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Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Honors Theses
The synthesis of both cis and trans-RuCl?(DMSO)? has been reported in literature, and is currently the only way of acquiring these compounds. Because these metallodrugs have shown similar antitumor properties to cisplatin, they are currently under investigation for use in clinical trials as potential chemotherapeutics. It is believed that these drugs act in a way similar to cisplatin by causing intrastrand crosslinking of adjacent guanine residues in DNA. In an attempt to better understand any Ru/DNA interaction for these compounds, both cis and trans-RuCl?(DMSO)? were synthesized with reasonable yields (~40%). The compounds were then characterized by nuclear magnetic resonance (NMR), …