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Full-Text Articles in Physical Sciences and Mathematics
The Application Of Formyl Group Activation Of Brompyrrole Esters To A Formal Synthesis Of Lycogarubin C, Jon Patteson
The Application Of Formyl Group Activation Of Brompyrrole Esters To A Formal Synthesis Of Lycogarubin C, Jon Patteson
Honors Theses
Lycogarubln C is a member of an interesting family of marine natural products, which contains two indole groups appended to a pyrrole scaffold at the 3 and 4 positions. Such compounds are proposed to be biosynthetically related to the important antitumor agent, Staurosporine. Recent work in our lab involving the use of Suzuki cross-coupling reactions of an ortho activated bromoformylpyrrole ester has provided key intermediates for the synthesis of pyrrole natural products and pyrolle-based analogues.
A Computational Investigation Of Halogen Bonding With Halomethanes And Their Group 14 Analogues, William Kretz
A Computational Investigation Of Halogen Bonding With Halomethanes And Their Group 14 Analogues, William Kretz
Honors Theses
It is known that halogen bonding is supported by so-called sigma holes on halides that interact with bases, but what are the limits of that interaction? How does the interaction depend on the group to which the halogen atom is bonded? To answer these questions, complexes of the form MH3X---Y (where M=C, Si, Ge, Sn, Pb; X= F, Cl, Br, I and Y are Lewis bases) were optimized and their energetics and relative stability were assessed. The Lewis bases range from NH3 to the more complicated pentafluroropyridine (F-py). Calculations were performed entirely at the MP2(full) level of theory, including frequency …