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Academic -- UNF -- Biology; Nocardiopsis sp; Marine Actinomycete; anti-cancer products; biosynthetic pathway
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Full-Text Articles in Physical Sciences and Mathematics
Characterization Of A Biosynthetic Pathway Yielding Anticancer Natural Products From A Marine Bacterium, Elle D. James
Characterization Of A Biosynthetic Pathway Yielding Anticancer Natural Products From A Marine Bacterium, Elle D. James
UNF Graduate Theses and Dissertations
Natural products are bioactive secondary metabolites produced by living organisms and are prevalently utilized as pharmaceutical drugs. Marine adapted organisms are a promising source of new natural products possessing unique chemical structures and biological activities. By studying the biosynthetic pathways employed by living organisms to produce natural products, insights into new strategies to generate molecules to combat disease and overcome drug resistance may be gained. This thesis study aimed to uncover the biosynthetic pathway employed by a marine actinomycete, Nocardiopsis sp. CMB-M0232, to catalyze the assembly of the nocardioazines. These molecules are a group of 2,5-diketopiperazine natural products that feature …