Physical Sciences and Mathematics Commons^™

Ratiometric Single-Nanoparticle Oxygen Sensors For Biological Imaging, Changfeng Wu, Barbara Bull, Kenneth Christensen, Jason Mcneill

Publications

It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.