiodobenzene in a four-step pathway, or from 1,3-dibromobenzene in a three-step pathway. Then, 4,5-dibromophenanthrene was subjected to a Kumada coupling, leading to the synthesis of an even more twisted 4-bromo-5-tert-butylphenanthrene. Computational studies using density functional theory were performed to compare experimental and theoretical characteristics of these compounds, such as dihedral angles, optimized structures, and transition state energy barriers.

The purpose of these experiments is to fill gaps in chemical databases, synthesize more pronounced twists in normally planar phenanthrene molecules, and to ultimately synthesize 4,5-bis-tert-butylphenanthrene, which may have …

The Roles Of Introduced Eucalyptus In The Conservation And Expansion Of Ethiopian Orthodox Church Forests In The Northern Ethiopian Highlands, Janice Liang

Honors Theses

Species of the genus Eucalyptus (common name eucalyptus) are widely planted all across Ethiopia – including on large areas of land previously allocated to food production. In recent decades eucalyptus has also increasingly been planted on lands around and within “church forests,” sacred groves of old-aged Afromontane trees surrounding Ethiopian Orthodox Tewahido churches. These revered holy sites have long been recognized for their cultural values and also for their ecosystem services – including their potential to support species conservation and restoration, as church forests are some of the only remaining sanctuaries for many of Ethiopia’s indigenous and endemic plant and …

Using Genetic Algorithms To Evolve Artificial Neural Networks, William T. Kearney

Honors Theses

This paper demonstrates that neuroevolution is an effective method to determine an optimal neural network topology. I provide an overview of the NeuroEvolution of Augmenting Topologies (NEAT) algorithm, and describe how unique characteristics of this algorithm solve various problem inherent to neuroevolution (namely the competing conventions problem and the challenges associated with protecting topological innovation). Parallelization is shown to greatly speed up efficiency, further reinforcing neuroevolution as a potential alternative to traditional backpropagation. I also demonstrate that appropriate parameter selection is critical in order to efficiently converge to an optimal topology. Lastly, I produce an example solution to a medical …

Experimental And Computational Study Of Methylphenylvinylidene And Its Rearrangements, Xi Yang

Honors Theses

In this study, the synthesis and properties were explored of the compound methylphenylvinylidene (MPV), a vinylidene carbene with methyl and phenyl groups as substituents. A phenanthrene-based precursor, 1-(1-phenylethylidene)-1a,9b-dihydro-1H-cyclopropa[l]phenanthrene, was synthesized in three steps and was subjected to photolysis in C₆D₆ at ambient temperature. During photolysis, the MPV carbene rearranged into 1-phenylpropyne via a 1,2-phenyl shift, instead of 1,2-methyl shift, confirmed by photolysis of ¹³C-labeled precursor. This experimental result is consistent with computational results using the CCSD(T)/cc-pVTZ//B3LYP/6-31+G* method. The calculations suggest that the 1,2-phenyl shift in singlet carbene requires 3.8 kcal/mol to overcome …

Resonant Collisions Of Potassium Atoms, Philip Michael Adamson

Honors Theses

This thesis discusses an approach to excite potassium atoms to very highly excited states (Rydberg states), and then tune their energy levels to induce resonant collisions between atoms. Potassium gas is super-cooled to 1 mK and confined to a small volume in a magneto-optical trap. A 405 nm laser diode, electronically locked to a potassium vapor cell via Doppler free spectroscopy, excites these atoms from the 4s_1/2 state (ground state) to the 5p_3/2 state. A 978 nm laser then excites the 5p_3/2 to nd_3/2 or nd_5/2 transition, creating Rydberg atoms. Since there is no ground …

The Impact Of Endocrine-Disrupting Chemicals On Wildlife Conservation, Eda Reed

Honors Theses

Endocrine-disrupting chemicals (EDCs), such as those from plastics and pesticides, have been hypothesized to affect wildlife populations. According to the U.S. National Institute of Environmental Health Sciences, EDCs ‘are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife.’ A growing number of studies suggest wildlife are being exposed to EDCs, but how EDCs affect wildlife health and wildlife conservation is less well-understood. Through scientific literature analysis and a survey of wildlife conservationists and practitioners, this study aims to determine the current state of knowledge and data …

Real-Time Translation Of American Sign Language Using Wearable Technology, Jackson Taylor

Honors Theses

The goal of this work is to implement a real-time system using wearable technology for translating American Sign Language (ASL) gestures into audible form. This system could be used to facilitate conversations between individuals who do and do not communicate using ASL. We use as our source of input the Myo armband, an affordable commercially-available wearable technology equipped with on-board accelerometer, gyroscope, and electromyography sensors. We investigate the performance of two different classification algorithms in this context: linear discriminant analysis and k-Nearest Neighbors (k-NN) using various distance metrics. Using the k-NN classifier and windowed dynamic time …

Synthetic Flexibility Of A Bromopyrrole Ester Intermediate : Toward Novel Biologically Active Compounds, Scott Cameron Yeudall

Honors Theses

Compounds containing the pyrrole ring as a core structural motif continue to show significant biological activity, and both natural product derivatives and novel chemical scaffolds show potential for use as pharmaceuticals in treating a variety of cancers, infections, and inflammation. Given the widespread and important applications of compounds containing this motif, novel, rapid, and selective methods for the synthesis of multifunctional pyrroles is of some importance. Previous work in our group has utilized palladium-mediated Suzuki cross-coupling as a powerful tool for functionalizing activated bromopyrrole esters, generating structural analogues of bioactive natural products. We have also used a similar approach to …

An Examination Of The Cmb Large-Angle Suppression, Ellis Herman

Honors Theses

As shown by COBE­DMR and then by the Wilkinson Anisotropy Probe (WMAP), there exists an anomaly in the correlation function of the cosmic microwave background (CMB) radiation, namely that said correlation function is suppressed to zero on large angular scales. This observation conflicts with the prediction made by Lambda­CDM, the standard model of cosmology, indicating either necessary changes to the standard model or that our universe is a rare fluke within LCDM ­ such suppressions are seen in only about 0.3% of universes predicted by LCDM. To differentiate into which of these categories our universe falls, we have attempted to …

Cameron-Liebler Line Classes And Partial Difference Sets, Uthaipon Tantipongipat

Honors Theses

The work consists of three parts. The first is a study of Cameron-Liebler line classes which receive much attention recently. We studied a new construction of infinite family of Cameron-Liebler line classes presented in the paper by Tao Feng, Koji Momihara, and Qing Xiang (rst introduced in 2014), and summarized our attempts to generalize this construction to discover any new Cameron-Liebler line classes or partial difference sets (PDSs) resulting from the Cameron-Liebler line classes. The second is our approach to finding PDS in non-elementary abelian groups. Our attempt eventually led to the same general construction of PDS presented in John …

Structure-Function Relationships Affecting The Sensing Mechanism Of Monolayer-Protected Cluster Doped Xerogel Amperometric Glucose Biosensors, Luke T. Dipasquale

Honors Theses

The research conducted in the Leopold Bioanalytical and Nanomaterials Analytical Chemistry Lab prior to the summer of 2013 focused on the synthesis of a functional biosensor equipped with a nanoparticle network embedded in a xerogel film for the detection of glucose. Xerogel-based films featuring embedded glucose oxidase enzyme and doped with alkanethiolate-protected gold NPs, known as monolayer protected clusters (MPCs), exhibit significantly enhanced performance compared to analogous systems without NPs including higher sensitivity, faster response time, and extended linear/dynamic ranges.

The following presented research is a systematic study of the structure-function relationships critical to understanding the sensing mechanism of the …

Nonexistence Of Nonquadratic Kerdock Sets In Six Variables, John Clikeman

Honors Theses

Kerdock sets are maximally sized sets of boolean functions such that the sum of any two functions in the set is bent. This paper modifies the methodology of a paper by Phelps (2015) to the problem of finding Kerdock sets in six variables containing non-quadratic elements. Using a computer search, we demonstrate that no Kerdock sets exist containing non-quadratic six- variable bent functions, and that the largest bent set containing such functions has size 8.

Partitioning Groups With Difference Sets, Rebecca Funke

Honors Theses

This thesis explores the use of difference sets to partition algebraic groups. Difference sets are a tool belonging to both group theory and combinatorics that provide symmetric properties that can be map into over mathematical fields such as design theory or coding theory. In my work, I will be taking algebraic groups and partitioning them into a subgroup and multiple McFarland difference sets. This partitioning can then be mapped to an association scheme. This bridge between difference sets and association schemes have important contributions to coding theory.

A Study On The Characterization And Implementation Of Tools For Advanced Ligo, Hunter Gabbard

Honors Theses

The Laser Interferometer Gravitational Wave Observatory (LIGO) is aimed at directly detecting gravitational waves, small perturbations or ripples in the fabric of space-time. Because of their extreme sensitivity, the LIGO detectors are affected by many sources of non-astrophysical noise. In the first part of this thesis we test a pipeline designed for the identification of short-duration noise transients, called Omicron. We first inject simulated noise waveforms in engineering run data from the LIGO detector in Livingston, Louisiana and then determine Omicron efficiency by attempting to recover these injections. In the second part of this thesis, we present a novel method …

Study Of An Active-State Cb1 Receptor Model And Jwh Compound Interactions To Predict New Emerging Synthetic Cannabinoids, Kelsey Leigh Pettus

Honors Theses

In recent years, a new class of compounds, called synthetic cannabinoids, have made their appearance in the market as a substitute for illegal marijuana or its constituent natural cannabinoids. These compounds, which are active at the same G- protein coupled receptors (GPCRS) as cannabinoids, are continuing to gain popularity because of the same cannabinoid-like effects they create. Though two cannabinoid receptors have been identified in humans, known as CB1 and CB2, synthetic cannabinoid activity at the CB1 receptor has been the focus of much research regarding synthetic cannabinoid ligand binding. In this study, the structure of the CB1 receptor is …

The Synthesis Of Substituted Pentadentate Ligand Scaffolds And Their Future Application In Ruthenium-Catalyzed Water Oxidation, Manpreet Singh

Honors Theses

Rising global energy demands coupled with depleting natural resources have led to a strong emphasis on finding new sources of energy that are renewable and which limit the negative impact on the environment. One of the strongest candidates is utilizing solar energy to drive water oxidation to produce hydrogen as a fuel source. In order to do this, a better understanding of the mechanism involved in this process must be revealed. Homogenous molecular catalysts allow mechanistic studies and can be also used in Photoelectrochemical Cells (PECs) and other systems to produce chemical fuels. In this work, the new syntheses of …

Calculating Liquefaction Potential Of Northern Mississippi Using Shear Wave Data, Peshani Herath

Honors Theses

The potential for liquefaction can be determined using the Liquefaction Potential Index (LPI). The LPI takes into account the thickness of the liquefiable layers and the factors of safety with respect to depth. This study creates a hybrid method for determining the LPI for different locations in Northern Mississippi. It calculates an average CSR for the region using existing borehole information. The CRR is then calculated using shear wave velocity profile data from a MASW survey. The LPI obtained from this process is compared to LPI values calculated using CPT data and borehole shear wave data. Surface shear wave velocity …

Implementation Of An Enhanced System Of Motion Tracking For Virtual Reality Using 'Common Off-The-Shelf' Items, Sean M. O'Hara

Honors Theses

My project was tasked and guided by Dr. Adam Jones of the University of Mississippi's Computer Science Department to design and implement an improved system of infrared motion tracking for virtual reality. The enhancements allow Dr. Jones to use motion tracking for VR in ways that he previously could not, and these improvements include the ability to track multiple objects along with a foundation for expanding my project's use to work with a multiple camera setup for motion tracking. The hardware used in my project made use of Dr. Jones' supply of technology for development and research within the area …

Method Development Toward The Analysis Of The Functionalization Of Proteins, Victoria Calcote

Honors Theses

Calmodulin is a ubiquitous small intracellular protein that functions as a receptor for regulatory calcium signals and thus regulates a multitude of physiological processes in organisms as diverse as yeast, fruit flies, and mammals. Since its structure and function have been extensively studied, our goal is to create a calmodulin biomaterial, with the ultimate goal of in situ drug delivery or as a scaffold for stem cell growth and differentiation. We plan to create this biomaterial by using Click Chemistry, the rapid creation of new heteroatom bonds through a copper-catalyzed azide-alkyne cycloaddition. The bonds are created by treating calmodulin as …

Statistical Analysis Of Arsenic Concentrations In Subsurface Soils At The University Of Mississippi Field Station, David Thomas Webb

Honors Theses

The purpose of this investigation is to determine how arsenic concentration varies in soils with respect to soil structures, grain size, soil type, and depth. The investigation was conducted at the University of Mississippi Field Station (UMFS). The UMFS is located in Abbeville, MS and is roughly 700 acres in size. It includes ponds and former agricultural fields, and lies within an internally draining basin. Seven boreholes were drilled using a direct push geoprobe and sampled. The cores obtained from the borings were then cut at one foot intervals, producing a total of 90 soil samples. Each sample was observed …

Rhenium-Pyridyl-Nhcs For Photocatalytic Co2 Reduction, Emily Anne Sharpe

Honors Theses

The ability to transform CO2 into a useable fuel source would have a remarkably positive impact on the environment by taking the vast amounts of previous unusable CO2 from the atmosphere and reducing it to CO, which can then be turned into fuel. This project involves the synthesis and testing of air and water stable Re (I) pyridyl N- heterocyclic carbene (NHC) compounds for photocatalytic reduction of CO2 into CO using a simulated solar spectrum. Previous research in this area focused on the use of Re(bpy)CO3X, which quickly became the benchmark of homogeneous CO2 reduction photocatalysts. The Re (I) pyridyl …