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Full-Text Articles in Physical Sciences and Mathematics
Forensic Applications Of Capillary Electrophoresis, Jennifer A. Jakubowski
Forensic Applications Of Capillary Electrophoresis, Jennifer A. Jakubowski
Honors Theses
The separation by capillary zone electrophoresis (CZE) of the chiral narcotic propoxyphene is the goal of this work. A three-way collaboration between our research group, Professor lsiah Warner (LSU), and the New York State Forensic Investigation Center is underway, with the goal of separating controlled substances and developing techniques that the Forensic Center can apply in it& investigations. Earlier studies by Warner's group have shown that using polymerized N-undecylenyl-L-amino acid and peptide derivatives as pseudo-stationary phases in CZE has resulted in the separation of chiral molecules. Our separations were attempted by combining the drug samples with polymerized N-undecylenyl-L-amino acid and …
Stereoselection In The Preparation Of Alpha-Oxy-Beta-Amino Esters : Revealing The Mechanism, Richard James Fox
Stereoselection In The Preparation Of Alpha-Oxy-Beta-Amino Esters : Revealing The Mechanism, Richard James Fox
Honors Theses
Due to their significant pharmaceutical applications, the development of efficient, stereoselective synthetic routes for the preparation of α-substituted-β-amino esters has become increasingly important. We demonstrated that the titanium enolates (47) of a.alkoxy acetate esters (48) add cleanly to imines (49), and predominately afford the anti diastereomer of the a.-oxy-f3-amino ester product (50). Furthermore, by altering the electronic properties of the ether oxygen, sterics of the ester and temperature conditions, we changed the anti:syn product ratio. We rationalized the origin of these effects, and proposed a mechanism of imine addition.
Diastereoselection In Titanium Enolate Addition To Aldmines, Julia Leigh Barkin
Diastereoselection In Titanium Enolate Addition To Aldmines, Julia Leigh Barkin
Honors Theses
A mild and versatile synthesis of a-oxy-6-amino esters has been performed by condensation of the chlorotitanium enolates of methyl methoxyacetate with aldimines. The imine-aldol addition occurs in excellent yields without Lewis acid activation of the imine. All aryl imines examined show good to excellent diastereoselection for the anti isomers.
Fluorescence Studies Of Tris (2,2'-Bipyridine) Ruthenium (Ii) In Thin Clay Films, Samuel James Salamone
Fluorescence Studies Of Tris (2,2'-Bipyridine) Ruthenium (Ii) In Thin Clay Films, Samuel James Salamone
Honors Theses
Because of their rich intercalation chemistry and ability to enhance the thermal stability of the included guest, layered silicate clays are excellent hosts for the fabrication of organic/inorganic nanocomposites. Composites of hectorite and tris(2, 2' -bipyridine) ruthenium(U), Ru(bpy), 3 2+, have attracted attention owing to their potential applications as glucose and oxygen based chemical sensors. Previous studies on the fluorescence behavior of Ru(bpy)3 2+ complexes in aqueous colloidal clay suspensions have shown enhanced emission traces. We report here the first study of the fluorescence responses of Ru(bpy) 3 2+ exchanged thin clay films. Variation of guest concentration and exposure time …