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Articles 1 - 11 of 11
Full-Text Articles in Physical Sciences and Mathematics
Forensic Applications Of Capillary Electrophoresis, Jennifer A. Jakubowski
Forensic Applications Of Capillary Electrophoresis, Jennifer A. Jakubowski
Honors Theses
The separation by capillary zone electrophoresis (CZE) of the chiral narcotic propoxyphene is the goal of this work. A three-way collaboration between our research group, Professor lsiah Warner (LSU), and the New York State Forensic Investigation Center is underway, with the goal of separating controlled substances and developing techniques that the Forensic Center can apply in it& investigations. Earlier studies by Warner's group have shown that using polymerized N-undecylenyl-L-amino acid and peptide derivatives as pseudo-stationary phases in CZE has resulted in the separation of chiral molecules. Our separations were attempted by combining the drug samples with polymerized N-undecylenyl-L-amino acid and …
Stereoselection In The Preparation Of Alpha-Oxy-Beta-Amino Esters : Revealing The Mechanism, Richard James Fox
Stereoselection In The Preparation Of Alpha-Oxy-Beta-Amino Esters : Revealing The Mechanism, Richard James Fox
Honors Theses
Due to their significant pharmaceutical applications, the development of efficient, stereoselective synthetic routes for the preparation of α-substituted-β-amino esters has become increasingly important. We demonstrated that the titanium enolates (47) of a.alkoxy acetate esters (48) add cleanly to imines (49), and predominately afford the anti diastereomer of the a.-oxy-f3-amino ester product (50). Furthermore, by altering the electronic properties of the ether oxygen, sterics of the ester and temperature conditions, we changed the anti:syn product ratio. We rationalized the origin of these effects, and proposed a mechanism of imine addition.
Diastereoselection In Titanium Enolate Addition To Aldmines, Julia Leigh Barkin
Diastereoselection In Titanium Enolate Addition To Aldmines, Julia Leigh Barkin
Honors Theses
A mild and versatile synthesis of a-oxy-6-amino esters has been performed by condensation of the chlorotitanium enolates of methyl methoxyacetate with aldimines. The imine-aldol addition occurs in excellent yields without Lewis acid activation of the imine. All aryl imines examined show good to excellent diastereoselection for the anti isomers.
Fluorescence Studies Of Tris (2,2'-Bipyridine) Ruthenium (Ii) In Thin Clay Films, Samuel James Salamone
Fluorescence Studies Of Tris (2,2'-Bipyridine) Ruthenium (Ii) In Thin Clay Films, Samuel James Salamone
Honors Theses
Because of their rich intercalation chemistry and ability to enhance the thermal stability of the included guest, layered silicate clays are excellent hosts for the fabrication of organic/inorganic nanocomposites. Composites of hectorite and tris(2, 2' -bipyridine) ruthenium(U), Ru(bpy), 3 2+, have attracted attention owing to their potential applications as glucose and oxygen based chemical sensors. Previous studies on the fluorescence behavior of Ru(bpy)3 2+ complexes in aqueous colloidal clay suspensions have shown enhanced emission traces. We report here the first study of the fluorescence responses of Ru(bpy) 3 2+ exchanged thin clay films. Variation of guest concentration and exposure time …
Determination Of The Wavelength Dependence On The Metal Catalyzed Degradation Of The Herbicide Atrazine, Timothy Bertram
Determination Of The Wavelength Dependence On The Metal Catalyzed Degradation Of The Herbicide Atrazine, Timothy Bertram
Honors Theses
Since the advent of modern herbicide use in the early twentieth century, researchers have been plagued with the obvious problem of herbicide disposal. Most herbicides are specifically designed to resist natural degradation processes so that they can remain effective in the field for a substantial amount of time. In addition, they are also made water soluble so that they can be easily applied to crops. Finally, they are specifically produced to kill undesirable plant species in the quickest and often crudest fashions. Due to these specific properties herbicides pose a general threat to other organisms living in the same geographic …
Cisplatin Interstrand Cross-Linking Of Defined Sequence Nucleosomal Dna, Erin Elizabeth Wilkes
Cisplatin Interstrand Cross-Linking Of Defined Sequence Nucleosomal Dna, Erin Elizabeth Wilkes
Honors Theses
DNA interstrand cross-linking agents have been recognized for many years to be powerful antitumor chemotherapeutics. While the interactions between free DNA and many anticancer drugs have been explored extensively, there is less infonnation available about these interactions with nucleosomal DNA. Nitrogen mustards have been reported to exhibit relatively similar cross-linking sites and efficiencies of binding in free and nucleosomal DNA, but mitomycin C exhibits markedly reduced cross-linking near the center of nucleosomal DNA. This current study focuses on cisplatin interstrand cross-linking of the 154 base pair 55 rRNA gene fragment of Xenopus borealis reconstituted with histones from chicken erythrocytes. The …
A Computational Approach To Determining Stability Constants For Transition Metal Ion Complexes, Jason St. Clair
A Computational Approach To Determining Stability Constants For Transition Metal Ion Complexes, Jason St. Clair
Honors Theses
The complexation of metal ions in natural waters plays a critical role in defining the metal's biogeochemistry, Numerous investigators have used various experimental techniques to measure complexation constants in the laboratory, but many constants are still poorly undefined or have yet to be investigated due to the difficulty of some of the experiments. A computational approach to obtaining these constants for complexes of Fe(lII), Fe(D), Cr(lli), Cu(lI), Zn(II), and Cd(II) was explored with varying degrees of success. Calculated Gibbs Free Energies were compared to experimental stability constants. Calculations were performed using Spartan's DFT package at the pEP level and with …
Friction Of (110) Diamond In The Presence Of Small Hydrocarbon Molecule, Catherine Manning
Friction Of (110) Diamond In The Presence Of Small Hydrocarbon Molecule, Catherine Manning
Honors Theses
Molecular dynamic simulations have been used to explore the friction between two (110) diamond surfaces in sliding contact. In general, when a third-body hydrocarbon molecule is placed between two computer generated diamond surfaces in sliding contact, the result is a reduction of friction as the load iH increased compared to the same surfaces in the absence of third-body molecules. The size, shape, and alignment of the third-body hydrocarbon molecules play an essential role in the reduction of friction. Results for a system with ethane presented as a third-body molecule will be compared to previous theoretical studies as well as existing …
Interactions Of Ti(Iv) And Sn(Iv) Organometallic Complexes With Double-Stranded Dna, Katherine Macdonald Davies
Interactions Of Ti(Iv) And Sn(Iv) Organometallic Complexes With Double-Stranded Dna, Katherine Macdonald Davies
Honors Theses
In order to understand further the interactions that exist between specific organometallic complexes and DNA, reactions of double-stranded calf-thymus DNA with bis(cyclopentadienyl)titanium dichloride [Cp₂TiC1₂] (TDC), bis(t-butylcyclopentadienyl)titanium dichloride [(C₄H₉Cp)₂TiC1₂] (r-butyl TDC), bis(i-propylcyclopentadienly)titanium dichloride [(C₃H₆Cp)2TiCl₂ a-propyl mc), bis(pentamethylcyclopentadienyl) titanium dichloride [(Cp"₂TiC1₂ (pentarnethyl TDC), triphenyltin chloride (Ph₃SnCl), diphenylrin dichloride (Ph₂SnC1₂) , and triphenyltin acetate (Ph₃SnOAc) were performed. The goal of this research is to establish how the fundamental structure and composition of these compounds determine the effecti veness of their DNA interactions. Each metal compound was incubated with calf thymus DNA at several metal: DNA ratios and reactions were maintained at 37°C at …
A Catechol Approach To Natural Product Synthesis, Michelle E. Weber
A Catechol Approach To Natural Product Synthesis, Michelle E. Weber
Honors Theses
This research has focused on the total synthesis of the iron--chelating natural product 1-(2,3-hydroxyphenyl)-4-methoxy-I-butanone. An extract of the iron-cleficient fungus Gleophyllwn lraebeum, this molecule is thought to bind to Fe3+ in a hexacoordinate system to aid in transport through cell walls in order to help regulate iron levels in such iron-deficient fungi. Since the proposed structure of the molecule is based only on the spectral data of a very small sample, our hope is to synthesize and confirm its structure as the extract of the brown rot fungus. We have developed a relatively short retrosynthesis for our work on this …
Determination Of Nizatidine-Guest Complexation Constants And Computer Aided Molecular Design, Carolyn J. Mordas
Determination Of Nizatidine-Guest Complexation Constants And Computer Aided Molecular Design, Carolyn J. Mordas
Honors Theses
Nizatidine, N-[2-[[[2-[(dimethylamino)methyl]-4-thiazoly]]methy1]thio]ethyl]-N'- methyl- 2-nitro-I,l, ethenediamine, has been investigated for its potential to act as a host to small molecules through hydrogen bonding and pi-pi interactions. In previous work, pyridoxine (vitamin B6) was hypothesized to have a high guest-host binding constant with nizatidine. This was supported through experimental methods involving one and two dimensional NMR spectroscopy, UV-visible spectroscopy, and high performance liquid chromatography. Computer aided molecular design and three dimensional conformationally flexible database searching led to the discovery of other possible guests, including albuterol, which has exhibited even higher binding constants from HPLC.