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Full-Text Articles in Physical Sciences and Mathematics
Spectroscopic Analysis Of Therapeutic Drugs., Laura Perdisatt, Christine O'Connor, Samar Moqadasi, Luke O'Neill
Spectroscopic Analysis Of Therapeutic Drugs., Laura Perdisatt, Christine O'Connor, Samar Moqadasi, Luke O'Neill
Conference Papers
The aim of this project was to investigate the photochemistry of three new Ruthenium (II) complexes as possible therapeutics and their associated ligands. The objectives were to use the following spectroscopic techniques: Absorption, Emission and Raman spectroscopy. Luminescent lifetime measurements were obtained by laser studies (Nd:YAG laser and Time coupled single photon counting (TCSPC) ).
Synthesis And Spectroscopic Analysis Of Therapeutic Ru(Ii) Complexes, Samar Moqadasi, Laura Perdisatt, Christine O'Connor, Luke O'Neill
Synthesis And Spectroscopic Analysis Of Therapeutic Ru(Ii) Complexes, Samar Moqadasi, Laura Perdisatt, Christine O'Connor, Luke O'Neill
Conference Papers
The aim of this study is to synthesise and characterise new ligands based on a 1,10-Phenanthroline-5,6-dione backbone and their respective Ru(II) complexes; Ru(bpy)2mfmp, Ru(bpy)2fmp and Ru(bpy)2NO2-mp as shown in figure 1.The synthesis of the ligands will be discussed and a variety of Ru(II) complexes. A brief insight of the electronic and NMR spectroscopy will be presented along with preliminary photochemical results such as extinction coefficients, quantum yields and luminescence lifetimes. Ruthenium complexes have well established synthetic and photochemical properties.1The objective of this work is to synthesise Ru(II) complexes for the applications of potential therapeutics. In order to establish their uses …
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Conference Papers
The photostability studies of Folic acid and Menadione Sodium Bisulfite, also known as vitamin K3, were carried out in their aqueous solutions at room temperature. Solutions of Folic acid ( 4.8 x 10-5 M) and Menadione Sodium Bisulfite (4.0 x 10-4 M) were exposed to ultraviolet radiation at a wavelength of 365 nm. During exposure absorbance of both solutions was measured using a Perkin Elmer Lamda 900 UV/VIS/NIR Spectrometer. During the stability tests it was noted that addition of β Cyclodextrin (1:1 ratio) to aqueous solutions containing the vitamin slowed down the photodegradation process. The unique shape of Cyclodextrins allows …
Metallopharmaceuticals As Photoactivatable Anticancer Drugs, Samar Moqadasi, Christine O'Connor, Denis O'Shea, Michael Devereux
Metallopharmaceuticals As Photoactivatable Anticancer Drugs, Samar Moqadasi, Christine O'Connor, Denis O'Shea, Michael Devereux
Conference Papers
Target-based research (treating infected site only), directed towards the design and mechanism of action of metal-based anticancer complexes is expanding rapidly due to the selectivity and activity of such novel therapeutics. The photo activation of Ruthenium (II) complexes as therapeutic drugs has recently escalated as the complexes are suitable for photoactivation due to their well published photochemical and photophysical properties which in turn is the basis of photodynamic approaches to therapy.1-5 The aim of this study is to synthesise a series of metallo-complexes of which will be tested on tumour and non-tumour cell lines in the Radiation & Environmental Science …