Physical Sciences and Mathematics Commons^™

Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost

All Dissertations

In confocal single-molecule FRET experiments, the joint distribution of FRET efficiency and donor lifetime distribution can reveal underlying molecular conformational dynamics via deviation from their theoretical Forster relationship. This shift is referred to as a dynamic shift. In this study, we investigate the influence of the free energy landscape in protein conformational dynamics on the dynamic shift by simulation of the associated continuum reaction coordinate Langevin dynamics, yielding a deeper understanding of the dynamic and structural information in the joint FRET efficiency and donor lifetime distribution. We develop novel Langevin models for the dye linker dynamics, including rotational dynamics, based …

Concentration Theorems For Orthonormal Sequences In A Reproducing Kernel Hilbert Space, Travis Alvarez

All Dissertations

Let H be a reproducing kernel Hilbert space with reproducing kernel elements {Kx} indexed by a measure space {X,mu}. If H can be embedded in L2(X,mu), then H can be viewed as a framed Hilbert space. We study concentration of orthonormal sequences in such reproducing kernel Hilbert spaces.

Defining different versions of concentration, we find quantitative upper bounds on the number of orthonormal functions that can be classified by such concentrations. Examples are shown to prove sharpness of the bounds. In the cases that we can add "concentrated" orthonormal vectors indefinitely, the growth rate of doing so is shown.

Asymptotic Cones Of Quadratically Defined Sets And Their Applications To Qcqps, Alexander Joyce

All Dissertations

Quadratically constrained quadratic programs (QCQPs) are a set of optimization problems defined by a quadratic objective function and quadratic constraints. QCQPs cover a diverse set of problems, but the nonconvexity and unboundedness of quadratic constraints lead to difficulties in globally solving a QCQP. This thesis covers properties of unbounded quadratic constraints via a description of the asymptotic cone of a set defined by a single quadratic constraint. A description of the asymptotic cone is provided, including properties such as retractiveness and horizon directions.

Using the characterization of the asymptotic cone, we generalize existing results for bounded quadratically defined regions with …

Recovering Coefficients Of Second-Order Hyperbolic And Plate Equations Via Finite Measurements On The Boundary, Scott Randall Scruggs

All Dissertations

Abstract In this dissertation, we consider the inverse problem for a second-order hyperbolic equation of recovering n + 3 unknown coefficients defined on an open bounded domain with a smooth enough boundary. We also consider the inverse problem of recovering an unknown coefficient on the Euler- Bernoulli plate equation on a lower-order term again defined on an open bounded domain with a smooth enough boundary. For the second-order hyperbolic equation, we show that we can uniquely and (Lipschitz) stably recover all these coefficients from only using half of the corresponding boundary measurements of their solutions, and for the plate equation, …