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Translational Medical Research Commons™
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- Pharmacokinetics (2)
- Alternative splicing (1)
- Angiogenesis (1)
- Apixaban (1)
- Crohn's disease (1)
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- Cytochrome P450 3A4 (1)
- Drug metabolism (1)
- Ductal carcinoma in situ (DCIS) (1)
- Electrical stimulation (1)
- Epithelial-mesenchymal transition (EMT) (1)
- Exome sequencing (1)
- Factor Xa inhibitor (1)
- Farnesoid X receptor (1)
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- Rivaroxaban (1)
- Single nucleotide variants (1)
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Articles 1 - 4 of 4
Full-Text Articles in Translational Medical Research
The Role Of Tbx3 In Early Breast Cancer Progression, Milica Krstic
The Role Of Tbx3 In Early Breast Cancer Progression, Milica Krstic
Electronic Thesis and Dissertation Repository
TBX3 is a transcriptional regulator involved in embryonic development and in tumorigenesis of several cancer types. There are two isoforms of TBX3 (TBX3iso1 and TBX3iso2) with different DNA binding domains. The large-scale functional roles of TBX3iso1 and TBX3iso2 were characterized in a breast cancer context. Both TBX3 isoforms induced invasiveness and an epithelial-to-mesenchymal (EMT) phenotype. Coupling data from genome-wide ChIP-array and RNA-Seq studies provided a novel list of genes regulated by each isoform. Both TBX3 isoforms regulate expression of several EMT-related genes, including SLUG and TWIST1. Importantly, TBX3 is a direct regulator of SLUG, and SLUG expression is required for …
Drug Response And Metabolism In Crohn's Disease, Aze Wilson
Drug Response And Metabolism In Crohn's Disease, Aze Wilson
Electronic Thesis and Dissertation Repository
Inflammatory bowel disease (IBD) is an illness of chronic intestinal inflammation comprised of Crohn's disease (CD) and ulcerative colitis (UC). Specialists rely heavily on drugs that target a dysregulated immune system. There is a staggering degree of variation in drug response in CD. Our understanding of drug metabolism and response in IBD is limited. Gaining new insights into IBD-specific modifications of drug metabolism may allow for improved drug efficacy and reduced toxicity. Cytochrome P450 (CYP) 3A4 is the most relevant determinant of drug metabolism and exposure for medications prescribed today. CYP3A4 is highly expressed in the liver, but is also …
From Evidence To Practice: A Systematic Approach To Implementing Electrical Stimulation Therapy For Treating Pressure Injuries In Community Dwelling Individuals With Spinal Cord Injury, Deena Lala
Electronic Thesis and Dissertation Repository
Pressure injuries are a common secondary health complication among individuals with a spinal cord injury (SCI) and can have a profound effect on quality of life. Unfortunately, pressure injury care in community dwelling individuals with SCI is often fragmented and inconsistent across Canada. Current best practice guidelines strongly recommend the use of electrical stimulation therapy (EST) to manage pressure injury in this population; however, there is little uptake of EST, and is not considered as a first-line treatment by many clinicians. Therefore, the objective of this dissertation is two-folds 1) to determine the impact of pressure injuries on individuals with …
Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat
Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat
Electronic Thesis and Dissertation Repository
Inhibition of blood coagulation via oral anticoagulant therapy is the mainstay for preventing a cardioembolic stroke in patients with atrial fibrillation (AF). Factor Xa inhibitors (FXaIs), rivaroxaban and apixaban, represent a new class of oral anticoagulants that are now widely prescribed in AF patients as an alternative to traditional warfarin therapy. An important advantage of these drugs is that routine monitoring of anticoagulation response is not necessary. Nevertheless, because of their mechanism of action, FXaI antithrombotic effect can be inferred based on the observed drug plasma concentration, with prolonged periods of elevated FXaI systemic exposure associated with increased risk for …