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Full-Text Articles in Translational Medical Research
Lipin Expression Is Attenuated In Adipose Tissue Of Insulin-Resistant Human Subjects And Increases With Peroxisome Proliferator-Activated Receptor Γ Activation, Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Lesliie M. Miles, Bounleut Phanavanh, Tasha Starks, Jack Phan, Horace J. Spencer Iii, Robert E. Mcgehee Jr., Karen Reue, Philip A. Kern
Lipin Expression Is Attenuated In Adipose Tissue Of Insulin-Resistant Human Subjects And Increases With Peroxisome Proliferator-Activated Receptor Γ Activation, Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Lesliie M. Miles, Bounleut Phanavanh, Tasha Starks, Jack Phan, Horace J. Spencer Iii, Robert E. Mcgehee Jr., Karen Reue, Philip A. Kern
Clinical and Translational Science Faculty Publications
Lipin-α and -β are the alternatively spliced gene products of the Lpin1 gene, whose product lipin is required for adipocyte differentiation. Lipin deficiency causes lipodystrophy, fatty liver, and insulin resistance in mice, whereas adipose tissue lipin overexpression results in increased adiposity but improved insulin sensitivity. To assess lipin expression and its relation to insulin resistance in humans, we examined lipin-α and -β mRNA levels in subjects with normal or impaired glucose tolerance. We found higher expression levels of both lipin isoforms in lean, insulin-sensitive subjects. When compared with normal glucose-tolerant subjects, individuals with impaired glucose tolerance were more insulin resistant, …
Pioglitazone Induces Apoptosis Of Macrophages In Human Adipose Tissue, Angela M. Bodles, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Bounleut Phanavanh, Charlotte A. Peterson, Robert E. Mcgehee Jr., Neda Rasouli, Martin Wabitsch, Philip A. Kern
Pioglitazone Induces Apoptosis Of Macrophages In Human Adipose Tissue, Angela M. Bodles, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Bounleut Phanavanh, Charlotte A. Peterson, Robert E. Mcgehee Jr., Neda Rasouli, Martin Wabitsch, Philip A. Kern
Clinical and Translational Science Faculty Publications
Metabolic syndrome and type 2 diabetes mellitus are associated with an increased number of macrophage cells that infiltrate white adipose tissue (WAT). Previously, we demonstrated that the treatment of subjects with impaired glucose tolerance (IGT) with the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone resulted in a decrease in macrophage number in adipose tissue. Here, adipose tissue samples from IGT subjects treated with pioglitazone were examined for apoptosis with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining. TUNEL-positive cells were identified, and there was a significant 42% increase in TUNEL-positive cells following pioglitazone treatment. Overlay experiments with anti-CD68 antibody …