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- Deep learning (5)
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Articles 31 - 56 of 56
Full-Text Articles in Physical Sciences and Mathematics
The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch
The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch
Mathematics, Physics, and Computer Science Faculty Articles and Research
Osteoporosis is the most common metabolic bone disease and goes largely undiagnosed throughout the world, due to the inaccessibility of DXA machines. Multivariate analyses of serum bone turnover markers were evaluated in 226 Orange County, California, residents with the intent to determine if serum osteocalcin and serum pyridinoline cross-links could be used to detect the onset of osteoporosis as effectively as a DXA scan. Descriptive analyses of the demographic and lab characteristics of the participants were performed through frequency, means and standard deviation estimations. We implemented logistic regression modeling to find the best classification algorithm for osteoporosis. All calculations and …
Investigating On Through Glass Via Based Rf Passives For 3-D Integration, Libo Qian, Jifei Sang, Yinshui Xia, Jian Wang, Peiyi Zhao
Investigating On Through Glass Via Based Rf Passives For 3-D Integration, Libo Qian, Jifei Sang, Yinshui Xia, Jian Wang, Peiyi Zhao
Mathematics, Physics, and Computer Science Faculty Articles and Research
Due to low dielectric loss and low cost, glass is developed as a promising material for advanced interposers in 2.5-D and 3-D integration. In this paper, through glass vias (TGVs) are used to implement inductors for minimal footprint and large quality factor. Based on the proposed physical structure, the impact of various process and design parameters on the electrical characteristics of TGV inductors is investigated with 3-D electromagnetic simulator HFSS. It is observed that TGV inductors have identical inductance and larger quality factor in comparison with their through silicon via counterparts. Using TGV inductors and parallel plate capacitors, a compact …
Atomistic Simulations And Network-Based Modeling Of The Hsp90-Cdc37 Chaperone Binding With Cdk4 Client Protein: A Mechanism Of Chaperoning Kinase Clients By Exploiting Weak Spots Of Intrinsically Dynamic Kinase Domains, John Czemeres, Kurt Buse, Gennady M. Verkhivker
Atomistic Simulations And Network-Based Modeling Of The Hsp90-Cdc37 Chaperone Binding With Cdk4 Client Protein: A Mechanism Of Chaperoning Kinase Clients By Exploiting Weak Spots Of Intrinsically Dynamic Kinase Domains, John Czemeres, Kurt Buse, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
A fundamental role of the Hsp90 and Cdc37 chaperones in mediating conformational development and activation of diverse protein kinase clients is essential in signal transduction. There has been increasing evidence that the Hsp90-Cdc37 system executes its chaperoning duties by recognizing conformational instability of kinase clients and modulating their folding landscapes. The recent cryo-electron microscopy structure of the Hsp90-Cdc37- Cdk4 kinase complex has provided a framework for dissecting regulatory principles underlying differentiation and recruitment of protein kinase clients to the chaperone machinery. In this work, we have combined atomistic simulations with protein stability and network-based rigidity decomposition analyses to characterize dynamic …
A Cluster Analysis Of Challenging Behaviors In Autism Spectrum Disorder, Elizabeth Stevens, Abigail Atchison, Laura Stevens, Esther Hong, Doreen Granpeesheh, Dennis Dixon, Erik J. Linstead
A Cluster Analysis Of Challenging Behaviors In Autism Spectrum Disorder, Elizabeth Stevens, Abigail Atchison, Laura Stevens, Esther Hong, Doreen Granpeesheh, Dennis Dixon, Erik J. Linstead
Mathematics, Physics, and Computer Science Faculty Articles and Research
We apply cluster analysis to a sample of 2,116 children with Autism Spectrum Disorder in order to identify patterns of challenging behaviors observed in home and centerbased clinical settings. The largest study of this type to date, and the first to employ machine learning, our results indicate that while the presence of multiple challenging behaviors is common, in most cases a dominant behavior emerges. Furthermore, the trend is also observed when we train our cluster models on the male and female samples separately. This work provides a basis for future studies to understand the relationship of challenging behavior profiles to …
An Evaluation Of The Effects Of Intensity And Duration On Outcomes Across Treatment Domains For Children With Autism Spectrum Disorder, Erik J. Linstead, D. R. Dixon, E. Hong, C. O. Burns, Ryan French, M. N. Novack, D. Granpeesheh
An Evaluation Of The Effects Of Intensity And Duration On Outcomes Across Treatment Domains For Children With Autism Spectrum Disorder, Erik J. Linstead, D. R. Dixon, E. Hong, C. O. Burns, Ryan French, M. N. Novack, D. Granpeesheh
Mathematics, Physics, and Computer Science Faculty Articles and Research
Applied behavior analysis (ABA) is considered an effective treatment for individuals with autism spectrum disorder (ASD), and many researchers have further investigated factors associated with treatment outcomes. However, few studies have focused on whether treatment intensity and duration have differential influences on separate skills. The aim of the current study was to investigate how treatment intensity and duration impact learning across different treatment domains, including academic, adaptive, cognitive, executive function, language, motor, play, and social. Separate multiple linear regression analyses were used to evaluate these relationships. Participants included 1468 children with ASD, ages 18 months to 12 years old, M= …
Relation Algebras, Idempotent Semirings And Generalized Bunched Implication Algebras, Peter Jipsen
Relation Algebras, Idempotent Semirings And Generalized Bunched Implication Algebras, Peter Jipsen
Mathematics, Physics, and Computer Science Faculty Articles and Research
This paper investigates connections between algebraic structures that are common in theoretical computer science and algebraic logic. Idempotent semirings are the basis of Kleene algebras, relation algebras, residuated lattices and bunched implication algebras. Extending a result of Chajda and Länger, we show that involutive residuated lattices are determined by a pair of dually isomorphic idempotent semirings on the same set, and this result also applies to relation algebras. Generalized bunched implication algebras (GBI-algebras for short) are residuated lattices expanded with a Heyting implication. We construct bounded cyclic involutive GBI-algebras from so-called weakening relations, and prove that the class of weakening …
Computational Analysis Of Residue Interaction Networks And Coevolutionary Relationships In The Hsp70 Chaperones: A Community- Hopping Model Of Allosteric Regulation And Communication, Gabrielle Stetz, Gennady M. Verkhivker
Computational Analysis Of Residue Interaction Networks And Coevolutionary Relationships In The Hsp70 Chaperones: A Community- Hopping Model Of Allosteric Regulation And Communication, Gabrielle Stetz, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
Allosteric interactions in the Hsp70 proteins are linked with their regulatory mechanisms and cellular functions. Despite significant progress in structural and functional characterization of the Hsp70 proteins fundamental questions concerning modularity of the allosteric interaction networks and hierarchy of signaling pathways in the Hsp70 chaperones remained largely unexplored and poorly understood. In this work, we proposed an integrated computational strategy that combined atomistic and coarse-grained simulations with coevolutionary analysis and network modeling of the residue interactions. A novel aspect of this work is the incorporation of dynamic residue correlations and coevolutionary residue dependencies in the construction of allosteric interaction networks …
Qubit Measurement Error From Coupling With A Detuned Neighbor In Circuit Qed, Mostafa Khezri, Justin Dressel, Alexander N. Korotkov
Qubit Measurement Error From Coupling With A Detuned Neighbor In Circuit Qed, Mostafa Khezri, Justin Dressel, Alexander N. Korotkov
Mathematics, Physics, and Computer Science Faculty Articles and Research
In modern circuit QED architectures, superconducting transmon qubits are measured via the state-dependent phase and amplitude shift of a microwave field leaking from a coupled resonator. Determining this shift requires integrating the field quadratures for a nonzero duration, which can permit unwanted concurrent evolution. Here we investigate such dynamical degradation of the measurement fidelity caused by a detuned neighboring qubit. We find that in realistic parameter regimes, where the qubit ensemble-dephasing rate is slower than the qubit-qubit detuning, the joint qubit-qubit eigenstates are better discriminated by measurement than the bare states. Furthermore, we show that when the resonator leaks much …
Detection And Tracking Of T Cells In Time-Lapse Imaging, Cody Arbuckle, Milton L. Greenberg, Erik J. Linstead
Detection And Tracking Of T Cells In Time-Lapse Imaging, Cody Arbuckle, Milton L. Greenberg, Erik J. Linstead
Mathematics, Physics, and Computer Science Faculty Articles and Research
The effective classification and tracking of cells obtained from modern staining techniques has significant limitations due to the necessity of having to train and utilize a human expert in the field who must manually identify each cell in each slide. Often times these slides are filled with noise cells that are not of particular interest to the researcher. The use of computational methods has the ability to effectively and efficiently enhance image quality, as well as identify and track target cell types over large data sets. Here we present a computational approach to the in vitro tracking of T cells …
Two-Language, Two-Paradigm Introductory Computing Curriculum Model And Its Implementation, Vladimir Zanev, Atanas Radenski
Two-Language, Two-Paradigm Introductory Computing Curriculum Model And Its Implementation, Vladimir Zanev, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
This paper analyzes difficulties with the introduction of object-oriented concepts in introductory computing education and then proposes a two-language, two-paradigm curriculum model that alleviates such difficulties. Our two-language, two-paradigm curriculum model begins with teaching imperative programming using Python programming language, continues with teaching object-oriented computing using Java, and concludes with teaching object-oriented data structures with Java.
Freedom Of Choice As A Motivational Factor In Active Learning, Atanas Radenski
Freedom Of Choice As A Motivational Factor In Active Learning, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Freedom to choose what, when, and how to contribute in a learning process can motivate students to actively engage and achieve more in their studies. However, freedom of choice complicates course management and may deter instructors from allowing such freedom. Our approach is to utilize existing functionality of course management systems such as Moodle to automatically facilitate and coordinate free student choices and provide much needed relief for instructors at the same time. Using Moodle we have developed novel digital study packs that blend freedom of choice with guidance and control. Our survey shows that assisted freedom of choice is …
The Java 5 Generics Compromise Orthogonality To Keep Compatibility, Atanas Radenski, Jeff Furlong, Vladimir Zanev
The Java 5 Generics Compromise Orthogonality To Keep Compatibility, Atanas Radenski, Jeff Furlong, Vladimir Zanev
Mathematics, Physics, and Computer Science Faculty Articles and Research
In response to a long-lasting anticipation by the Java community, version 1.5 of the Java 2 platform - referred to as Java 5 - introduced generic types and methods to the Java language. The Java 5 generics are a significant enhancement to the language expressivity because they allow straightforward composition of new generic classes from existing ones while reducing the need for a plethora of type casts. While the Java 5 generics are expressive, the chosen implementation method, type erasure, has triggered undesirable orthogonality violations. This paper identifies six cases of orthogonality violations in the Java 5 generics and demonstrates …
Patterns For Active E-Learning In Cms Environments, Atanas Radenski
Patterns For Active E-Learning In Cms Environments, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
The proliferation of course management systems (CMS) in the last decade stimulated educators in establishing novel active e-learning practices. Only a few of these practices, however, have been systematically described and published as pedagogic patterns. The lack of formal patterns is an obstacle to the systematic reuse of beneficial active e-learning experiences. This paper aims to partially fill the void by offering a collection of active e-learning patterns that are derived from our continuous course design experience in standard CMS environments, such as Moodle and Black-board. Our technical focus is on active e-learning patterns that can boost student interest in …
Digital Support For Abductive Learning In Introductory Computing Courses, Atanas Radenski
Digital Support For Abductive Learning In Introductory Computing Courses, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Students who grew up browsing the Web are skilled in what is usually referred to as abduction, a reasoning process that starts with a set of specific observations and then generates the best possible explanation of those observations. In order to exploit the abduction skills of contemporary students, we have developed digital CS1/2 study packs that promote and support active learning through abduction, i.e., abductive learning. The study packs integrate a variety of digital resources: online self-guided labs, e-texts, tutorial links, sample programs, quizzes, and slides. These online packs stimulate students to learn abductively by browsing, searching, and performing self-guided …
Python First: A Lab-Based Digital Introduction To Computer Science, Atanas Radenski
Python First: A Lab-Based Digital Introduction To Computer Science, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
The emphasis on Java and other commercial languages in CS1 has established the perception of computer science as a dry and technically difficult discipline among undecided students who are still seeking careers. This may not be a big problem during an enrolment boom, but in times of decreased enrolment such negative perception may have a devastating effect on computer science programs and therefore should not be ignored. We have made our CS1 course offerings more attractive to students (1) by introducing an easy to learn yet effective scripting language - Python, (2) by making all course resources available in a …
Computational Sciences: At The Intersection Of Science And Engineering - Case Study For Academic And Research Programs, Menas Kafatos, P. A. Becker, Z. Boybeyi
Computational Sciences: At The Intersection Of Science And Engineering - Case Study For Academic And Research Programs, Menas Kafatos, P. A. Becker, Z. Boybeyi
Mathematics, Physics, and Computer Science Faculty Articles and Research
No abstract provided.
Handling The Subclassing Anomaly With Object Teams, Jeff Furlong, Atanas Radenski
Handling The Subclassing Anomaly With Object Teams, Jeff Furlong, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Existing Java software or libraries can evolve via subclassing. Unfortunately, subclassing may not properly support code adaptation when there are dependencies between classes. More precisely, subclassing in collections of related classes may require reimplementation of otherwise valid classes. This problem is defined as the subclassing anomaly, which is an issue when software evolution or code reuse is a goal of the programmer who is using existing classes. Object Teams offers an implicit fix to this problem and is largely compatible with the existing JVM’s. In this paper, we evaluate how well Object Teams succeeds in providing a solution for a …
Anomaly-Free Component Adaptation With Class Overriding, Atanas Radenski
Anomaly-Free Component Adaptation With Class Overriding, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Software components can be implemented and distributed as collections of classes, then adapted to the needs of specific applications by means of subclassing. Unfortunately, subclassing in collections of related classes may require re-implementation of otherwise valid classes just because they utilize outdated parent classes, a phenomenon that is referred to as the subclassing anomaly. The subclassing anomaly is a serious problem since it can void the benefits of component-based programming altogether. We propose a code adaptation language mechanism called class overriding that is intended to overcome the subclassing anomaly. Class overriding does not create new and isolated derived classes as …
The Subclassing Anomaly In Compiler Evolution, Atanas Radenski
The Subclassing Anomaly In Compiler Evolution, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Subclassing in collections of related classes may require re-implementation of otherwise valid classes just because they utilize outdated parent classes, a phenomenon that is referred to as the subclassing anomaly. The subclassing anomaly is a serious problem since it can void the benefits of code reuse altogether. This paper offers an analysis of the subclassing anomaly in an evolving object-oriented compiler. The paper also outlines a solution for the subclassing anomaly that is based on alternative code reuse mechanism, named class overriding.
Object-Oriented Programming And Parallelism, Atanas Radenski
Object-Oriented Programming And Parallelism, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Initially, object-orientation and parallelism originated and developed as separate and relatively independent areas. During the last decade, however, more and more researchers were attracted by the benefits from a potential marriage of the two powerful paradigms. Numerous research projects and an increasing number of practical applications were aimed at different forms of amalgamation of parallelism with object-orientation. It has been realized that parallelism is a inherently needed enhancement for the traditional object-oriented programming (OOP) paradigm, and that object orientation can add significant flexibility to the parallel programming paradigm.
Module Embedding, Atanas Radenski
Module Embedding, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
This paper proposes a code reuse mechanism called module embedding that enables the building of new modules from existing ones through inheritance, overriding of procedures, and overriding of types; the paper also describes an implementation scheme for this mechanism. Module embedding is beneficial when modules and classes are used in combination and need to be extended together, or when modules are more appropriate medium than classes.
Introducing Objects And Parallelism To An Imperative Programming Language, Atanas Radenski
Introducing Objects And Parallelism To An Imperative Programming Language, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
The problem of enhancing objects with parallelism has been in the focus of numerous research projects in the recent years, but a satisfactory and commonly accepted solution has not appeared yet. A major problematic point seems to be providing inheritance for parallel objects. The general objective of this paper is to contribute to a better understanding of the language design issues in the area of parallel object-oriented programming (OOP) and, in particular, to design a framework for parallel OOP with multiple inheritance. What makes our proposed framework different from the other parallel OOP languages is its easy to use and …
Lazy Evaluation And Nondeterminism Make Backus' Fp-Systems More Practical, Atanas Radenski
Lazy Evaluation And Nondeterminism Make Backus' Fp-Systems More Practical, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Backus' FP-systems are made more practical by introducing into them lazy evaluation and nondeterminism. This is done in the framework of a concrete programming language called FP*. From the one hand, this language is almost as mathematical as FP-systems are. From the other hand, it gives the possibility to manage secondary memory and to develop such applications as, for instance, interactive and distributed file systems. Experimental versions of a compiler and an interpreter for the FP* language are implemented.
On Some Dependencies Between Functional Forms In Functional Programming Systems, Atanas Radenski
On Some Dependencies Between Functional Forms In Functional Programming Systems, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
In the present paper, some dependencies between functional forms in functional programming systems are demonstrated. It is shown that any functional form can be expressed by using only the forms composition, condition and construction.
Structure Of The Information Base And Operations On The Entities In A System For Information Servicing Of Collectivities, Peter H. Barnev, Atanas Radenski
Structure Of The Information Base And Operations On The Entities In A System For Information Servicing Of Collectivities, Peter H. Barnev, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
This paper treats, from an user point of view, the structure of the entities in the information base (IB) of a System for information servicing of collectivities (SISC) as well as the operations on these entries.
An Algorithm For Finding All Isomorphisms Of Two Graphs, Atanas Radenski
An Algorithm For Finding All Isomorphisms Of Two Graphs, Atanas Radenski
Mathematics, Physics, and Computer Science Faculty Articles and Research
No abstract provided.