Physical Sciences and Mathematics Commons^™

Construction Of Trisubstituted Chromone Skeletons Carrying Electron-Withdrawing Groups Via Phio-Mediated Dehydrogenation And Its Application To The Synthesis Of Frutinone A, Qiao Li, Chen Zhuang, Donghua Wang, Wei Zhang, Rongxuan Jia, Fengxia Sun, Yilin Zhang, Yunfei Du

Faculty & Staff Scholarship

Abstract

The construction of the biologically interesting chromone skeleton was realized by PhIO-mediated dehydrogenation of chromanones under mild conditions. Interestingly, this method also found application in the synthesis of the naturally occurring frutinone A.

Effect Of Bulk Composition On The Heterogeneous Oxidation Of Semi-Solid Atmospheric Aerosols, Hanyu Fan, Fabien Goulay

Faculty & Staff Scholarship

Abstract: The OH-initiated heterogeneous oxidation of semi-solid saccharide particles with varying bulk compositions was investigated in an atmospheric pressure flow tube at 30% relative humidity. Reactive uptake coefficients were determined from the rate loss of the saccharide reactants measured by mass spectrometry at different monosaccharide (methyl-β-d-glucopyranoside, C7H14O6) and disaccharide (lactose, C12H22O11) molar ratios. The reactive uptake for the monosaccharide was found to decrease from 0.53 ± 0.10 to 0.05 ± 0.06 as the mono-to-disaccharide molar ratio changed from 8:1 to 1:1. A reaction–diffusion model was developed in order to determine the effect of chemical composition on the reactive uptake. The …

Construction Of A Cross-Layer Linked G-Octamer Via Conformational Control: A Stable G-Quadruplex In H-Bond Competitive Solvents, Ying He, Yanbin Zhang, Luksaz Wojtas, Novruz G. Akhmedov, David Thai, Heng Wang, Xiaopeng Li, Hao Guo, Xiaodong Shi

Faculty & Staff Scholarship

Methanol soluble and stable guanosine octamers were successfully achieved via H-bond self-assembly. Through structural conformational design, we developed a new class of guanosine derivatives with modification on guanine (8-aryl) and ribose (20 ,30 -isopropylidene). This unique design led to the formation of the first discrete G8-octamer with its structure characterized by single crystal X-ray diffraction, MS and NMR spectroscopy. The G8-octamer showed unique cation recognition properties, including the formation of a stable Rb+ templated G-quadruplex. Based on this observation, further modification on the 8-aryl moiety was performed to incorporate a cross-layer H-bond or covalent linkage. Similar G-octamers were obtained in …