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Full-Text Articles in Physical Sciences and Mathematics
Frataxin And Mitochondrial Fes Cluster Biogenesis, Timothy L. Stemmler, Emmanuel Lesuisse, Debumar Pain, Andrew Dancis
Frataxin And Mitochondrial Fes Cluster Biogenesis, Timothy L. Stemmler, Emmanuel Lesuisse, Debumar Pain, Andrew Dancis
Biochemistry and Molecular Biology Faculty Publications
Friedreich’s ataxia is an inherited neurodegenerative disease caused by frataxin deficiency. Frataxin is a conserved mitochondrial protein that plays a role in Fe-S cluster assembly in mitochondria. Fe-S clusters are modular cofactors that perform essential functions throughout the cell. They are synthesized by a multi-step and multi-subunit mitochondrial machinery that includes a scaffold protein Isu for assembling a protein bound Fe-S cluster intermediate. Frataxin interacts with Isu, iron, and with the cysteine desulfurase Nfs1 that supplies sulfur, thus placing it at the center of mitochondrial Fe-S cluster biosynthesis.
What Are The Causes, Consequences And Correctives Of Fish Contamination In The Detroit River Aoc That Cause Health Consumption Advisories? (Final Report, Michigan Sea Grant Michu-T-10-001), Donna R. Kashian, Ken G. Drouillard, D. Haffner, Ann E. Krause, Z Liu, Larissa Sano
What Are The Causes, Consequences And Correctives Of Fish Contamination In The Detroit River Aoc That Cause Health Consumption Advisories? (Final Report, Michigan Sea Grant Michu-T-10-001), Donna R. Kashian, Ken G. Drouillard, D. Haffner, Ann E. Krause, Z Liu, Larissa Sano
Environmental Science and Geology Faculty Research Publications
Using an Integrated Assessment (IA) framework, we consolidated and utilized existing data from the Detroit River to develop models that both identify possible drivers of elevated fish contaminant body burdens, and to facilitate a more risk-based approach of tissue trigger-levels for consumption advisories. This integrated assessment approach was particularly useful for consumption advisories as it provided the ability to integrate and organize complex data in a manner that can help inform management decisions. In addition, the IA framework explicitly fosters collaboration and participation of multiple interested groups. We have capitalized on this component of IAs, by seeking the active participation …