Physical Sciences and Mathematics Commons^™

Control Of Electrochemical And Ferryloxy Formation Kinetics Of Cyt P450s In Polyion Films By Heme Iron Spin State And Secondary Structure, Sadagopan Krishnan, Amila Abeykoon, John B. Schenkman, James F. Rusling

UCHC Articles - Research

Voltammetry of cytochrome P450 (cyt P450) enzymes in ultrathin films with polyions was related for the first time to electronic and secondary structure. Heterogeneous electron transfer (hET) rate constants for reduction of the cyt P450s depended on heme iron spin state, with low spin cyt P450cam giving a value 40-fold larger than high spin human cyt P450 1A2, with mixed spin human P450 cyt 2E1 at an intermediate value. Asymmetric reduction–oxidation peak separations with increasing scan rates were explained by simulations featuring faster oxidation than reduction. Results are consistent with a square scheme in which oxidized and reduced forms of …

Hierarchical Subject Inter-Relations In Physical Chemistry, Carl W. David

Chemistry Education Materials

Students mystified by the progression of topics in Physical Chemistry may gain insight into their path through the material if acquainted with the diagrams presented and discussed herein.

Constructed Response Answers In A Multiple-Choice Universe, Carl W. David

Chemistry Education Materials

A scheme is introduced which allows computer readable multiple choice forms used in traditional examinations to be employed for constructed response items.

Predator-Induced Plasticity In Spotted Salamanders (Ambystoma Maculatum), Laurel A. Dwyer

Honors Scholar Theses

The ability to respond plastically to the environment has allowed amphibians to evolve adaptive responses to spatial and temporal variation in predation threat. However, animals exposed to predators may also show costs of plasticity or tradeoffs. This study examines predator-induced plasticity in larval development, behavior, and metamorphosis in the spotted salamander, Ambystoma maculatum. Salamanders were raised in two treatments: with predator cues (a fish predator, genus Lepomis, on the other side of a divided tank), or without predator cues. During the larval stage the predator treatment group experienced higher mortality rates than the no-predator treatment group. Behavioral trials revealed that …

Fort Richardson Ordnance Detonations And The Harbor Porpoise: A Case Study In Marine Mammal Bioacoustics, Heather Heenehan

Honors Scholar Theses

Hearing is extremely important for cetaceans because it is their “principal sense” (Weilgart, 2007) thus the harbor porpoise and other marine animals are highly dependent on sound for survival. This is why we should care about the impact of noise on animals like the harbor porpoise. Since sound travels so well in water, an explosion, sonar, boat noise, etc. can affect a very large area and thus many different species of marine mammals. Although military actions such as low frequency sonar have made recent news, noise has been affecting cetaceans, especially beaked whales, since at least 1991 (Weilgart, 2007).

This …

Alternative Task Bar: A Usability Study, Jordan Cote

Honors Scholar Theses

An alternate approach to the task bar is proposed, one which makes use of modern computers' graphical abilities. This was accomplished with OpenGL, which is typically used in 3D scene generation. The application was integrated into the Desktop Environment in a novel way, in order to produce an arbitrary shaped window. The application was presented to survey participants, who were asked questions to reveal the feasibility of this type of task bar. Responses were positive, which encourages further development.

Visualizing The Simulation Of 3-D Underwater Sensor Networks, Matthew T. Tran

Honors Scholar Theses

The majority of sensor network research deals with land-based networks, which are essentially two-dimensional, and thus the majority of simulation and animation tools also only handle such networks. Underwater sensor networks on the other hand, are essentially 3D networks because the depth at which a sensor node is located needs to be considered as well. Due to that additional dimension, specialized tools need to be used when conducting simulations for experimentation.

The School of Engineering’s Underwater Sensor Network (UWSN) lab is conducting research on underwater sensor networks and requires simulation tools for 3D networks. The lab has extended NS-2, a …

Methyl Septanoside Hydrolysis As A Measure Of Carbohydrate Ring Flexibility: Substrate Synthesis And Kinetics Analysis, Shawn Michael Miller

Honors Scholar Theses

A number of seven-membered ring systems have been found to have promising enzyme inhibiting properties. The common explanation for their efficacy is the apparent improved flexibility that the ring-system has over smaller rings. In an attempt to probe the validity of this hypothesis, unnatural seven-membered ring carbohydrates have been generated and subjected to kinetics analysis using hydrolysis. In particular, methyl α- and β-D-glycero-D-guloseptanoside were subjected to acid-catalyzed hydrolysis and monitored via HNMR experiments. The rate constants of the reactions were determined and compared to the hydrolysis rate constants of comparable pyranose carbohydrates and found to be significantly faster, indicating an …

Retention Of Polarization Signatures In Shg Microscopy Of Scattering Tissues Through Optical Clearing, Oleg Nadiarnykh, Paul J. Campagnola

UCHC Articles - Research

Polarization responses in Second Harmonic Generation (SHG) imaging microscopy are a valuable method to quantify aspects of tissue structure, and may be a means to differentiate normal and diseased tissues. Due to multiple scattering, the polarization data is lost in turbid tissues. Here we investigate if this information can be retained through the use of optical clearing which greatly reduces the scattering coefficient and increases the corresponding mean free path. To this end, we have measured the SHG intensity as a function of laser polarization and the SHG signal anisotropy in murine tendon and striated muscle over a depth range …

Guessing Harmonic Oscillator Wavefunctions Using Maple, Carl W. David

Chemistry Education Materials

The guessing of eigenfunctions is not trivial at higher quantum numbers, no matter what the system being considered. Instead of guessing, one can employ a symbolic calculus progam (Maple in this case) to aid in the reasoning process.

The Driven Harmonic Oscillator In Chemistry, Carl W. David

Chemistry Education Materials

The molecular dynamical simulation of the normal vibrational mode of water which involves H-O-H angle deformation, when driven by an external force, can be used to see how a driven harmonic oscillator, classically, is associated with the infra-red spectrum of water (and the absorption for this particular normal mode).

Using The Morse Potential To Understand Reaction Coördinates Using Maple, Carl W. David

Chemistry Education Materials

The interactions employed in the “linear” reaction A(g)+BC(g) -> AB(g) + C(g) in a “one dimensional world” can be used to illustrate the “reaction coördinate”, using Maple, in a manner which allows students to inspect potential energy surfaces, make contour maps of those surfaces, and conceptually construct the “reaction coördinate” by tracing the local minimum path on the surface created.“one dimensional world” can be used to illustrate the “reaction coördinate”, using Maple, in a manner which allows students to inspect potential energy surfaces, make contour maps of those surfaces, and conceptually construct the “reaction coördinate” by tracing the local minimum …

Frobenius Solution For Legendre's Equation, Rodrigue's Formula And Normalization, Carl W. David

Chemistry Education Materials

The Frobenius solution to Legendre/s equation is developed in detail as is Rodrigue's formula, which is employed to normalize Legendre polynomials.

1s_A 1s_B Overlap Integrals, Analytic And Maple Approches, Carl W. David

Chemistry Education Materials

The calculation of overlap between adjacent orbitals (not on the same center) requires a slight facility with calculus which is quite instructive. That calculation is presented here.

Rationale For Studying Physical Chemistry, Carl W. David

Chemistry Education Materials

The various rationales for studying physical chemistry, and specifically the theoretical component thereof are presented in what is hoped in a coherent package.

The Harmonic Oscillator's Frobenius Solution, Carl W. David

Chemistry Education Materials

The Frobenius solution to the differential equations associated with the harmonic oscillator (QM) is carried out in detail.

The Hartree-Fock Method Applied To Helium's Electrons, Carl W. David

Chemistry Education Materials

The difficulties of applying the Hartree-Fock method to many body problems is illustrated by treating Helium's electrons up to the point where tractability vanishes. Second, the problem of applying Hartree-Fock methods to the helium atom's electrons, when they are constrained to remain on a sphere, is revisited. The 6-dimensional total energy operator is reduced to a 2-dimensional one, and the application of that 2-dimensional operator in the Hartree-Fock mode is discussed.

Multiple-Choice Testing In Science And Technology Courses, Carl W. David

Chemistry Education Materials

Wide spread and continuing use of multiple-choice testing in technical subjects is leading to a mindset amongst students which is antithetical with actual use of intellect.

L'Hopital's Rule In Chemistry: Irreversible Morphing Into Reversible Isothermal Expansions, Carl W. David

Chemistry Education Materials

L'Hopital's Rule is discussed in the cvase of an irreversible isothermal expansion.

Mo Visualization Of Pi Orbitals, Carl W. David

Chemistry Education Materials

In the spirit of trying to convert people to understanding atomic orbitals centered elsewhere than the origin, we continue the discussion of visualizing molecular orbitals, so called LCAO-MO, using various plotting tricks in Maple.

A Review Of Helium Hamiltonians, Carl W. David

Chemistry Education Materials

Helium Hamiltonian transformations are discussed in extreme detail.

Lee O Case's "Elements Of The Phase Rule", Introduction And Explanation, Carl W. David

Chemistry Education Materials

This out of print 1939 manuscript, updated, is added to the literature with slight additions

The Runge0lenz Vector (Continued), Carl W. David

Chemistry Education Materials

We continue our discussion of the Runge-Lenz vector in a quantum mechanical context. The traditional form of the Runge-Lenz vector is obtained, and the commutation relations between the Runge-Lenz vector, the Hamiltonian, and the Angular Momentum are obtained using Maple.

Lee O Case's "Elements Of The Phase Rule", Chapter 2, Carl W. David

Chemistry Education Materials

The second chapter of the Case text on the phase rule, this time dealing with two component systems, added to by the author, is presented here.

Carnot Cycles: Traditional And Stefan Boltzmann, And The First Planck Argument, Carl W. David

Chemistry Education Materials

The Stefan Boltzmann equation is obtained using a non-traditional Carnot Engine. In addition, the original Planck argument for radiation density is given.

Triatomic Molecular Orbitals, Carl W. David

Chemistry Education Materials

If elementary Quantum Chemistry stops at diatomic molecules, some students may be left with false impressions concerning how one builds polyatomic molecule's LCAO-MOs. This reading discusses building such molecular orbitals from atomic orbitals centered at different spatial coordinates.

Continued Fraction Solutions To Hermite's, Legendre's And Laguerre's Differential Equation, Carl W. David

Chemistry Education Materials

The continued fraction method for solving differential equations is illustrated using three famous differential equations used in quantum chemistry.

More Than You Ever Cared To Know About Solution Thermodynamics, Carl W. David

Chemistry Education Materials

These readings are a compendium of earlier works put together and corrected for errors. The subject is solution thermodynamics, based on the one dimensional binary solution as "extended" to three dimensions.

Lee O. Case's "Elements Of The Phase Rule", Chapter 1, One Component Systems, Carl W. David

Chemistry Education Materials

One component systems are treated from the point of view of the Gibbs' phase rule.

Lee O Case's "Elements Of The Phase Rule", Chapter 3, Carl W. David

Chemistry Education Materials

This is the last (third) chapter of the phase rule text, again altered by the author, addressing 3 and 4 compnent systems.