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Full-Text Articles in Physical Sciences and Mathematics
Behavioral Modulation Of Supramolecular Assemblies Via Covalent And Non-Covalent Interfacial Transformations, Ann Fernandez
Behavioral Modulation Of Supramolecular Assemblies Via Covalent And Non-Covalent Interfacial Transformations, Ann Fernandez
Doctoral Dissertations
There are several molecular level mechanisms at the origin of biological functions that serve as inspiration for the development of the “next generation” of materials that display adaptive and interactive properties. However, it will take time for synthetic materials to approach the level of complexity, robustness, and adaptability of biological systems. Although there are switchable platforms that respond via sensitized molecular components, there are currently no examples of materials that truly possess the type of autonomous behavior seen in biological systems. Even though these concepts are common in living organisms, their translation into a synthetic platform remains challenging to this …
Formulation And Characterization Of Lipogels As A Tunable Delivery Scaffold, Celia Homyak
Formulation And Characterization Of Lipogels As A Tunable Delivery Scaffold, Celia Homyak
Doctoral Dissertations
Nanomedicines within the clinic commonly utilize lipid-based scaffolds due to their aqueous assembly and non-covalent dual-guest loading capabilities. Nevertheless, poor stability in vivo and premature guest release remains a challenge with these systems. Polymeric nanomaterials are a popular alternative due to their good stability in vivo with controllable guest release. A caveat to polymeric scaffolds though, is the excess synthetic effort involved for non-covalent dual-drug encapsulation. Benefit lies in harnessing advantages of lipid and polymeric materials via lipid-polymer hybrid scaffold. Such materials have promise due to their dual-encapsulation and dual-stimuli-sensitive characteristics. The need to better understand these materials led us …