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Agar Gel; Electrophoretic Mobility Shift Assay; Glutathione; Molecular Structure; Oxidation-Reduction; Plasmids; Platinum; Prodrugs; Reducing Agents
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Full-Text Articles in Physical Sciences and Mathematics
Pt (Iv) Complexes As Prodrugs For Cisplatin, Yi Shi, Shu-An Liu, Deborah J. Kerwood, Jerry Goodisman, James C. Dabrowiak
Pt (Iv) Complexes As Prodrugs For Cisplatin, Yi Shi, Shu-An Liu, Deborah J. Kerwood, Jerry Goodisman, James C. Dabrowiak
Chemistry - All Scholarship
The antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxoplatin, c,t,c-[PtCl 2(OH) 2(NH 3) 2], 3, and a carboxylate-modified analog, c,t,c-[PtCl 2(OH)(O 2CCH 2CH 2CO 2H)(NH 3) 2], 4, by ascorbic acid (AsA) or glutathione (GSH). Since carbonate plays a significant role in the speciation of platinum complexes in solution, we …