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Articles 1 - 30 of 31
Full-Text Articles in Physical Sciences and Mathematics
Stress-Sensing In Flexible Epoxy Adhesives, Christine Rukeyser
Stress-Sensing In Flexible Epoxy Adhesives, Christine Rukeyser
Honors Theses
In mechanochemistry, mechanical force causes a chemical change using small molecules, called mechanophores, by covalently connecting them into polymer materials. Stress-sensing mechanophores give a visual signal of mechanical force on the molecular level within a material. To our knowledge, stress-sensing mechanophores have never been incorporated into a commercially available epoxy kit. In this work, the characterization of two 3MTM Scotch-Weld TM Epoxy Adhesive kits: DP100 Plus Clear and DP190 Translucent have been completed through FT-IR Spectroscopy. The addition of the mechanophore spiropyran to the 3M kits will be discussed; as well as preparation and characterization of three dimerized anthracene derivatives. …
Modeling Surface Structures For The Capture Of Carbon Dioxide, Paige Freyre
Modeling Surface Structures For The Capture Of Carbon Dioxide, Paige Freyre
Honors Theses
Our research utilized a modified graphene surface model to simulate capture of carbon dioxide and nitrogen gas based on van der Waals forces and hydrogen bonding. We completed an extensive review of the literature for model and experimental surfaces used to trap carbon dioxide and nitrogen gas into structures and pores with varying functional groups, pore sizes, and pore structures. We replicated the design of selected published models and compared their and our calculated binding energies. We used Scigress (Fujitsu) software with the Molecular Mechanics MM3 parameter set to perform calculations to analyze a proposed graphene surface pore lined with …
Synthesis And Characterization Of Organometallic Complexes For Biological Imaging, Emily Stumbo
Synthesis And Characterization Of Organometallic Complexes For Biological Imaging, Emily Stumbo
Honors Theses
Luminescent transition metal complexes are of interest for biological imaging applications due to their unique photophysical properties including large Stokes shift, long fluorescence lifetimes, and tunable emission. Altering ligand structure is a useful way to manipulate the charge transfer (CT) and mixed character states that give these complexes their photophysical properties. A series of organometallic complexes containing ligands with externally facing nitrogens has been prepared and synthesized. Complexes of the form Pt (II)(tbbpy)(C2-py), Re(CO)3(N^N), Ir(C^N)2(N^N), and Ir(C^N)2(N^O) have been studied for their potential application as biological imaging agents. The goal of this project is to compare the properties of these …
Theoretical Studies Of Benzoquinone Reactivity In Acidic And Basic Environments, Natali Majoras
Theoretical Studies Of Benzoquinone Reactivity In Acidic And Basic Environments, Natali Majoras
Honors Theses
Quinones are a class of organic compounds containing a six-membered unsaturated ring with two carbonyl groups. They are biologically relevant mostly due to their ability to participate in redox reactions. Prior experiments in our lab showed that quinones can induce protein modifications that are pH dependent. In an acidic environment the modifications were less significant than in a basic environment. Previous computational studies have also been carried out to model, in neutral solutions, the reaction between various quinones and various amines. Various amine groups are used as a model for the amino group of lysine to represent protein modification. The …
Molecular Dynamic Simulation Of The Complex Folding Patterns Of Apolipoprotein A1 In Various Concentrations Of Potassium Chloride, Hannah Holmberg
Molecular Dynamic Simulation Of The Complex Folding Patterns Of Apolipoprotein A1 In Various Concentrations Of Potassium Chloride, Hannah Holmberg
Honors Theses
Apopliprotein or ApoA-1 is a complex lipoprotein that functions in the removal of cholesterol from the blood, removing cholesterol from the area around white blood cells and promoting the excretion of lipids through the lymphatic system. Previous research has found that ApoA-1 shows both folded and unfolded conformations depending on the concentration of NaCl in solution in the water around it. The protein was studied using molecular dynamics simulations. Once this state of equilibrium was reached, various structural properties of the protein were measured including the radius of gyration and the radial distribution function. The goal of the project was …
Synthesis, Characterization, And Reactivity Of Organometallic Complexes For Catalytic Carbon-Hydrogen Bond Activation, Sophia Neglia
Synthesis, Characterization, And Reactivity Of Organometallic Complexes For Catalytic Carbon-Hydrogen Bond Activation, Sophia Neglia
Honors Theses
Styrene can be produced directly from benzene and ethylene through an atom economical oxidative hydroarylation process. In this process, an electrophilic homogeneous transition metal catalyst activates the C-H bond in benzene. I propose to explore this reaction in two fronts: 1) the synthesis of electron-poor trans-spanning bidentate pyridine ligands and 2) the computational study of pyridine-functionalized bidentate diimines. The trans-spanning ligand will utilize either a Ru(II) or Co(III) metallohinge with cis-coordinated 2-ethynylpyridine ligands. The complex [(p-cym)Ru(PMe3)(C2-2-py)2] (1) where (p-cym = para-cymene and C2-2-py = 2-ethynylpyridine) can be prepared from (p-cym)Ru(PMe3)(Cl)2 and HC2-2-py in the presence of lithium bis(trimethylsilyl)amide (LiHMDS). Complex …
Understanding Shear Thinning Using Brownian Dynamics Simulation, Mackenzie Nicole Wall
Understanding Shear Thinning Using Brownian Dynamics Simulation, Mackenzie Nicole Wall
Honors Theses
In this work, we study the changes in structure during the shear thinning regime using Brownian Dynamics with a simple steady-state shear flow of binary charged colloidal suspension. Previous research has analyzed the viscosity, radial distribution, elasticity and plasticity of materials with rheo-SANS experimentation; however, less research has been conducted to replicate the experiment through computer simulations. With Brownian Dynamic Simulation, this study was able to reproduce the results obtained in a recent rheo-SANS experiment and it also explored the viscosity, radial distribution, elastic and plastic behavior of a system under different parameters. The comparison of simulated data with experimental …
The Effect Of The Apolipoprotein A1 (Apoa1): The Stability And Folding In Potassium Chloride Environment, Alexandra Paladian
The Effect Of The Apolipoprotein A1 (Apoa1): The Stability And Folding In Potassium Chloride Environment, Alexandra Paladian
Honors Theses
Healthy levels of potassium chloride (KCl) can significantly affect the workings of the cholesterol level of the human body and how they pertain to an individual person. The search for a better salt additive for the human diet can provide a better option for people who experience high cholesterol levels and heart disease. The study focuses on the experimental design of the Molecular Dynamic (MD) simulation of the Apolipoprotein A1 (APOA1) in the potassium ion solution environment to determine the stability and folding of the protein. The study also compares its data to the previous experimental design of chloride ions …
Hplc Detection Of Organic Gunshot Residues With Silicone Wristbands, Yelyzaveta Zuy
Hplc Detection Of Organic Gunshot Residues With Silicone Wristbands, Yelyzaveta Zuy
Honors Theses
The analysis of gunshot residue (GSR) is frequently used to aid in investigating firearm-related crimes. Typically, Scanning Electron Microscopy (SEM) is applied for inorganic analysis of elements such as lead, barium, and antimony to study GSR. However, heavy metal-free ammunition creates the need for a different type of approach. This research focuses on studying the potential of detecting organic gunshot residue (OGSR) collected with silicone wristbands through passive sampling. This study has been directed towards the development of an optimal High Performance Liquid Chromatography (HPLC) procedure for the detection and separation of five selected compounds typically found in OGSR. The …
Molecular Dynamics Simulations Of Apolipoprotein A1 In Ionic Liquids, Benjamin Smith
Molecular Dynamics Simulations Of Apolipoprotein A1 In Ionic Liquids, Benjamin Smith
Honors Theses
High-density lipoprotein function is essential for the healthy processing of fats in the blood. The function of these proteins is determined by their conformational structure of chains of amino acids. Certain ionic liquids have been shown to interact with individual amino acids to affect the tertiary shape of the protein. These interactions can disrupt the native hydrogen bonds between amino acids which can either promote folding or denaturing of the protein. Our work focused on apoA-1, a high-density lipoprotein that binds to cholesterol for efflux from the body. We studied this protein in different ion-based liquids with sodium, chloride, and …
Theoretical Studies Of Naphthoquinone Reactivity Toward Amines, Kevin Lee
Theoretical Studies Of Naphthoquinone Reactivity Toward Amines, Kevin Lee
Honors Theses
Quinones are a class of organic compounds containing a six-membered unsaturated cyclic ring with two carbonyl groups and are biologically relevant due to their ability to participate in redox reactions. Experiments have showed that quinones can induce protein modifications including oligomerization and polymerization by binding to proteins. To complement these experimental studies, theoretical studies of naphthoquinone reactivity toward an amino group were conducted. The reactions between three naphthoquinones, 1,2-naphthoquinone (ONQ), 1,4-naphthoquinone (PNQ), and 2-hydroxy-1,4-naphthoquinone (HNQ), and methylamine, a N-containing nucleophile, were investigated. For each naphthoquinone, the first step of both 1,2- and 1,4-additions at all possible C=O positions were examined. …
Preparation Of Organometallic Cobalt(Iii) Complexes Containing Bidentate Chiral Amine Ligands As Potential Transfer Hydrogenation Catalysts, Luccas C. Do Carmo
Preparation Of Organometallic Cobalt(Iii) Complexes Containing Bidentate Chiral Amine Ligands As Potential Transfer Hydrogenation Catalysts, Luccas C. Do Carmo
Honors Theses
Mixed coordination sphere cobalt(III) complexes containing a chiral bidentate amine ligand and an organic carbocyclic ligand have been prepared and characterized. The integration of this mixed ligand environment involving an organometallic and Werner-type ligand along with the earth abundant metal in a high oxidation state has the potential for interesting reactivity. Complexes of the type [Co(CpR)(X-DPEN)(I)](I), where CpR = cyclopentadienyl (Cp, R = H) or pentamethylcyclopentadienyl (Cp*, R = Me) and X = meso-1,2-, 1R,2R-, and 1S,2S-, have been prepared by ligand substitution from [Co(CpR)(I)2(CO)] with 1,2-diphenyletheylenediamine (DPEN). The outer sphere iodide is readily exchangeable with sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (NaBArF) or …
Active Colloid Behavior Exhibiting Soft-Sphere Characteristics For Non-Newtonian Solvent, Courtney Baier
Active Colloid Behavior Exhibiting Soft-Sphere Characteristics For Non-Newtonian Solvent, Courtney Baier
Honors Theses
The purpose of analyzing soft-sphere Brownian particles with varying velocities and densities is to be able to predict their interaction behavior once a force has been applied. The particles portray different behaviors depending on if the particles are passive or active Brownian particles. The data studied was collected from simulations, and there are no attractive forces involved in the particles’ interactions. Mean square displacement graphs, radial distribution graphs, structure factor graphs, and viscosity as a function of density and velocity were used to examine and compare the data generated. Experimental data was analyzed by a program to be interpreted into …
Cigarette Litter Leachates: A Statistical Study Of Elements In Freshwater And Saltwater, Cintly Guzman Hernandez
Cigarette Litter Leachates: A Statistical Study Of Elements In Freshwater And Saltwater, Cintly Guzman Hernandez
Honors Theses
Cigarette butts are the most common item found in coastal litter cleanups as approximately 4.5 trillion smoked cigarette butts are discarded into the environment every year. Cigarette butts can leach toxic heavy metals and nicotine along with other compounds from tobacco combustion. Past research in our lab has analyzed elements leached from cigarette butts into freshwater. The cigarette butts consisted of smoked and unsmoked butts that were soaked varying periods of time, and at different pH levels to identify the relationship of these variables to the amount of metal leached. The elements analyzed were Al, Ba, Cd, Cr, Cu, Fe, …
Phospholipid Membrane Remodeling Through Exogenous Fatty Acid Incorporation In Certain Bacterial Species, Josh Herndon
Phospholipid Membrane Remodeling Through Exogenous Fatty Acid Incorporation In Certain Bacterial Species, Josh Herndon
Honors Theses
Multi-drug resistant bacteria have become problematic in healthcare settings. Recent studies have documented the ability of some bacteria, such as Vibrio species, to assimilate exogenous fatty acids into their membrane phospholipids. Therefore, the current research was performed to determine whether the three virulent, multi-drug resistant bacteria Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli can remodel their cell membranes following exposure to a range of exogenous polyunsaturated fatty acids (PUFAs). Furthermore, we hypothesized that PUFAs would influence phenotypes associated with growth and virulence. Extracted phospholipids were examined by UPLC/MS analysis to confirm assimilation of exogenous PUFAs into the bacterial phospholipids. A. …
Sds-Page Analysis Of Modified Lysozyme By Substituted Benzoquinones And Naphthoquinones, Neethu Kurien
Sds-Page Analysis Of Modified Lysozyme By Substituted Benzoquinones And Naphthoquinones, Neethu Kurien
Honors Theses
Quinones are molecules that are commonly found in the environment, as cofactors for proteins or an electron carrier in the mitochondrial electron transport chain. However, quinones also can come from polycyclic aromatic hydrocarbons as their metabolites, harming cellular integrity. In this study, we investigated protein modification of lysozyme in the presence of substituted benzoquinones and naphthoquinones. To simulate physiological conditions, all reactions used phosphate buffer (50.0 mM). While the majority of the experiments were performed at 37 C and pH 7.0, there were also temperature dependence (27 C and 42 C) and pH dependence (6.0 and 8.0) reactions included. SDS-PAGE …
Developmental Steroids And Vitamins: Identified And Quantified In Predatory Lady Beetles, Andrea Hixson
Developmental Steroids And Vitamins: Identified And Quantified In Predatory Lady Beetles, Andrea Hixson
Honors Theses
Autumn brings ladybeetles into homes to seek shelter during the winter, which is a nuisance. Their bites may induce an allergic reaction resulting in painful rashes. Predatory ladybeetles have been used as a biological control agents. Not only do they feed on ecological pests, they also feed on the saps of ripe fruits reducing the value of the damaged crop. Two species of ladybeetles (Coleoptera: Coccinellidae) will be examined to determine the quantities of steroids and vitamins used throughout their life stages. The species examined are native, Hippodamia convergens, of North America, and an invasive, Harmonia axyridis, of Asia. The …
Octahedral Ruthenium(Ii) Complexes For C-H Bond Activation And Olefin Hydroarylation, Patrick Z. Zdunek
Octahedral Ruthenium(Ii) Complexes For C-H Bond Activation And Olefin Hydroarylation, Patrick Z. Zdunek
Honors Theses
The study of inert C-H bond activation of hydrocarbons has been gaining interest. As these hydrocarbons are used in the production of many consumables such as fuel, plastics, and detergents, it is necessary to efficiently utilize the finite quantity of petroleum feedstocks. Transition metal complexes are incorporated as catalysts into synthetic routes to create new C-X (X = C, N, O) bonds in order to increase the chemical value of organic molecules. The complex [Ru(η6-p-cymene){P(OCH2CF3)3}(Ph)(OTf)] (1) (P{OCH2CF3}3 = tris(2,2,2-trifluoroethyl) phosphite, Ph = phenyl, OTf = trifluoromethanesulfonate) was prepared and tested for functionality as a catalyst in olefin hydroarylation. Catalytic reactions …
Fluorescence And Uv-Vis Studies Of Quinone-Induced Protein Modifications, Charles A. Thomas Jr
Fluorescence And Uv-Vis Studies Of Quinone-Induced Protein Modifications, Charles A. Thomas Jr
Honors Theses
Quinones are the metabolites of a class of chemicals known as polycyclic aromatic hydrocarbons. These chemicals have been found to be toxic in the environment, especially when interacting with certain proteins. In this study, we investigated the modification of Lysozyme and Ribonuclease A by a series of benzoquinones as well as few naphthoquinones. Fluorescence spectroscopy was used to measure the degree of modification of Lysozyme and Ribonuclease A when incubated with quinones at differing concentrations and for various times. All reactions, unless noted, were carried out in a phosphate buffer (pH=7.0) at 37°C to mimic physiological conditions. The fluorescence intensity …
A Study Of The Photoacoustic Effect In Ethylene Gas, Jay Nguyen
A Study Of The Photoacoustic Effect In Ethylene Gas, Jay Nguyen
Honors Theses
Ethylene, C2H4, is a plant hormone produced and released naturally by plants and soil microorganisms. This colorless, flammable gas has a slightly sweet odor usually only recognized by those who have handled ethylene before. In situ analyses of this gas and many other potentially harmful gases outside of the laboratory are often difficult to perform due to the lack of a portable yet reliable unit capable of precisely and accurately detecting and measuring the concentrations of these gases at trace gas concentrations of a few parts per billion. In this research project, photoacoustic spectroscopy was used to detect and measure …
Assessing The Feasibility Of A One-Pot, Tandem Olefin Metathesis And Isomerization Sequence To Synthesize Conjugated Aromatic Olefins, Ajay D. Makwana
Assessing The Feasibility Of A One-Pot, Tandem Olefin Metathesis And Isomerization Sequence To Synthesize Conjugated Aromatic Olefins, Ajay D. Makwana
Honors Theses
The synthesis of substituted phenylpropene dimers using a one-pot, tandem olefin metathesis and isomerization sequence has been studied. This sequence relies on the facilitated, in-situ conversion of a ruthenium carbene species (Ru=C) to a ruthenium hydride species (Ru-H) upon addition of an inorganic hydride source. Three separate reactions occur within one reaction flask: 1) olefin metathesis of the starting phenylpropene to yield phenylpropene dimer via Ru=C catalyst, 2) conversion of Ru=C to Ru-H via addition of an inorganic hydride source, 3) isomerization of phenylpropene dimer via insertion and β-hydride elimination to yield conjugated product. The focus of the study has …
Effects Of Cigarette Butts On Coastal Waters: An Elemental Analysis Of Seawater From St. Simon’S Island, Katherine Adorati
Effects Of Cigarette Butts On Coastal Waters: An Elemental Analysis Of Seawater From St. Simon’S Island, Katherine Adorati
Honors Theses
Cigarette litter can have detrimental effects on the environment, specifically when taking into account that over 4.5 trillion cigarette butts are littered every year. Within seawater, trace elements present in cigarettes may leach into the ocean, having damaging effects on the marine ecosystem. The goal of this research was to investigate if elemental contaminants leached from cigarette litter are significant in samples of seawater collected near St. Simon’s Island at both high and low tides, surrounding a beach party during the Florida/Georgia football game which occurred on November 1, 2014. Samples were collected in the months prior to and during …
Exogenous Polyunsaturated Fatty Acid (Pufa) Scavenging Affects Phospholipid Profiles And Virulence Phenotypes In Vibrio Cholerae And Vibrio Parahaemolyticus, Anna Moravec
Honors Theses
AIM: This research had two primary objectives. First, this study sought to determine whether or not exposing Vibrio cholerae and Vibrio parahaemolyticus to polyunsaturated fatty acids (PUFAs) would lead to changes in their respective phospholipid profiles. Secondly, if membrane remodeling occurred, this study sought to determine the impact of membrane modifications on bacterial fitness by evaluating their effect on membrane permeability, biofilm formation, and response to stresses. METHODS: The Bligh and Dyer method was used to extract bacterial lipids, which were subsequently analyzed via thin-layer chromatography (TLC). The effect of fatty acids on bacterial fitness was assessed using stress, biofilm, …
Analysis Of An Electrospun Nanofiber Device Applicable To Limb Salvage: Mass Loss, Morphological Changes, And Quantification Of Antibiotic Release, Caitlin Quinn
Honors Theses
The creation of an electrospun nanofiber embedded with two antibiotics that will be used to prevent infection while also stimulating bone regeneration will be explored. The nanofiber will contain an aminoglycoside and a glycopeptide, and it is sought to deliver a sustained release of antibiotics for up to 12 weeks. To determine release rate, nanofiber samples are immersed in 10.0 mL of MiliQ water (MQ), incubated at 37°C, assayed at specific time intervals, and then analyzed using ultra performance liquid chromatography in tandem with mass spectrometry. A hydrophilic interaction liquid chromatography (HILIC) method utilizing ultra-performance liquid chromatography (UPLC) in tandem …
Modifications Of Lysozyme By Substituted Benzoquinones, Hendrik J. Greve
Modifications Of Lysozyme By Substituted Benzoquinones, Hendrik J. Greve
Honors Theses
Amyloidosis, which involves the precipitation of mis-folded protein aggregates, is a prominent process that occurs in many neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease; the protein aggregates being amyloid-β for Alzheimer’s disease and α-synuclein for Parkinson’s disease. This study has focused on lysozyme modifications induced by metabolites of the commonly found pollutants known as polycyclic aromatic hydrocarbons (PAHs). PAHs are found in substances ranging from grilled meats to cigarette smoke to cosmetics, and they can be metabolized into a family of biological toxins known as benzoquinones. The molecules of interest for this study were 1,4-benzoquinone (pBQ), 2-chloro-1,4-benzoquinone (CBQ), …
Determination Of Antibiotic Release From Electrospun Nanofibers, John P. O'Brien Iii
Determination Of Antibiotic Release From Electrospun Nanofibers, John P. O'Brien Iii
Honors Theses
Decreasing the risk of infection following surgery for traumatic bone breaks is a major focus of the medical and scientific community. Drug delivery devices are emerging as powerful solutions for combating infection following these procedures. Current devices, however, suffer several drawbacks including poor antibiotic release rate and control the devices themselves not being biodegradable. This thesis studies the \textit{in vitro} release rate for antibiotics tobramycin and vancomycin from a biodegradable medical implant. Antibiotics, collagen, and bone growth factors are incorporated into Poly(lactide-co-glycolide)-based electrospun nanofibers by local company eSpin for development. The drug-loaded nanofibers are immersed in phosphate buffered saline (PBS) …
Synthesis Of Novel Dienes And Cyclic Compounds Via Olefin Metathesis Reactions Catalyzed By The Second Generation Grubbs Catalyst, Patrick Joseph Carey
Synthesis Of Novel Dienes And Cyclic Compounds Via Olefin Metathesis Reactions Catalyzed By The Second Generation Grubbs Catalyst, Patrick Joseph Carey
Honors Theses
Transition metal-catalyzed olefin metathesis reactions play a significant role in chemical synthesis. These reactions are currently applied across several disciplines, and their full potential has not yet been reached. This project details the synthesis of spiro[3-cyclopentene-1,9’-[9H]fluorene], 1-(1-amino-2-methylpropyl)-3-cyclopentenol, and the eugenol dimer via olefin metathesis reactions catalyzed by the second generation Grubbs catalyst. The unique structural properties of each compound help demonstrate the widespread abilities of these reactions. Also reported are the novel three-dimensional crystal structures of both spiro[3-cyclopentene-1,9’-[9H]fluorene] and the eugenol dimer. These structures were determined via X-ray diffraction crystallography methods using a Bruker SMART X2S Single Crystal Diffractometer. Both …
Ribonuclease A Modification Induced By 1,2-Naphthoquinone And 2-Hydroxy-1,4-Naphthoquinone, Michelle Dawn Smith
Ribonuclease A Modification Induced By 1,2-Naphthoquinone And 2-Hydroxy-1,4-Naphthoquinone, Michelle Dawn Smith
Honors Theses
Protein modifications may occur upon exposure to environmental toxins such as polycyclic aromatic hydrocarbon (PAH) molecules or their metabolites. In this context, our laboratory was interested in investigating protein modifications in the presence of select naphthoquinones, which were 2-hydroxy-1,4-naphthoquinone (HNQ) and 1,2-naphthoquinone (o-NQ). The effects of HNQ and o-NQ on the protein Ribonuclease A (RNase) were investigated through a variety of conditions. These modified incubation conditions included pH variation and the addition of metal ions to further mimic physiological conditions. Documentation of results was carried out through sodium dodecyl sulfate polyacrylamide gel electrophoretic analysis (SDS-PAGE). Of the two quinones, o-NQ …
Reduction Of Ketoximes To Amines By Catalytic Transfer Hydrogenation Using Raney Nickel And 2-Propanol As Hydrogen Donor, Katherynne E. Taylor
Reduction Of Ketoximes To Amines By Catalytic Transfer Hydrogenation Using Raney Nickel And 2-Propanol As Hydrogen Donor, Katherynne E. Taylor
Honors Theses
Ketoximes successfully underwent hydrogenolysis and hydrogenation under catalytic transfer conditions with Raney Nickel and 2-propanol as a hydrogen donor. Ketoximes were reduced to primary amines when 2% KOH was included in the reaction. In the absence of KOH N-isopropyl-secondary-amines were obtained in good yields.
Nicotine And What Else?: Hplc Elution Optimization For The Analysis Of Alkaloids Found In Electronic Cigarettes, Jessica L. Murray
Nicotine And What Else?: Hplc Elution Optimization For The Analysis Of Alkaloids Found In Electronic Cigarettes, Jessica L. Murray
Honors Theses
Electronic cigarettes, or e-cigarettes, have been scrutinized by the Food and Drug Administration and other public health organizations for issues related to quality control and efficacy. Erratic nicotine delivery and numerous toxic compounds in refill solutions have been reported. The ultimate goal of this research is to add to the growing amount of knowledge regarding e-cigarette ingredient content, safety, and quality. Standards of the tobacco alkaloids nicotine, anabasine, cotinine, and myosmine were prepared and quantified using high performance liquid chromatography (HPLC). Various elution schemes were tested and adjusted for optimal analyte resolution, and a final elution scheme was developed to …