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Full-Text Articles in Translational Medical Research
Investigating The Mechanisms Of Breast Cancer Metastasis Using Multimodality Molecular Imaging, Katie Parkins
Investigating The Mechanisms Of Breast Cancer Metastasis Using Multimodality Molecular Imaging, Katie Parkins
Electronic Thesis and Dissertation Repository
Introduction: Breast cancer recurrence continues to be a significant challenge in the clinic. Despite successful removal and/or treatment of the original tumour, many patients experience relapse in the breast or at distant sites. Furthermore, the diagnosis of metastatic disease often occurs too late for effective treatment. Methods: In this thesis, we combine iron-based cellular MRI and longitudinal BLI to noninvasively track the fate of cancer cells into overt tumours in the mouse brain. We then apply this imaging model to study the effect of a primary breast tumour on the growth of secondary metastases in an immune competent …
Intraoperative Photoacoustic Imaging Of Breast Cancer, Ivan Kosik
Intraoperative Photoacoustic Imaging Of Breast Cancer, Ivan Kosik
Electronic Thesis and Dissertation Repository
Breast cancer is one of the most common cancers to affect women, presenting a lifetime risk of 1 in 8. Treatment of stage 1 and 2 cancers usually involves breast conserving surgery (BCS). The goal of BCS is to remove the entire tumour with a surrounding envelope of healthy tissue, referred to as a negative margin. Unfortunately, up to 50% of surgeries fail to remove the whole tumour. To minimize the risk of cancer recurrence, a second surgery, must therefore be performed. Currently, there is no widely accepted intraoperative tool to significantly mitigate this problem. Employed systems are usually based …