Physical Sciences and Mathematics Commons^™

Xic Clustering By Baseyian Network, Kyle J. Handy

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Exploring Population Change Detection By Monitoring Effective Number Of Breeders, Brian Trethewey

Graduate Student Theses, Dissertations, & Professional Papers

Detecting if a population is in decline is an important objective for biologists and conservationists who are monitoring threatened populations. As genetic methods improve effective population size (N_e) and effective number of breeders (N_b) continue to gain popularity as a way to monitor species. Using simulated populations and linkage disequilibrium, we explored detecting population decline through N_b in age structured populations. Through comparisons of sensitivity (1 – false negatives) and specificity (1- false positives) over 1000 replicates, we explored how factors such as starting N_b, number of SNPs, number of individuals …

Mirage: A Novel Multiple Protein Sequence Alignment Tool, Alex Nord

Graduate Student Theses, Dissertations, & Professional Papers

A fundamental problem in computational biology is the organization of many related sequences into a multiple sequence alignment (MSA) [2]. MSAs have a range of research applications, such as inferring phylogeny [22] and identifying regions of conserved sequence that indicate functional similarity [18]. In the case of protein isoforms, MSAs are valuable tools for transitively annotating post-translational modifications (PTMs) by enabling information transfer between known PTM sites and the sites that they align to [11].

For protein MSA tools, one challenging biological phenomenon is alternative splicing, wherein identical genomic sequence will differentially select from a subset of available coding regions …

K-Mer Analysis Pipeline For Classification Of Dna Sequences From Metagenomic Samples, Russell Kaehler

Graduate Student Theses, Dissertations, & Professional Papers

Biological sequence datasets are increasing at a prodigious rate. The volume of data in these datasets surpasses what is observed in many other fields of science. New developments wherein metagenomic DNA from complex bacterial communities is recovered and sequenced are producing a new kind of data known as metagenomic data, which is comprised of DNA fragments from many genomes. Developing a utility to analyze such metagenomic data and predict the sample class from which it originated has many possible implications for ecological and medical applications. Within this document is a description of a series of analytical techniques used to process …