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Full-Text Articles in Physical Sciences and Mathematics
On The Development Of Analytical Methodologies To Interrogate The Lipid Dynamics And Phase Transition Resulting From The Reduction Of Stimuli-Responsive Vesicles, James Edward Winter
On The Development Of Analytical Methodologies To Interrogate The Lipid Dynamics And Phase Transition Resulting From The Reduction Of Stimuli-Responsive Vesicles, James Edward Winter
LSU Doctoral Dissertations
The potential is great for liposome drug delivery systems that provide specific contents release at diseased tissue sites upon activation by upregulated enzymes; however, this potential will only come to fruition with mechanistic knowledge of the contents release process. NAD(P)H:quinone oxidoreductase type 1 (NQO1) is a target for reductively-responsive liposomes, as it is an enzyme upregulated in numerous cancer tissues and is capable of reducing quinone propionic acid (QPA) trigger groups to hydroquinones that self-cleave from dioleolylphosphatidylethanolamine (DOPE) liposome surfaces, thereby initiating contents release. This research targets the development of analytical methodologies to observe and characterize the dynamics and resulting …