Physical Sciences and Mathematics Commons^™

Interactions Of Ti(Iv) And Sn(Iv) Organometallic Complexes With Double-Stranded Dna, Katherine Macdonald Davies

Honors Theses

In order to understand further the interactions that exist between specific organometallic complexes and DNA, reactions of double-stranded calf-thymus DNA with bis(cyclopentadienyl)titanium dichloride [Cp₂TiC1₂] (TDC), bis(t-butylcyclopentadienyl)titanium dichloride [(C₄H₉Cp)₂TiC1₂] (r-butyl TDC), bis(i-propylcyclopentadienly)titanium dichloride [(C₃H₆Cp)2TiCl₂ a-propyl mc), bis(pentamethylcyclopentadienyl) titanium dichloride [(Cp"₂TiC1₂ (pentarnethyl TDC), triphenyltin chloride (Ph₃SnCl), diphenylrin dichloride (Ph₂SnC1₂) , and triphenyltin acetate (Ph₃SnOAc) were performed. The goal of this research is to establish how the fundamental structure and composition of these compounds determine the effecti veness of their DNA interactions. Each metal compound was incubated with calf thymus DNA at several metal: DNA ratios and reactions were maintained at 37°C at …