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Articles 1 - 11 of 11
Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Faculty of Science - Papers (Archive)
To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.
Inkjet And Extrusion Printing Of Conducting Poly(3,4-Ethylenedioxythiophene) Tracks On And Embedded In Biopolymer Materials, Charles A. Mire, Animesh Agrawal, Gordon G. Wallace, Paul Calvert, Marc In Het Panhuis
Inkjet And Extrusion Printing Of Conducting Poly(3,4-Ethylenedioxythiophene) Tracks On And Embedded In Biopolymer Materials, Charles A. Mire, Animesh Agrawal, Gordon G. Wallace, Paul Calvert, Marc In Het Panhuis
Faculty of Science - Papers (Archive)
Two printing methods, extrusion and inkjet, are used to deposit tracks of PEDOT/PSS conducting polymer onto biopolymer films with a view to prepare implantable tissue mimics containing electronic devices. Extruded tracks offer lower printing resolution, but better electrical characteristics compared to inkjet printed tracks. The biopolymer–ink interaction results in narrower printed tracks compared to those on glass. This affects the final conductivity, which is lower for printed tracks on biopolymer than for lines printed on glass, due to the part of the track lying below the surface. Extrusion printing is used to embed tracks into a biopolymer matrix, resulting in …
Synthesis Of Hyacinthacine B-3 And Purported Hyacinthacine B-7, Christopher W.G. Au, Robert J. Nash, Stephen G. Pyne
Synthesis Of Hyacinthacine B-3 And Purported Hyacinthacine B-7, Christopher W.G. Au, Robert J. Nash, Stephen G. Pyne
Faculty of Science - Papers (Archive)
The synthesis of hyacinthacines B-3 and B-7 has confirmed the structure of the former alkaloid and shown that the structure of the latter is incorrect.
Total Synthesis Of Uniflorine A, Casuarine, Australine, 3-Epi-Australine, And 3,7-Di-Epi-Australine From A Common Precursor, Thunwadee Ritthiwigrom, Anthony C. Willis, Stephen G. Pyne
Total Synthesis Of Uniflorine A, Casuarine, Australine, 3-Epi-Australine, And 3,7-Di-Epi-Australine From A Common Precursor, Thunwadee Ritthiwigrom, Anthony C. Willis, Stephen G. Pyne
Faculty of Science - Papers (Archive)
A flexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids Uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described.
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Faculty of Science - Papers (Archive)
Class 1 integrons play a role in the emergence of multi-resistant bacteria by facilitating the recruitment of gene cassettes encoding antibiotic resistance genes. 512 E. coli strains sourced from humans (n = 202), animals (n = 304) and the environment (n = 6) were screened for the presence of the intI1 gene. In 31/79 integron positive E. coli strains, the gene cassette regions could not be PCR amplified using standard primers. DNA sequence analysis of 6 serologically diverse strains revealed atypical integrons harboured the dfrA5 cassette gene and only 24 bp of the integron 3'-conserved segment (CS) remained, due to …
Fragmentation Pathways Of 2,3-Dimethyl-2,3-Dinitrobutane Cations In The Gas Phase, Martin Paine, Benjamin Kirk, Simon Ellis-Steinborner, Stephen J. Blanksby
Fragmentation Pathways Of 2,3-Dimethyl-2,3-Dinitrobutane Cations In The Gas Phase, Martin Paine, Benjamin Kirk, Simon Ellis-Steinborner, Stephen J. Blanksby
Faculty of Science - Papers (Archive)
2,3-Dimethyl-2,3-dinitrobutane (DMNB) is an explosive taggant added to plastic explosives during manufacture making them more susceptible to vapour-phase detection systems. In this study, the formation and detection of gas-phase [M+H](+), [M+Li](+), [M+NH4](+) and [M+Na](+) adducts of DMNB was achieved using electrospray ionisation on a triple quadrupole mass spectrometer. The [M+H](+) ion abundance was found to have a strong dependence on ion source temperature, decreasing markedly at source temperatures above 50 degrees C. In contrast, the [M+Na](+) ion demonstrated increasing ion abundance at source temperatures up to 105 degrees C. The relative susceptibility of DMNB adduct ions toward dissociation was investigated …
(-)-Epigallocatechin-3-Gallate (Egcg) Maintains K-Casein In Its Pre-Fibrillar State Without Redirecting Its Aggregation Pathway, Sean A. Hudson, Heath Ecroyd, Francis C. Dehle, Ian F. Musgrave, John Carver
(-)-Epigallocatechin-3-Gallate (Egcg) Maintains K-Casein In Its Pre-Fibrillar State Without Redirecting Its Aggregation Pathway, Sean A. Hudson, Heath Ecroyd, Francis C. Dehle, Ian F. Musgrave, John Carver
Faculty of Science - Papers (Archive)
The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer's, Parkinson's and Huntington's diseases, respectively. EGCG redirects the aggregation of these polypeptides to a disordered off-folding pathway that results in the formation of non-toxic amorphous aggregates. whether this anti-fibril activity is specific to these disease-related target proteins or ismore generic remains to be established. In addition, the mechanism by which EGCG exerts its effects, as with all anti-amyloidogenic polyphenols, remains unclear. To address these aspects, we have …
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Faculty of Science - Papers (Archive)
The Li+–(H2)n n = 1–3 complexes are investigated through infrared spectra recorded in the H–H stretch region (3980–4120 cm−1) and through ab initio calculations at the MP2∕aug-cc-pVQZ level. The rotationally resolved H–H stretch band of Li+–H2 is centered at 4053.4 cm−1 [a −108 cm−1 shift from the Q1(0) transition of H2]. The spectrum exhibits rotational substructure consistent with the complex possessing a T-shaped equilibrium geometry, with the Li+ ion attached to a slightly perturbed H2 molecule. Around 100 rovibrational transitions belonging to …
~3,850 Ma Tonalites In The Nuuk Region, Greenland: Geochemistry And Their Reworking Within An Eoarchaean Gneiss Complex, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Kenji Horie, Hiroshi Hidaka
~3,850 Ma Tonalites In The Nuuk Region, Greenland: Geochemistry And Their Reworking Within An Eoarchaean Gneiss Complex, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Kenji Horie, Hiroshi Hidaka
Faculty of Science - Papers (Archive)
The Eoarchaean (>3,600 Ma) Itsaq Gneiss Complex of southern West Greenland is dominated by polyphase orthogneisses with a complex Archaean tectonothermal history. Some of the orthogneisses have c. 3,850 Ma zircons, and they vary from rare single phase metatonalites to more common complexly banded migmatites. This is due to heterogeneous strain, in situ anatexis and granitic veining superimposed during younger tectonothermal events. In the single-phase tonalites with c. 3,850 Ma zircon, oscillatory-zoned prismatic zircon is all 3,850 Ma old, but shows patchy ancient loss of radiogenic Pb. SHRIMP spot analyses and laser ablation ICP-MS depth profiling show that thin …
Crystallization And Diffraction Data Of 1h-3-Hydroxy-4-Oxoquinoline 2,4-Dioxygenase: A Cofactor-Free Oxygenase Of The Alpha/Beta-Hydrolase Family, Ruhu Qi, Susanne Fetzner, Aaron J. Oakley
Crystallization And Diffraction Data Of 1h-3-Hydroxy-4-Oxoquinoline 2,4-Dioxygenase: A Cofactor-Free Oxygenase Of The Alpha/Beta-Hydrolase Family, Ruhu Qi, Susanne Fetzner, Aaron J. Oakley
Faculty of Science - Papers (Archive)
1H-3-Hydroxy-4-oxoquinoline 2,4-dioxygenase (QDO) from Pseudomonas putida 33/1 catalyses the oxygenolysis of 1H-3-hydroxy-4-oxoquinoline to form N-formylanthranilic acid and carbon monoxide without the aid of cofactors. Both N-terminally His6-tagged and native QDO were overexpressed in Escherichia coli and purified by conventional chromatographic procedures. Untagged QDO, but not His6-tagged QDO, was crystallized by the vapour-diffusion method, giving hexagonal bipyramid crystals belonging to space group P6(1)22. Selenomethionine-containing native QDO was prepared and crystallized under identical conditions. The unit-cell parameters were a = b = 90.1, c = 168.6 A, alpha = beta = 90, gamma = 120 degrees. Using synchrotron radiation, these crystals diffract …
Microcosm: A Lost Cost 3-D Wireless Sensor Test-Bed Within A Controllable Environment, David Marsh, Richard Tynan, Stephen T. Beirne, Roderick L. Shepherd, Gregory O'Hare, Dermot Diamond, Brian Corcoran
Microcosm: A Lost Cost 3-D Wireless Sensor Test-Bed Within A Controllable Environment, David Marsh, Richard Tynan, Stephen T. Beirne, Roderick L. Shepherd, Gregory O'Hare, Dermot Diamond, Brian Corcoran
Faculty of Science - Papers (Archive)
This paper describes the creation of Microcosm, a low cost wireless sensor network test-bed within a controlled environment to facilitate WSN experiments in three dimensions, with an emphasis on executing sensing-related experiments. The design of the sensing hardware, software, support tools and the experimental environment itself are given. Issues related to the design of this configuration are discussed, with the potential pitfalls and eventual solutions alike given. Finally, current and future uses for the test-bed are listed.