Translational Medical Research Commons^™

Daily Hydrogen Sulfide Treatment Enables Early Recovery Of Renal Function And Mitigates Renal Injury Following The Relief Of Prolonged Urinary Obstruction, Shouzhe Lin

Electronic Thesis and Dissertation Repository

Prolonged urinary obstruction can lead to renal dysfunction and irreversible injury. The recovery of renal function following decompression is heavily dependent on the degree of renal injury. This suggests that treatments aimed at mitigating renal injury could improve the recovery of renal function following decompression. Previous studies have shown that hydrogen sulfide (H₂S), an endogenous gasotransmitter, can reduce the histopathological markers of renal injury following unilateral ureteral obstruction (UUO). However, the effects of H₂S on renal function following decompression is unknown. Using the UUO and reimplantation (UUO-R) model, we demonstrate that H₂S accelerates the …