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The Application Of Formyl Group Activation Of Brompyrrole Esters To A Formal Synthesis Of Lycogarubin C, Jon Patteson
The Application Of Formyl Group Activation Of Brompyrrole Esters To A Formal Synthesis Of Lycogarubin C, Jon Patteson
Honors Theses
Lycogarubln C is a member of an interesting family of marine natural products, which contains two indole groups appended to a pyrrole scaffold at the 3 and 4 positions. Such compounds are proposed to be biosynthetically related to the important antitumor agent, Staurosporine. Recent work in our lab involving the use of Suzuki cross-coupling reactions of an ortho activated bromoformylpyrrole ester has provided key intermediates for the synthesis of pyrrole natural products and pyrolle-based analogues.