Physical Sciences and Mathematics Commons^™

The Design, Synthesis, And Investigation Into Small Molecule Modulators Of The Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (Ship), Shea Thomas Meyer

Dissertations - ALL

The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 as a key secondary messenger in the transmission of signals from outside the cell to the nucleus. The SRC Homology 2 containing Inositol 5’-Phosphatase (SHIP) also plays a key role in the PI3K pathway, mediating hydrolysis of the inositol phospholipid PI(3,4,5)P3 to PI(3,4)P2. Early testing has shown modulation of SHIP activity through the use of small molecule modulators …

Trichloroacetimidates As Outstanding Electrophiles For The Carbon-Nitrogen, Carbon-Oxygen And Carbon-Carbon Bonds Formation And Synthetic Studies Of Protein Phosphatase-5 (Pp5) Small Molecule Inhibitors, Nilamber Mate

Dissertations - ALL

Trichloroacetimidates have been previously used for glycosidic bond formation in carbohydrate chemistry and in Friedel-Craft reactions. Traditionally, trichloroacetimidates had be synthesized using an alcohol and strongly basic conditions, but in recent years milder preparation methods have been reported. Given the ease of preparation of these versatile reagents, their chemistry has been explored intensely in recent years. While few reported methods suggest they can react under promoter free conditions, activation by Lewis or Brønsted acid leads to a formation of a carbocation from benzylic trichloroacetimidates. Work described herein makes use of these convenient carbocation precursors for new reactions.Isatin is an ambidentate …

A Closer Look At The Synthesis And Characterization Of Alkaline Earth Metal Tetraarylborates And Heteroleptic Tetraarylborate Pyrazolates, Ashley Clements

Honors Capstone Projects - All

Compounds containing s-block metals are highly sought after as precursor materials for the Metal Organic Chemical Vapor Deposition (MOCVD) process with applications for novel and improved electronic materials. Previous work in the Ruhlandt Group has been focused on the synthesis and characterization of novel homoleptic alkaline earth (Ae) metal pyrazolate and tetraarylborate complexes, while understanding the importance of secondary interactions such as M- in the isolation of these compounds. More recently, it was further proposed that the pyrazolate and tetraarylborate ligand systems combined with an Ae silyl amide via transamination may very well result in an improved heteroleptic MOCVD potential …

Pd-­Catalyzed N-­Arylation Of Amides: Catalyst Development And Scope, Tara Brenner

Honors Capstone Projects - All

Recent development toward more efficient palladium catalyzed amidation reactions has been driven by mechanistic studies and the development of more efficient ancillary phosphine ligands. This review discusses these developments with regard to substrate scope and the nature of the corresponding catalyst systems. Emphasis will be placed on applications of palladium catalyzed amidation reactions and the synthetic utility of these methods.

Design And Synthesis Of Solid State Materials Constructed From Polyoxomolybdate Clusters, Stephanie Jones

Chemistry - Dissertations

This work encompasses detailed investigations of the synthesis and structures of polyoxomolybdate materials. The design and synthesis of hybrid organic-inorganic materials constructed from various anionic polyoxomolybdate units and cationic secondary metal-ligand units, and the synthesis and ligand-exchange capacity of the giant polyoxomolybdate cluster Mo-132 are described. These studies aim to increase our understanding of the formation and physiochemical properties of these materials, and thereby aid in the ability to control and predict their structural chemistry.

The analysis of a number of structural determinants in the oxomolybdenum-organodiphosphonate system aims to expand the current knowledge of this family of materials. We have …

Exploring The Potential For B12-Based Oral Vaccine Delivery; Cubilin Mediated Uptake Of B12-Conjugate Systems Greater Than 160 Kda, Teresa Soldner

Honors Capstone Projects - All

This project aimed to create a novel oral tetanus vaccine by exploiting the B₁₂ uptake pathway. While many linkers were attempted, the only successful complex was created using CDT coupling. After synthesis, purification (with some difficulty), and characterization, tests were done in vitro and in vivo. These supported the conclusion that while the complex was being successfully taken up by the cell, the complex was not created a strong enough immune response for a positive titer. On a second note, simply the uptake of B₁₂-TT is remarkable because it is the largest molecule that has been …

The Synthesis And Characterization Of Novel Microporous Hybrid Organic/Inorganic Materials, Kelly Whitenack

Honors Capstone Projects - All

Inorganic chemistry is essential to the formulation and improvement of modern materials such as catalysts, semiconductors, optical devices, super conductors, and advanced ceramic materials.¹ New areas of inorganic chemistry are constantly being explored and new and often unusual inorganic compounds are constantly being synthesized and identified.¹ Recently the field of inorganic chemistry has witnessed the synthesis and characterization of microporous metal organic framework compounds (MOFs). Microporous organic/inorganic materials have a wide range of physical properties as well as applications. The physical properties and applications drive the investigation into the synthesis and discovery of new and useful hybrid MOF …

Rational Design And Synthesis Of Multifunctional Nanostructures For Biological And Medicinal Applications, Amy N. Otuonye

Honors Capstone Projects - All

Mobile Composite Material (MCM-41) was modified by the addition of various functional groups, which increase the materials’ efficiency for an assortment of applications. Mesoporous materials have demonstrated to be capable of adsorbing and releasing of model drug molecules, rhodamine 6G and ibuprofen. Mesoporous silica materials functionalized with mercaptopropyltrimethoxysilane (MPTS), vinyltrimethoxysilane (VTS), aminopropyltrimethoxysilane (APTS), and N-(2-animoethyl)-3-aminopropyltriethoxysilane (AAPTS) were used to test the adsorption and release of rhodamine 6G (R6G) and ibuprofen. The vinyl and mercaptopropyl groups adsorbed and released more rhodamine 6G than the primary and secondary amine groups. The adsorption and release of ibuprofen was the opposite of the R6G …

Synthesis Of Diruthenium Complexes As Connectable Molecular Components, George Ling

Honors Capstone Projects - All

There have been great advances in electronics and technology within the last few years. The field of nanotechnology can further improve electronics in terms of efficiency, size and costs. There exist nanowires and nanotransistors that could accomplish this, however there exists no good method of connecting the two components together. Using the bottom-up approach and chemical synthesis, the goal is to synthesize molecular jumper cables and connectable molecular components (CMCs).

The template of the CMC will have two ruthenium (Ru) metal centers connected by a conjugated, organic bridge. Coordinated to the ruthenium metal centers will be different ligands that affect …

Towards Novel Alkaline Earth Metal Pyrazolates: Opportunities In Materials Chemistry, Michael G. Bagnall

Honors Capstone Projects - All

Until recent years, the coordination chemistry of the alkaline earth metals remained relatively unexplored. Owing to the development of new synthetic methods and improved techniques for the exclusion of air and moisture, great progress has been made into our understanding of the alkaline earth metals and their compounds. These compounds are useful in a wide variety of applications, including as polymerization initiators, precursors for chemical vapor deposition (CVD) and in metal-organic frameworks (MOFs) for gas separation and storage. Current work in alkaline earth metal chemistry focuses on designing and tailoring ligand systems to expand their potential applications in materials chemistry. …

Novel Synthetic Routes Toward The Alkaline-Earth Metal Amides, Eli S. Mekhlin

Honors Capstone Projects - All

Metal organic chemical vapor deposition is a process used in the production of thin, crystalline films. The method involves the transportation of volatile, organometallic precursors to a heated substrate, where it undergoes chemical reactions to produce a thin, metallic layer on the substrate surface. Strontium and barium films of this nature are used as components in semi-conductor device fabrication, including among other things, the cell capacitors in Dynamic Random Access Memory computer chips. Additionally, organoalkaline-earth metal compounds are also desired for their potential to serve as polymerization initiators and reagents to modify polymers. Organocalcium derivatives are currently being explored as …

Synthesis Of Novel Alkaline Earth Metal Acetylides, Eva Baker

Honors Capstone Projects - All

Acetylide complexes of the heavy alkaline-earth metals were first introduced by our group. With our group being interested in how the ligand and donor affect the structural chemistry of the resulting complexes, my project was focused on the detailed analysis of past work and the extension towards new ligand and donor sets. The work required the analysis and development of synthetic procedures towards these highly reactive species.

Past synthetic work in our group had established several synthetic routes towards the target compounds including transamination and toluene elimination. Using toluene elimination, I was able to reproduce the synthesis of M(C≡CSiPh_{3 …}