Physical Sciences and Mathematics Commons^™

Multi-Modal Medical Imaging Analysis With Modern Neural Networks, Gongbo Liang

Theses and Dissertations--Computer Science

Medical imaging is an important non-invasive tool for diagnostic and treatment purposes in medical practice. However, interpreting medical images is a time consuming and challenging task. Computer-aided diagnosis (CAD) tools have been used in clinical practice to assist medical practitioners in medical imaging analysis since the 1990s. Most of the current generation of CADs are built on conventional computer vision techniques, such as manually defined feature descriptors. Deep convolutional neural networks (CNNs) provide robust end-to-end methods that can automatically learn feature representations. CNNs are a promising building block of next-generation CADs. However, applying CNNs to medical imaging analysis tasks is …

“The Tale Of 3,000 Zircons”: An Investigation Of Grenville Sedimentation In Amazonia Using U/Pb Detrital Zircon Geochronology, Felicia R. Harris

Theses and Dissertations--Earth and Environmental Sciences

The continental collision between Laurentia and Amazonia that generated Rodinia and the Grenville Orogen is proposed to be one of the largest, hottest and longest-lived orogens in Earth history. Subsequent erosion and weathering led to a mountain range’s worth of sediment recycled into clastic systems across North America, otherwise known as the “Great Grenville Sedimentation Event”. The Sunsas orogeny in Amazonia is correlative to the Grenville in North America and is proposed to be the result of final Rodinian collision at 1200-1000 Ma. Despite the connection between the two ranges and the robust sedimentary record in North America, little work …

“Distance Learning” In The Ninth Century?: Micro-Cluster Analysis Of The Epistolary Network Of Alcuin After 796, William James Mattingly

Theses and Dissertations--History

Scholars of eighth- and ninth-century education have assumed that intellectuals did not write works of Scriptural interpretation until that intellectual had a firm foundation in the seven liberal arts.This ensured that anyone who embarked on work of Scriptural interpretation would have the required knowledge and methods to read and interpret Scripture correctly. The potential for theological error and the transmission of those errors was too great unless the interpreter had the requisite training. This dissertation employs computistical methods, specifically the techniques of social network mapping and cluster analysis, to study closely the correspondence of Alcuin, a late-eighth- and early-ninth-century scholar …

Testing Interpretations Of The Displacement Magnitude Of The Teton Fault And Uplift Of The Teton Range, Wyoming With Integrated Flexural-Kinematic And Thermal Modeling, Autumn Helfrich

Theses and Dissertations--Earth and Environmental Sciences

The Teton fault is a range-front normal fault in northwestern Wyoming. Previous estimates of the maximum displacement (D_max) on the Teton fault cover a wide range (2 - 11 km). Discrepancies also exist regarding the slip onset timing, which spans 2 - 13 Ma. To address these discrepancies, the exhumation history of the Teton Range is here investigated using forward flexural-kinematic (Move) and thermal-kinematic (Pecube) models that can be compared with previously reported apatite fission track (AFT) and apatite (U-Th)/He (AHe) ages from Mount Moran, which has been previously hypothesized to represent the …

Quantum Phases And Phase Transitions In Designer Spin Models, Nisheeta Desai

Theses and Dissertations--Physics and Astronomy

This work focuses on numerical studies of quantum spin systems. These simple models are known to exhibit a variety of phases, some of which have no classical counterpart. Phase transitions between them are driven by quantum fluctuations and the unconventional nature of some such transitions make them a fascinating avenue of study.

Quantum Monte Carlo (QMC) is an indispensable tool in the study of these phases and phase transitions in two and higher dimensions. Nevertheless, we are limited by our inability to simulate models that suffer from the infamous sign problem. While the case of S=1/2 has been studied …

Estimating Free-Flow Speed With Lidar And Overhead Imagery, Armin Hadzic

Theses and Dissertations--Computer Science

Understanding free-flow speed is fundamental to transportation engineering in order to improve traffic flow, control, and planning. The free-flow speed of a road segment is the average speed of automobiles unaffected by traffic congestion or delay. Collecting speed data across a state is both expensive and time consuming. Some approaches have been presented to estimate speed using geometric road features for certain types of roads in limited environments. However, estimating speed at state scale for varying landscapes, environments, and road qualities has been relegated to manual engineering and expensive sensor networks. This thesis proposes an automated approach for estimating free-flow …

Deep Neural Architectures For End-To-End Relation Extraction, Tung Tran

Theses and Dissertations--Computer Science

The rapid pace of scientific and technological advancements has led to a meteoric growth in knowledge, as evidenced by a sharp increase in the number of scholarly publications in recent years. PubMed, for example, archives more than 30 million biomedical articles across various domains and covers a wide range of topics including medicine, pharmacy, biology, and healthcare. Social media and digital journalism have similarly experienced their own accelerated growth in the age of big data. Hence, there is a compelling need for ways to organize and distill the vast, fragmented body of information (often unstructured in the form of natural …

A Modeling Approach To Understanding Glyphosate Transport In The Belize River Watershed, Barbara Anmei Astmann

Theses and Dissertations--Civil Engineering

Glyphosate is the most widely used herbicide worldwide and is often transported from application areas to surface water when solubilized in runoff or sorbed to eroded sediment. There is evidence that suggests both glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) may pose a risk to human health, as well as cause adverse effects in the environment. However, consistent monitoring data is still limited, especially in developing countries. Belize is a developing nation with agriculture being a major sector of its economy and is heavily reliant on glyphosate. The widespread use of glyphosate in Belize may be resulting in glyphosate …

Characterization Of Rare Earth Elements In The Illinois Basin Coals, Alireza Valian

Theses and Dissertations--Mining Engineering

The purpose of this study is to characterize the distribution and occurrence of rare earth elements (REEs) in the coal and coal-related material from the Illinois Basin. For characterizing the distribution of REEs, 17 core samples were investigated from various parts in the basin. Also, several individual samples from coal preparation plants and isolated geological occurrences were included in the study. In result, the average REE concentrations were calculated on a bed-to-bed basis, although the distribution of REEs in the coal beds was found laterally and vertically heterogeneous. A number of trends were found that describe the variations. Most importantly, …

Fault Identification On Electrical Transmission Lines Using Artificial Neural Networks, Christopher W. Asbery

Theses and Dissertations--Electrical and Computer Engineering

Transmission lines are designed to transport large amounts of electrical power from the point of generation to the point of consumption. Since transmission lines are built to span over long distances, they are frequently exposed to many different situations that can cause abnormal conditions known as electrical faults. Electrical faults, when isolated, can cripple the transmission system as power flows are directed around these faults therefore leading to other numerous potential issues such as thermal and voltage violations, customer interruptions, or cascading events. When faults occur, protection systems installed near the faulted transmission lines will isolate these faults from the …

Structural And Lexical Methods For Auditing Biomedical Terminologies, Rashmie Abeysinghe

Theses and Dissertations--Computer Science

Biomedical terminologies serve as knowledge sources for a wide variety of biomedical applications including information extraction and retrieval, data integration and management, and decision support. Quality issues of biomedical terminologies, if not addressed, could affect all downstream applications that use them as knowledge sources. Therefore, Terminology Quality Assurance (TQA) has become an integral part of the terminology management lifecycle. However, identification of potential quality issues is challenging due to the ever-growing size and complexity of biomedical terminologies. It is time-consuming and labor-intensive to manually audit them and hence, automated TQA methods are highly desirable. In this dissertation, systematic and scalable …

Temporal Data Extraction And Query System For Epilepsy Signal Analysis, Yan Huang

Theses and Dissertations--Computer Science

The 2016 Epilepsy Innovation Institute (Ei2) community survey reported that unpredictability is the most challenging aspect of seizure management. Effective and precise detection, prediction, and localization of epileptic seizures is a fundamental computational challenge. Utilizing epilepsy data from multiple epilepsy monitoring units can enhance the quantity and diversity of datasets, which can lead to more robust epilepsy data analysis tools. The contributions of this dissertation are two-fold. One is the implementation of a temporal query for epilepsy data; the other is the machine learning approach for seizure detection, seizure prediction, and seizure localization. The three key components of our temporal …

Tracing Source Contributions To Assess Spatial Patterns Of Erosion In A Mixed Land Use Environment: Otter Creek Catchment, Fort Knox, Kentucky, Cara Peterman

Theses and Dissertations--Earth and Environmental Sciences

There is an inherent difficulty in predicting source contributions of fine-grained fluvial sediment in mixed land-use watersheds. Over a 56-week period, the spatial and temporal variability in sediment-source contributions and water quality was monitored at three sites along Otter Creek in Hardin and Meade counties, Kentucky (USA). The 203-km² study area drains rural and agricultural lands and includes Fort Knox Army Post’s tracked-vehicle training areas. The main objectives for sediment source apportionment were to 1) identify and differentiate characteristics of civilian and military source soils to Otter Creek and 2) to apportion sediment at locations along Otter Creek to …

A Multi-Method Investigation Of The Modern Sedimentation And Late Holocene Paleolimnology Of June Lake (Mono County, Ca), And A Survey-Based Analysis Of Ninth Graders’ Attitudes Towards Geology, Eva Lyon

Theses and Dissertations--Earth and Environmental Sciences

Three distinct manuscripts comprise this dissertation. The first analyzes the modern sedimentary basin of June Lake, a small glacial lake in the eastern Sierra Nevada of California (USA) using a number of data sets, including bathymetry, surface sediment composition, and seismic stratigraphy. The seismic survey revealed sublacustrine morphological features that suggest the basin originated due to ice scour, as well as four acoustically distinct stratigraphic units that reflect the history of sedimentation following glacial scouring. Corroborating the seismic record, sediment cores from the youngest unit are composed of hemipelagically deposited, organic-rich, laminated diatomaceous oozes alternating with coarse tephra beds. The …

Identification Of The Causes And Extent Of Elevated Methane Concentrations In The Groundwater Of Eastern Kentucky, Cristopher Alvarez Villa

Theses and Dissertations--Earth and Environmental Sciences

Recent development of unconventional oil and gas (UOG) resources has prompted concerns about its potential impact on public health and the quality of water and air resources. Elevated dissolved methane concentrations (> 1 mg/L) have been associated with proximity to UOG development and stray gas, but also with natural microbial activity. Baseline gas data, local hydrogeology and geochemistry context can aid assessment of methane sources and interactions. Methane concentrations in eastern Kentucky groundwater are above the “immediate action” level in some private/domestic water wells, show wide variations over small distances, and have been hypothesized to have different relationships to mining. …

Isotopic And Geochemical Tracers Of Groundwater Flow In The Shivwits Plateau, Grand Canyon National Park, Jonathan W. Wilson

Theses and Dissertations--Earth and Environmental Sciences

As the impacts of global climate change on water resources continue to become more apparent, proper understanding and management of groundwater resources will be needed as supplies become more strained. Traditional methods of characterizing groundwater systems are time-intensive, costly, and can be difficult to complete in remote areas. Using ambient geochemical tracers from discrete sampling could aid in characterizing spring systems through determining flow paths, recharge areas, and carbon cycling. However, using discrete seasonal samples to understand the hydrogeology of complex, mixed-lithology aquifers has not been extensively examined. Here we explore using δ¹³C of dissolved organic carbon (DOC), …

Effects Of Hole Transporting Layers And Surface Ligands On Interface Energetics And Photovoltaic Performance Of Methylammonium Lead Iodide Perovskites, So Min Park

Theses and Dissertations--Chemical and Materials Engineering

Organic metal halide perovskites are promising materials for various optoelectronic device applications such as light emitting diodes (LED) and photovoltaic (PV) cells. Perovskite solar cells (PSCs) have shown dramatic increases in power conversion efficiency over the previous ten years, far exceeding the rate of improvement of all other PV technologies. PSCs have attracted significant attention due to their strong absorbance throughout the visible region, high charge carrier mobilities, color tunability, and ability to make ultralight weight devices. However, organic metal halide perovskites still face several challenges. For example, their environmental stability issue must be overcome to enable widespread commercialization. Meeting …

Biogeomorphology Of Bedrock Fluvial Systems: Example From Shawnee Run, Kentucky, Usa, Tasnuba Jerin

Theses and Dissertations--Geography

The dynamic interactions between fluvial processes and vegetation vary in different environments and are uncertain in bedrock settings. Bedrock streams are much less studied than alluvial in all aspects, and in many respects act in qualitatively different ways. This research seeks to fill this lacuna by studying bedrock streams from a biogeomorphic perspective. The first part of this research aims to identify the impacts of woody vegetation that may be common to fluvial systems and rocky hillslopes in general, or that may be unique to bedrock channels. A review of the existing literature on biogeomorphology — mostly fluvial and rocky …

Nonparametric Analysis Of Clustered And Multivariate Data, Yue Cui

Theses and Dissertations--Statistics

In this dissertation, we investigate three distinct but interrelated problems for nonparametric analysis of clustered data and multivariate data in pre-post factorial design.

In the first project, we propose a nonparametric approach for one-sample clustered data in pre-post intervention design. In particular, we consider the situation where for some clusters all members are only observed at either pre or post intervention but not both. This type of clustered data is referred to us as partially complete clustered data. Unlike most of its parametric counterparts, we do not assume specific models for data distributions, intra-cluster dependence structure or variability, in effect …

Development Of A Robust Treatment Delivery Framework For Stereotactic Body Radiotherapy (Sbrt) Of Synchronous Multiple Lung Lesions, Lana Catherine Critchfield

Theses and Dissertations--Radiation Medicine

Stereotactic body radiation therapy (SBRT) of lung tumors uses high doses of radiation to deliver high biological effective doses (BED) in very few fractions (1-5). With the use of highly conformal fields to cover the tumor without depositing large doses to non-cancerous structures, this technique has proven time and again to be successful at achieving high local control. However, frequently patients receiving SBRT are elderly with multiple medical comorbidities who may not tolerate long treatment times. Furthermore, many patients present with oligometastatic or multiple primary lung tumors. The success of SBRT on oligometastatic lung disease relies on physician experience with …

Estimation Of The Treatment Effect With Bayesian Adjustment For Covariates, Li Xu

Theses and Dissertations--Statistics

The Bayesian adjustment for confounding (BAC) is a Bayesian model averaging method to select and adjust for confounding factors when evaluating the average causal effect of an exposure on a certain outcome. We extend the BAC method to time-to-event outcomes. Specifically, the posterior distribution of the exposure effect on a time-to-event outcome is calculated as a weighted average of posterior distributions from a number of candidate proportional hazards models, weighing each model by its ability to adjust for confounding factors. The Bayesian Information Criterion based on the partial likelihood is used to compare different models and approximate the Bayes factor. …

Large N Fields And Holography, Animik Ghosh

Theses and Dissertations--Physics and Astronomy

We study (nearly) AdS/CFT holography within the context of the Sachdev-Ye- Kitaev (SYK) model. We present a systematic procedure to extract the dynamics of the low energy Schwarzian mode in SYK type models with a single energy scale J and emergent reparametrization symmetry in the infrared within the framework of perturbation theory. We develop a systematic approach using Feynman diagrams in bilocal theory to obtain a formal expression for the enhanced and O(1) corrections to the bilocal propagator and apply this general technique to large q SYK. We show that the Schwarzian theory describes a sector of a general class …

The Pion Form Factor And Momentum And Angular Momentum Fractions Of The Proton In Lattice Qcd, Gen Wang

Theses and Dissertations--Physics and Astronomy

Lattice Quantum Chromodynamics (QCD) provides a way to have a precise calculation and a new way of understanding the hadrons from first principles. From this perspective, this dissertation focuses first on a precise calculation of the pion form factor using overlap fermions on six ensembles of 2+1-flavor domain-wall configurations generated by the RBC/UKQCD collaboration with pion masses varying from 137 to 339 MeV. Taking advantage of the fast Fourier transform, low-mode substitution (LMS) and the multi-mass algorithm to access many combinations of source and sink momenta, we have done a simulation with various valence quark masses and with a range …

Study Of Cell Charging Effects For The Neutron Electric Dipole Moment Experiment At Oak Ridge National Laboratory, Mark Broering

Theses and Dissertations--Physics and Astronomy

The neutron electric dipole moment (nEDM) collaboration at the Spallation Neutron Source plans to use ultra-cold neutrons in superfluid helium to improve the nEDM limit by about two orders of magnitude. In this apparatus, neutrons are stored in poly(methyl methacrylate), PMMA, cells located in a strong, stable electric field. This electric field is produced by high voltage electrodes located outside of the neutron cells. Several sources generate charged particles inside the neutron cells. The electric field pulls these charges farther apart, attracting each to the oppositely charged electrode. As the charges build up on the cells walls, they create an …

Electrical And Magnetic Transport Properties Of Periodic And Aperiodic Artificial Spin Ice Systems, Justin Woods

Theses and Dissertations--Physics and Astronomy

In recent years, the topic of magnetic frustration in systems and the effect that frustration can have on system dynamics has been a rich environment for study. One such system that lends itself directly to this study are systems of single domain ferromagnetic bars in two dimensions. These ferromagnetic bars can be fabricated from a thin film using current lithography techniques. The bars are fabricated in such a way that their shape anisotropy dictates the magnetization of the bar will be a single domain, Ising-like magnetic moment. These single domain magnetic bars scan be arranged to introduce frustration of their …

Effects Of Aperiodicity And Frustration On The Magnetic Properties Of Artificial Quasicrystals, Barry Farmer

Theses and Dissertations--Physics and Astronomy

Quasicrystals have been shown to exhibit physical properties that are dramatically different from their periodic counterparts. A limited number of magnetic quasicrystals have been fabricated and measured, and they do not exhibit long-range magnetic order, which is in direct conflict with simulations that indicate such a state should be accessible. This dissertation adopts a metamaterials approach in which artificial quasicrystals are fabricated and studied with the specific goal of identifying how aperiodicity affects magnetic long-range order. Electron beam lithography techniques were used to pattern magnetic thin films into two types of aperiodic tilings, the Penrose P2, and Ammann-Beenker tilings. SQUID …

Carbon Oxidation At The Atomic Level: A Computational Study On Oxidative Graphene Etching And Pitting Of Graphitic Carbon Surfaces, Simon Schmitt

Theses and Dissertations--Mechanical Engineering

In order to understand the oxidation of solid carbon materials by oxygen-containing gases, carbon oxidation has to be studied on the atomic level where the surface reactions occur. Graphene and graphite are etched by oxygen to form characteristic pits that are scattered across the material surface, and pitting in turn leads to microstructural changes that determine the macroscopic oxidation behavior. While this is a well-documented phenomenon, it is heretofore poorly understood due to the notorious difficulty of experiments and a lack of comprehensive computational studies. The main objective of the present work is the development of a computational framework from …

Sensitivity Of Electron-Proton Coincidence Asymmetries In Neutron Beta-Decay To Scalar And Tensor Interactions, Subash C. Nepal

Theses and Dissertations--Physics and Astronomy

We study the combined sensitivity of measurements of electron-proton coincidence asymmetries in polarized neutron beta-decay together with a measurement of the electron energy spectrum in unpolarized neutron beta-decay to beyond Standard Model (BSM) scalar and tensor interactions, via the appearance of such BSM physics in the Fierz interference terms b and b_v. Whereas measurements of the electron energy spectrum directly probe b, both the proton and neutrino asymmetries for which experimental results exist are not sensitive to b_v, but effectively to b - b_v. This results in reduced sensitivity to BSM scalar and …

The Impact Of Ryegrass On A Fragipan Soil, Keegan Patrick Smith

Theses and Dissertations--Plant and Soil Sciences

Fragipans are soil horizons which negatively impact row crop yields due to their cemented nature. Annual ryegrass has been proposed as a cover crop to help remediate these dense horizons. The objectives of this study were to (1) evaluate potential ryegrass root exudates and their ability to solubilize proposed fragipan cementing agents, aluminum (Al), iron (Fe), and silica (Si) in stirred-batch reactor studies; and (2) evaluate annual ryegrass’ ability to remediate the fragipan through an 8-week greenhouse growth study using non-destructive, mini-rhizon samplers installed on soil cores for in situ pore water sampling, and non-invasive soil porosity calculations using X-ray …

Assessing The Climate Water Balance Model’S Ability To Predict Soil Moisture Variability And Species Distribution Of A Forested Watershed In The Northern Cumberland Plateau, Katherine J. Love

Theses and Dissertations--Forestry and Natural Resources

Spatial patterns of moisture and tree species have been studied using environmental gradients, often represented by terrain attributes in GIS. With climate change, GIS terrain variables, which are static as long as the elevation remains unchanged, will not reflect alterations in temperature, water cycle, and atmospheric conditions. In this thesis, the commonly used terrain variables and climate water balance variables were evaluated and compared for their ability to explain soil moisture and tree species distributions in a forested watershed in the Northern Cumberland Plateau. The results suggest that GIS terrain variables generally perform better than climate water balance variables, however, …