Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- ?-Acetoxycarbene (1)
- Antineoplastic agents (1)
- Arene interactions (1)
- Aromatic compounds (1)
- Carbenes (Methylene compounds) (1)
-
- Cooperative binding (1)
- Copper (1)
- DNA -- Structure (1)
- DNA-drug interactions (1)
- DNA-ligand interactions (1)
- Diepoxide DNA (1)
- Ligand binding (1)
- Mass media -- Political aspects -- United States (1)
- NS2-macrocyclic ligand (1)
- Nucleoproteins -- Purification (1)
- Pendant aryl arms (1)
- Photochemistry (1)
- Proteins -- Purification (1)
- Purines (1)
- Ruthenium synthesis (1)
- Television and politics -- United States (1)
- Transition metal complexes synthesis (1)
- United States -- Politics and government (1)
Articles 1 - 12 of 12
Full-Text Articles in Physical Sciences and Mathematics
Weinreb Amides : Novel Titanium Enolate Reagents, Andrew J. Leyhane
Weinreb Amides : Novel Titanium Enolate Reagents, Andrew J. Leyhane
Honors Theses
The amides of N-methoxy-N-methylamine or "Weinreb amide" have earned an important role in synthetic chemistry as both a protective group and as synthetic intermediates. We have discovered that the Weinreb amide of acetic acid, N-methoxy-N-methylacetamide adds to aldehydes to afford classic aldol products in good to excellent yields. The scope of this novel aldol reaction will be discussed.
Inclusion Chemistry Of Neutral Nonlinear Optical Dyes Within Organically Modified Silicates, Ian Saratovsky
Inclusion Chemistry Of Neutral Nonlinear Optical Dyes Within Organically Modified Silicates, Ian Saratovsky
Honors Theses
The field of photonics involves the use of light to acquire, store, process, and transmit information. Nonlinear optical (NLO) materials are crucial for success in the advancement of photonic devices. Laponite and hectorite host assemblies have been shown previously by our group to induce I -aggregation of nonlinear optical (NLO) dyes and offer facile routes to film fabrication. Head-to-tail alignment (J-aggregation) of the NLO chromophores is a required condition for photonic applications. In this study, tetrabutylammonium, triethylhexylammonium, trimethyldodecylammonium, and trimetylcetylarunonium surfactants were utilized to render the smectic intergallery region organophilic thus facilitating chromophore intercalation and an increased J-aggregated dye fraction. …
A Stereoselective Multi-Component Synthesis Of Alpha-Oxy-Beta-Substituted-Beta-Amino Esters, Avrum L. Joffe
A Stereoselective Multi-Component Synthesis Of Alpha-Oxy-Beta-Substituted-Beta-Amino Esters, Avrum L. Joffe
Honors Theses
Previous work has shown that chlorotitanium enolates of methylmethoxy acetate add to aryl aldimines in a stereoselective fashion. Aryl aldimines are non-enolizable, which contributes to their ability to add to the enolates. Previous attempts to add the enolates to enolizable alkyl aldimines were unsuccessful. By using a multi-component process in which the aldimine is synthesized in-situ, we have expanded the scope of this chemistry to the enolizable alkyl aldimines. Furthermore, the multi-component process has proven to be stereoselective for the anti-adduct.
The Use Of Substituted Cyclodextrins In Capillary Electrophoresis For The Separation And Identification Of Methorphan Enantiomers, Colleen Strait
The Use Of Substituted Cyclodextrins In Capillary Electrophoresis For The Separation And Identification Of Methorphan Enantiomers, Colleen Strait
Honors Theses
The goal of this project was to separate the enantiomers levo and dextromethorphan using capillary electrophoresis (CE). Levomethorphan is a controlled substance, and dextromethorphan is an active ingredient in many cough syrups. Methylated-β-cyclodextrins (CDs) are used as additives because the CDs have chiral centers, allowing them to bind differently to the two enantiomers and thereby changing the enantiomer migration times in CE. Dimethyl- β-CD did not separate the levo and dextromethorphans; however the trimethyl-β-CD was successful at producing baseline separation with migration times of roughly 6 minutes. We are optimizing it by changing variables such as type of buffer, buffer …
The Optimization Of Sol-Gels As Sensing Arrays And The Testing Of Sol-Gel Precursors Through The Use Of Fluorescence Measurements Of Eosin-Y, Rachel M. Bukowski
The Optimization Of Sol-Gels As Sensing Arrays And The Testing Of Sol-Gel Precursors Through The Use Of Fluorescence Measurements Of Eosin-Y, Rachel M. Bukowski
Honors Theses
The purpose of the first project, performed in collaboration with Professor Frank Bright of SUNY at Buffalo, was to optimize the conditions and variables for a Cartesian Technologies Pinprinter to print reproducible spots of sol-gels doped with Ruthenium Diphenylphenathrene (Ru(dpp)32+), an oxygen-sensing complex, on microscope slides. We attempted to optimize these variables by l) the alteration of the printing speed of the sol-gel microarrays, 2) variation of the drying temperature of the gels after they had been printed, 3) controlling the reaction rate of the sol-gel, and 4) various methods of slide pre-treatment. We found that a print speed of …
The Optimization Of Sol-Gels As Sensing Arrays And The Testing Of Sol-Gel Precursors Through The Use Of Fluorescence Measurements Of Eosin-Y, Rachel M. Bukowski
The Optimization Of Sol-Gels As Sensing Arrays And The Testing Of Sol-Gel Precursors Through The Use Of Fluorescence Measurements Of Eosin-Y, Rachel M. Bukowski
Honors Theses
The purpose of the first project, performed in collaboration with Professor Frank Bright of SUNY at Buffalo, was to optimize the conditions and variables for a Cartesian Technologies Pinprinter to print reproducible spots of sol-gels doped with Ruthenium Diphenylphenathrene (Ru(dpp)32+), an oxygen-sensing complex, on microscope slides. We attempted to optimize these variables by l) the alteration of the printing speed of the sol-gel microarrays, 2) variation of the drying temperature of the gels after they had been printed, 3) controlling the reaction rate of the sol-gel, and 4) various methods of slide pre-treatment. We found that a print speed of …
Communicator-In-Chief: Presidential Use Of Television Past, Present, And Future, Jenna Wasson
Communicator-In-Chief: Presidential Use Of Television Past, Present, And Future, Jenna Wasson
Honors Theses
This thesis seeks to determine how television has changed as a communication medium for presidents over the past half century. An evaluation of the evolving ways presidents use television to communicate with and to build support from the American people has been conducted. Presidential communication strategies have been identified by drawing primarily from primary sources written by presidents and White House staff. Television technology and the television audience have changed over the years. Presidents have taken a more pro-active, aggressive role in their efforts to harness television for their own purposes. Why have these changes occurred? What impact have these …
Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Honors Theses
The synthesis of both cis and trans-RuCl?(DMSO)? has been reported in literature, and is currently the only way of acquiring these compounds. Because these metallodrugs have shown similar antitumor properties to cisplatin, they are currently under investigation for use in clinical trials as potential chemotherapeutics. It is believed that these drugs act in a way similar to cisplatin by causing intrastrand crosslinking of adjacent guanine residues in DNA. In an attempt to better understand any Ru/DNA interaction for these compounds, both cis and trans-RuCl?(DMSO)? were synthesized with reasonable yields (~40%). The compounds were then characterized by nuclear magnetic resonance (NMR), …
Photochemical Generation And Chemistry Of Α-Acetoxycarbene, Jonathan Mann
Photochemical Generation And Chemistry Of Α-Acetoxycarbene, Jonathan Mann
Honors Theses
Efforts have been made at generating the parent α-acetoxycarbene from a non-nitrogenous precursor. Baeyer-Villiger oxidation of the ketone, 1-(1a,9b-dihydro-lHcyclopropa[1] phenanthren-1-yl)-ethanone, available in two steps from phenanthrene, led to the ester, 1-(1 a,9b-dihydro-lH-cyclopropa[/]phenanthren-l-yl)-acetate, which is a photochemical precursor of the parent α-acetoxycarbene intermediate. Photolysis of the ester in cyclohexene afforded an isomeric mixture of endo and exo acetates resulting from the carbene adding to the α-bond. Photolysis of the ester in trans-3-hexene yielded a single trans-cis acetate, a product of the same cycloaddition process. The formation of methyl glyoxal, via the l,2-acyl shift of the carbene, is observed through its derivatives. …
Purification Of The Hmg1 Protein And Investigation Of Its Interactions With Diepoxide Cross-Linked Dna, Gayle Pageau
Purification Of The Hmg1 Protein And Investigation Of Its Interactions With Diepoxide Cross-Linked Dna, Gayle Pageau
Honors Theses
HMG1 is a nonhistone chromosomal protein that binds preferentially to some types of globally modified DNA. HMG1 has been implicated in the cellular response to the anti-cancer agent cisplatin, functioning to block excision repair of specific distorted platinated DNA lesions and resulting in enhanced cytotoxicity. We have investigated whether other DNA-binding agents also produce lesions that are recognized by HMG1. Specifically, we used polyacrylamide gel shift assays to monitor the potential HMG1 binding of diepoxybutane interstrand cross-links, which have been suggested to induce DNA bending. We isolated the native protein from chicken erythrocytes and expressed engineered HMG domain proteins in …
Investigations Of Intramolecular Copper (I)-Arene Interactions Using A Ns2-Macrocyclic Ligand With Different Pendant Aryl Arms, Paul J. Lee
Honors Theses
Two macrocyclic ligands with a pendant phenyl group -N-[2-(l-phenyl)ethyl]-1-aza-4,8di thiacyclodecane (L1) and N-[2-0-phenyl)propyl]-1-aza-4,8-dithiacyclodecane, (L2) has been synthesized and characterized. The copper(I)-triphenylphosphine complex [LICu(PPhJ)]OTf , (2) was synthesized from L1 1/2(C6H6)[CuOTf]2, and PPh3. The complexes [LICu]OTf 1 and [L2Cu]OTf 3 were also synthesized and characterized using DC and IH NMR, UV-vis and lR spectroscopy, and ESI-MS. In CD2Cl2, 1 was found to have a fluxional behavior with the barrier ΔG to the process estimated at 9-11 kcal/mol. Variable temp. NMR spectroscopy of 1 gave compelling evidence that the phenylappended group is bound in an intramolecullar η2-fashion with the copper center. At …
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Honors Theses
6-Thioguanine (65G) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia. Despite its long-standing clinical use, little is understood of the molecular basis of the cytotoxicity associated with ?sG. Research has shown that ?sG is incorporated into DNA during replication after which it may exert its cytotoxicity by inducing rapid mutation or by affecting DNA-protein interactions. 65G has also been shown to impair HIV replication by inhibiting HlV-l reverse transcriptase and to inhibit human telomerase activity. To further understand the structural changes associated …